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    REAL TIME MONITORING OF SMALL PARTICLE DISSOLUTION BY WAY OF LIGHT SCATTERING
    3.
    发明申请
    REAL TIME MONITORING OF SMALL PARTICLE DISSOLUTION BY WAY OF LIGHT SCATTERING 审中-公开
    通过光散射的方式实时监测小颗粒溶解

    公开(公告)号：WO2004013618A1

    公开(公告)日：2004-02-12

    申请号：PCT/US2003/021883

    申请日：2003-07-14

    Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  TUCKER, Christopher, J.

    Inventor： TUCKER, Christopher, J.

    IPC: G01N21/51

    CPC classification number: G01N33/15 ,  G01N15/0205 ,  G01N21/51 ,  G01N2013/006 ,  G01N2015/0693

    Abstract: A method for determining the percent of a solid material dissolved into a liquid medium is disclosed. The method comprises the steps of combining the solid material and the liquid medium; determining the initial solid concentration (i); determining the dynamic solid concentration (d) using a light scattering technique; and calculating the percent dissolved material according to the formula: [(i - d)/i] x 100 . Methods for determining dissolution rate and particle size using turbidity measurements are also disclosed.

    Abstract translation: 公开了一种确定溶解在液体介质中的固体材料的百分比的方法。 该方法包括将固体材料与液体介质结合的步骤; 确定初始固体浓度（i）; 使用光散射技术确定动态固体浓度（d）; 并根据以下公式计算溶解的百分比：[（i-d）/ i]×100。 还公开了使用浊度测量来确定溶解速率和粒径的方法。

    DI-SUBSTITUTED SURFACTANT PRECURSORS AND DERIVED SURFACTANTS
    4.
    发明申请
    DI-SUBSTITUTED SURFACTANT PRECURSORS AND DERIVED SURFACTANTS 审中-公开
    二取代的表面活性剂前体和衍生的表面活性剂

    公开(公告)号：WO2003037837A2

    公开(公告)日：2003-05-08

    申请号：PCT/US2002/033672

    申请日：2002-10-22

    Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  TUCKER, Christopher, J. ,  KALANTAR, Thomas, H. ,  KUMAR, Promod ,  STRANDBURG, Gary, M.

    Inventor： TUCKER, Christopher, J. ,  KALANTAR, Thomas, H. ,  KUMAR, Promod ,  STRANDBURG, Gary, M.

    IPC: C07C43/11

    CPC classification number: C11D1/72 ,  C07C43/11 ,  C07C305/10 ,  C11D1/29

    Abstract: This invention is for di-substituted surfactant precursors, surfactants prepared from them, methods of making the di-substituted surfactant precursors and derived surfactants, and to surfactants having the properties of the described surfactants. The di-substituted surfactant precursors and surfactants are derived from admixing water, surfactant, a hydrolysis catalyst, and an initial quantity of a substituted three-membered heterocycle (a substituted l-oxacyclopropane, a substituted 1-thiacyclopropane, or a substituted l-azacyclopropane) and sustaining an emulsion admixture of the di-substituted surfactant precursor, the water, the heterocycle, the surfactant, and the catalyst to yield the di-substituted surfactant precursor. The di-substituted surfactant precursor is further functionalized to achieve desired hydrophilic properties. A new surfactant product is ultimately provided affording a new combination of (in aqueous admixture) critical micelle concentration, viscosity, and clarity properties.

