公开(公告)号：WO2002098300A3

公开(公告)日：2002-12-12

申请号：PCT/US2002/017503

申请日：2002-06-04

Applicant: ORATEC INTERVENTIONS, INC. ,  SHARKEY, Hugh, R. ,  UCHIDA, Andy ,  TO, Kevin ,  ASHLEY, John, E. ,  LE, Le, T.

Inventor： SHARKEY, Hugh, R. ,  UCHIDA, Andy ,  TO, Kevin ,  ASHLEY, John, E. ,  LE, Le, T.

IPC: A61B17/00

Abstract: An intervertebral disc device is provided comprising a probe capable of being extended from a distal end of an introducer that is percutaneously delivered into an interior of an intervertebral disc, the probe forming a loop when extended from the distal end of the introducer, the loop having first and second proximal ends external to the introducer which are brought together adjacent the introducer distal end to form the loop by the proximal ends being either attached to or entering the distal end of the introducer; and a proximal handle for externally causing the probe to be extended from the distal end of the introducer and externally guiding the probe within an intervertebral disc.

公开(公告)号：WO2002098300A2

公开(公告)日：2002-12-12

申请号：PCT/US2002/017503

申请日：2002-06-04

Applicant: ORATEC INTERVENTIONS, INC. ,  SHARKEY, Hugh, R. ,  UCHIDA, Andy ,  TO, Kevin ,  ASHLEY, John, E. ,  LE, Le, T.

Inventor： SHARKEY, Hugh, R. ,  UCHIDA, Andy ,  TO, Kevin ,  ASHLEY, John, E. ,  LE, Le, T.

IPC: A61B17/00

CPC classification number: A61B18/1492 ,  A61B2017/00261 ,  A61B2017/003 ,  A61B2018/0044 ,  A61B2018/1407

Abstract: An intervertebral disc device is provided comprising a probe capable of being extended from a distal end of an introducer that is percutaneously delivered into an interior of an intervertebral disc, the probe forming a loop when extended from the distal end of the introducer, the loop having first and second proximal ends external to the introducer which are brought together adjacent the introducer distal end to form the loop by the proximal ends being either attached to or entering the distal end of the introducer; and a proximal handle for externally causing the probe to be extended from the distal end of the introducer and externally guiding the probe within an intervertebral disc.

Abstract translation: 提供了一种椎间盘装置，其包括能够从经皮输送到椎间盘的内部的导引器的远端延伸的探针，所述探针在从所述导引器的远端延伸时形成环，所述环具有 引导器外部的第一和第二近端在导引器远端附近被组合在一起，以通过近端连接到引导器的远端或者进入导引器的远端; 以及用于外部使探针从导引器的远端延伸并且将探针外部引导到椎间盘内的近侧手柄。

公开(公告)号：WO2012100091A3

公开(公告)日：2012-11-08

申请号：PCT/US2012021920

申请日：2012-01-19

Applicant: ACCESSCLOSURE INC ,  UCHIDA ANDY H ,  SPIZUOCO ANTHONY P ,  TO KEVIN ,  LIM FLORENCIA ,  SERSHEN SCOTT R

Inventor： UCHIDA ANDY H ,  SPIZUOCO ANTHONY P ,  TO KEVIN ,  LIM FLORENCIA ,  SERSHEN SCOTT R

IPC: A61B17/00 ,  A61B17/12

CPC classification number: A61B17/0057 ,  A61B90/90 ,  A61B2017/00495 ,  A61B2017/00526 ,  A61B2017/00561 ,  A61B2017/0065 ,  A61B2017/00871 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00951 ,  A61B2017/22067 ,  A61B2017/22069 ,  A61L24/02 ,  C08L71/02

Abstract: A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.

Abstract translation: 提供用于密封穿刺组织的密封剂，所述密封剂包括细长的第一部分和第二部分，所述细长的第一部分包括近端，远端和横截面，所述细长的第一部分的尺寸被设计为递送到穿过组织的穿刺中， 第一部分结束。 第一部分可以由冷冻干燥的水凝胶形成，该冷冻干燥的水凝胶在暴露于穿刺内的生理流体时膨胀。 第二部分可以由固体块的非冻干的非交联水凝胶前体形成，前体保持非反应性状态直至暴露于生理水溶液中，随后前体彼此原位交联以提供 结合到第一部分的粘合剂层。 还提供了用于将密封剂穿过组织输送穿刺的装置和方法。

公开(公告)号：WO2012100091A2

公开(公告)日：2012-07-26

申请号：PCT/US2012/021920

申请日：2012-01-19

Applicant: ACCESSCLOSURE, INC. ,  UCHIDA, Andy, H. ,  SPIZUOCO, Anthony, P. ,  TO, Kevin ,  LIM, Florencia ,  SERSHEN, Scott, R.

