公开(公告)号：WO2005011905A1

公开(公告)日：2005-02-10

申请号：PCT/US2004/023444

申请日：2004-07-21

Applicant: HONEYWELL INTERNATIONAL INC. ,  LOUTHAN, Gary, R. ,  TRAN, Loc

Inventor： LOUTHAN, Gary, R. ,  TRAN, Loc

IPC: B23C3/18

CPC classification number: B23Q3/12 ,  B23B31/202 ,  B23B2215/76 ,  B23B2231/2027 ,  B23B2231/2043 ,  B23Q3/062 ,  Y10T29/49316 ,  Y10T29/49995 ,  Y10T82/10 ,  Y10T279/26 ,  Y10T279/29 ,  Y10T279/3487

Abstract: There is provided a locator device (20) and an associated fixture (10) a d method for supporting a rotatable member (100). The locator device (20) has base (22) and a plurality of flanges (24) extending from the base (22) in an axial direction and arranged circumferentially to define an aperture (25) for at least partially receiving the rotatable member (100) axially. The flanges (24) define slots (26) for receiving radial portions (110) of the rotatable member (100) wit the radial portions (110) extending radially outward from the flanges (24). Thus, the locator device (20) can support boreless rotatable members so that a tool (80) can be supported against the radial portions (110) of the rotatable member (100) to thereby form the rotatable member (100) to predetermined dimensions.

Abstract translation: 提供了一种用于支撑可旋转构件（100）的定位装置（20）和相关联的固定装置（10）。 定位装置（20）具有底座（22）和沿轴向方向从底座（22）延伸的多个凸缘（24），并沿圆周方向布置以限定用于至少部分地容纳可旋转构件（100）的孔 ）。 凸缘（24）限定用于容纳可旋转构件（100）的径向部分（110）的狭槽（26），而从凸缘（24）径向向外延伸的径向部分（110）。 因此，定位装置（20）可以支撑无孔可旋转构件，使得工具（80）可以支撑在可旋转构件（100）的径向部分（110）上，从而将可旋转构件（100）形成为预定尺寸。

公开(公告)号：WO2021127120A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/065517

申请日：2020-12-17

Applicant: BIOWISH TECHNOLOGIES, INC. ,  CARPENTER, Richard S. ,  BARNES, Joella ,  CROCKETT, John Kennedy ,  TRAN, Loc H.

Inventor： CARPENTER, Richard S. ,  BARNES, Joella ,  CROCKETT, John Kennedy ,  TRAN, Loc H.

IPC: A01K61/59 ,  A01K61/13 ,  C02F1/68 ,  C02F1/50 ,  A23K10/12 ,  A23K10/18 ,  A23K10/30 ,  A23K10/33 ,  C02F2103/007 ,  C02F2303/04

Abstract: One aspect of the invention relates to a composition comprising: water, soybean, molasses, a mineral mixture, an enzyme, and a microbial mixture comprising Bacillus subtilis 34KLB. Another aspect of the invention relates to a fermented composition of the above composition.

公开(公告)号：WO2006074269A3

公开(公告)日：2006-09-14

申请号：PCT/US2006000261

申请日：2006-01-05

Applicant: SCHERING CORP ,  WU WENXUE ,  TRAN LOC THANH ,  D SA BOSCO ,  LIANG FENG ,  LEONG WILLIAM ,  LEE HONG-CHANG ,  KLOPFER KEVIN ,  SABESEN VIJAY

Inventor： WU WENXUE ,  TRAN LOC THANH ,  D SA BOSCO ,  LIANG FENG ,  LEONG WILLIAM ,  LEE HONG-CHANG ,  KLOPFER KEVIN ,  SABESEN VIJAY

IPC: C07D401/06

CPC classification number: C07D401/14

Abstract: The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.

Abstract translation: 本发明一般涉及通过创造性地选择酸和溶剂介质来直接制备相对于选择的碱性化合物的旋转异构酸盐富集的药学上可接受的盐的方法。 该方法在制备旋转异构体所需优势的药学上有用的盐的特定旋转异构体时特别有用。

公开(公告)号：WO2006074270A3

公开(公告)日：2006-07-13

申请号：PCT/US2006/000262

申请日：2006-01-05

Applicant: SCHERING CORPORATION ,  WU, Wenxue ,  D'SA, Bosco ,  LIANG, Feng ,  TRAN, Loc, Thanh ,  LEONG, William ,  DAHANUKAR, Vilas ,  ZAVIALOV, Ilia, A. ,  ORR, Cecilia ,  ZHAO, Shannon ,  LEE, Hong-chang ,  LIU, Yi ,  NGUYEN, Hoa, N. ,  SHIH, Xiongwei ,  ZHU, Man

Inventor： WU, Wenxue ,  D'SA, Bosco ,  LIANG, Feng ,  TRAN, Loc, Thanh ,  LEONG, William ,  DAHANUKAR, Vilas ,  ZAVIALOV, Ilia, A. ,  ORR, Cecilia ,  ZHAO, Shannon ,  LEE, Hong-chang ,  LIU, Yi ,  NGUYEN, Hoa, N. ,  SHIH, Xiongwei ,  ZHU, Man