Inventor： UCHIDA, Andy, H. ,  SPIZUOCO, Anthony, P. ,  TO, Kevin ,  LIM, Florencia ,  SERSHEN, Scott, R.

IPC: A61B17/08 ,  A61B17/10 ,  B32B9/00

CPC classification number: A61B17/0057 ,  A61B90/90 ,  A61B2017/00495 ,  A61B2017/00526 ,  A61B2017/00561 ,  A61B2017/0065 ,  A61B2017/00871 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00951 ,  A61B2017/22067 ,  A61B2017/22069 ,  A61L24/02 ,  C08L71/02

Abstract: A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.

Abstract translation: 提供密封剂用于密封通过组织的穿刺，所述组织包括细长的第一部分，所述细长的第一部分包括近端，远端以及尺寸适于通过组织输送穿刺的横截面，以及与所述远端 第一部分结束。 第一部分可以由冻干的水凝胶形成，其在暴露于穿刺期间的生理流体时膨胀。 第二部分可以由固体物质的非冷冻干燥的未交联水凝胶前体形成，前体保持在非活性状态，直到暴露于水性生理学，于是前体彼此原位交联以提供 粘合到第一部分的粘合剂层。 还提供了用于将密封剂输送穿过组织穿刺的装置和方法。

公开(公告)号：WO2010123755A1

公开(公告)日：2010-10-28

申请号：PCT/US2010/031275

申请日：2010-04-15

Applicant: XLUMENA, INC. ,  PHAN, Hoang ,  LUNSFORD, John ,  SANDER, Fiona ,  TO, Kevin ,  ALLEN, Michael

Inventor： PHAN, Hoang ,  LUNSFORD, John ,  SANDER, Fiona ,  TO, Kevin ,  ALLEN, Michael

IPC: A61M31/00

CPC classification number: A61B1/018 ,  A61B1/00082 ,  A61B5/6882 ,  A61B17/320016 ,  A61B17/3209 ,  A61B2017/00278 ,  A61B2017/22042 ,  A61B2017/22044 ,  A61B2017/22047 ,  A61B2017/22048 ,  A61B2017/3484 ,  A61M25/09 ,  A61M2025/09008 ,  A61M2025/09125 ,  A61M2025/09183

Abstract: A guidewire has a guidewire body with a distal end and a proximal end. A balloon or other tissue anchor is disposed at or near the distal end of the guidewire, and the guidewire may be used to draw two layers of tissue into apposition by placing the guidewire through a tissue penetration, deploying the tissue anchor, and drawing proximally on the guidewire body. Optionally, the guidewire may include deployable blades for enlarging a tissue penetration as the guidewire is advanced therethrough.

Abstract translation: 导丝具有带有远端和近端的导丝体。 气球或其他组织锚固件设置在导丝的远端处或附近，并且导丝可用于通过将导丝穿过组织穿透，展开组织锚固件并向近侧拉伸而将两层组织拉平 导丝体。 可选地，导丝可以包括可展开的刀片，用于当导丝从其穿过时扩大组织穿透。

公开(公告)号：WO2012178073A1

公开(公告)日：2012-12-27

申请号：PCT/US2012/043832

申请日：2012-06-22

Applicant: ACCESSCLOSURE, INC. ,  HASSAN, Ali ,  TO, Kevin ,  UCHIDA, Andy ,  GARCIA, Jose ,  YANG, Yi

Inventor： HASSAN, Ali ,  TO, Kevin ,  UCHIDA, Andy ,  GARCIA, Jose ,  YANG, Yi

IPC: A61M25/09

CPC classification number: A61M25/09 ,  A61M25/002 ,  A61M25/10185 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/09125 ,  A61M2025/09175

Abstract: A method of reducing the risk of clinical sequelae to catheter induced vascular injuries may include introducing a guide wire into a vascular sheath residing in a blood vessel, proximally retracting the vascular sheath while leaving the wire in place, and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may further involve proximally retracting the guide wire to position the inflatable balloon adjacent the injury and inflating the balloon to reduce blood flow past the injury, while leaving the guide wire in place to provide subsequent access to the injury.

Abstract translation: 减少导管引起的血管损伤的临床后遗症的风险的方法可包括将引导线引入位于血管中的血管鞘中，使血管鞘向近端缩回，同时留下线的存在或不存在 通过血管鞘引起血管的血管损伤或先前通过血管鞘的手术导管。 如果观察到血管损伤的标记，则该方法可进一步包括向近端缩回导丝以将可膨胀气囊定位在伤害附近并使气囊膨胀以减少血液流过损伤，同时将引导线放置在适当位置以提供随后的进入 受伤。