IPC: C07D401/14 ,  C07D211/26

Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

公开(公告)号：WO2006074270A2

公开(公告)日：2006-07-13

申请号：PCT/US2006000262

申请日：2006-01-05

Applicant: SCHERING CORP ,  WU WENXUE ,  D SA BOSCO ,  LIANG FENG ,  TRAN LOC THANH ,  LEONG WILLIAM ,  DAHANUKAR VILAS ,  ZAVIALOV ILIA A ,  ORR CECILIA ,  ZHAO SHANNON ,  LEE HONG-CHANG ,  LIU YI ,  NGUYEN HOA N ,  SHIH XIONGWEI ,  ZHU MAN

Inventor： WU WENXUE ,  D SA BOSCO ,  LIANG FENG ,  TRAN LOC THANH ,  LEONG WILLIAM ,  DAHANUKAR VILAS ,  ZAVIALOV ILIA A ,  ORR CECILIA ,  ZHAO SHANNON ,  LEE HONG-CHANG ,  LIU YI ,  NGUYEN HOA N ,  SHIH XIONGWEI ,  ZHU MAN

IPC: C07D401/14 ,  C07D211/26

CPC classification number: C07D211/96 ,  C07D211/26 ,  C07D401/14

Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

Abstract translation: 本发明涉及4- [4 - [（R） - [1- [环丙基磺酰基] -4-哌啶基]（3-氟苯基）甲基] -3（S） - 甲基-1-哌嗪基] 1 - [（4,6-二甲基-5-嘧啶基）羰基] -4-甲基哌啶]，以及通过新途径从容易获得的起始原料中间产物。

公开(公告)号：WO2006074269A2

公开(公告)日：2006-07-13

申请号：PCT/US2006/000261

申请日：2006-01-05

Applicant: SCHERING CORPORATION ,  WU, Wenxue ,  TRAN, Loc, Thanh ,  D'SA, Bosco ,  LIANG, Feng ,  LEONG, William ,  LEE, Hong-Chang ,  KLOPFER, Kevin ,  SABESEN, Vijay

Inventor： WU, Wenxue ,  TRAN, Loc, Thanh ,  D'SA, Bosco ,  LIANG, Feng ,  LEONG, William ,  LEE, Hong-Chang ,  KLOPFER, Kevin ,  SABESEN, Vijay

CPC classification number: C07D401/14

Abstract: The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.

Abstract translation: 本发明一般涉及通过创造性地选择酸和溶剂介质直接制备相对于所选择的碱性化合物的旋转异构体盐富集的药学上可接受的盐的方法。 该方法在制备特定的旋转异构体占优势的可药用盐的特定旋转异构体方面特别有用。

公开(公告)号：WO2005054245A3

公开(公告)日：2005-08-11

申请号：PCT/US2004039847

申请日：2004-11-29

Applicant: SCHERING CORP ,  KUO SHEN-CHUN ,  TRAN LOC THANH ,  ZHANG PENGYI

Inventor： KUO SHEN-CHUN ,  TRAN LOC THANH ,  ZHANG PENGYI

IPC: C07D487/14 ,  C07D487/00

CPC classification number: C07D487/14

Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed.

Abstract translation: 公开了一种在7-位具有氨基烷基取代基的取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c]嘧啶化合物的制备方法。

公开(公告)号：WO2005054245A2

公开(公告)日：2005-06-16

申请号：PCT/US2004/039847

申请日：2004-11-29

Applicant: SCHERING CORPORATION ,  KUO, Shen-Chun ,  TRAN, Loc, Thanh ,  ZHANG, Pengyi

Inventor： KUO, Shen-Chun ,  TRAN, Loc, Thanh ,  ZHANG, Pengyi

IPC: C07D487/00

CPC classification number: C07D487/14

Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed.

Abstract translation: 制备在7处具有氨基烷基取代基的取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并[1,5-c]嘧啶化合物的方法 披露。

公开(公告)号：WO2005044819A1

公开(公告)日：2005-05-19

申请号：PCT/US2004/035472

申请日：2004-10-26

Applicant: SCHERING CORPORATION? ,  KUO, Shen-Chun? ,  TSAI, David, Jieh-Shyh? ,  TRAN, Loc, Thanh? ,  ZHANG, Pengyi? ,  JONES, Andrew, D.?

Inventor： KUO, Shen-Chun? ,  TSAI, David, Jieh-Shyh? ,  TRAN, Loc, Thanh? ,  ZHANG, Pengyi? ,  JONES, Andrew, D.?

IPC: C07D487/14

CPC classification number: C07D487/14

Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.

Abstract translation: 公开了一种在7-位具有氨基烷基取代基的取代的5-氨基 - 吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c]嘧啶化合物的制备方法，其中嘧啶 环使用氰化剂环化。