    Abstract translation: 本发明涉及二取代的表面活性剂前体，由它们制备的表面活性剂，制备二取代的表面活性剂前体和衍生的表面活性剂的方法以及具有所述表面活性剂性质的表面活性剂。 二取代的表面活性剂前体和表面活性剂来自混合水，表面活性剂，水解催化剂和初始量的取代的三元杂环（取代的1-氧杂环丙烷，取代的1-硫杂环丙烷或取代的1-氮杂环丙烷 ）并保持二取代的表面活性剂前体，水，杂环，表面活性剂和催化剂的乳液混合物，得到二取代的表面活性剂前体。 二取代的表面活性剂前体进一步官能化以获得所需的亲水性质。 最终提供新的表面活性剂产物，提供（水性混合物）临界胶束浓度，粘度和透明度性质的新组合。

    A THERMALLY-STABLE DIELECTRIC FLUID
    5.
    发明申请
    A THERMALLY-STABLE DIELECTRIC FLUID 审中-公开
    一种热稳定的电介质流体

    公开(公告)号：WO2012037366A1

    公开(公告)日：2012-03-22

    申请号：PCT/US2011/051787

    申请日：2011-09-15

    Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  HAN, Suh Joon ,  SCHMIDT, Dale C. ,  TUCKER, Christopher J.

    Inventor： HAN, Suh Joon ,  SCHMIDT, Dale C. ,  TUCKER, Christopher J.

    IPC: C08K5/13 ,  C08K5/18 ,  H01B3/20

    CPC classification number: H01B3/20 ,  C08K5/13 ,  C08K5/18 ,  Y10T29/49002

    Abstract: The disclosure is directed to a thermally-stable dielectric fluid. The dielectric fluid includes (a) an oil, (b) a substituted, hindered phenolic antioxidant having at least two substituted cresol groups being covalently bonded to each other through a methylene bridge, and (c) a substituted, diphenyl amine antioxidant having at least two substituted phenyl groups being covalently bonded to each other through an amine bridge.

    Abstract translation: 本公开涉及热稳定介电流体。 介电流体包括（a）油，（b）具有至少两个取代的甲酚基团的取代的受阻酚类抗氧化剂，其通过亚甲基桥基彼此共价键合，和（c）至少具有取代的二苯胺抗氧化剂 两个取代的苯基通过胺桥相互共价键合。

    CRYSTALLINE DRUG PARTICLES PREPARED USING A CONTROLLED PRECIPITATION PROCESS
    6.
    发明申请
    CRYSTALLINE DRUG PARTICLES PREPARED USING A CONTROLLED PRECIPITATION PROCESS 审中-公开
    使用控制退化方法制备的晶体药物颗粒

    公开(公告)号：WO2004012711A1

    公开(公告)日：2004-02-12

    申请号：PCT/US2003/021884

    申请日：2003-07-14

    Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  TUCKER, Christopher, J. ,  SVENSON, Sonke ,  HITT, James, E. ,  CURTIS, Cathy, A.

    Inventor： TUCKER, Christopher, J. ,  SVENSON, Sonke ,  HITT, James, E. ,  CURTIS, Cathy, A.

    IPC: A61K9/14

    CPC classification number: A61K9/146

    Abstract: Drug particles which are essentially crystalline and have a mean particle size below 2 microns, when dispersed in water, are described. When added to an aqueous medium at 25-95% of the equilibrium solubility of the drug substance, the drug particles show complete dissolution, as characterized by a 95% reduction in turbidity, in less than 5 minutes. Using a controlled precipitation process to prepare such drug particles is also described. Such drug particles exhibit an enhanced dissolution rate and better stability as compared to particles prepared according to processes described in the prior art.

    Abstract translation: 描述了当分散在水中时基本上是结晶的并且具有低于2微米的平均粒度的药物颗粒。 当以25-95％的药物物质的平衡溶解度加入到水性介质中时，药物颗粒显示完全溶解，其特征在于在不到5分钟内95％的浊度降低。 还描述了使用受控沉淀法制备这种药物颗粒。 与根据现有技术中描述的方法制备的颗粒相比，这样的药物颗粒显示出增强的溶解速率和更好的稳定性。

    ENCAPSULATED POLAR MATERIALS AND METHODS OF PREPARATION
    8.
    发明申请
    ENCAPSULATED POLAR MATERIALS AND METHODS OF PREPARATION 审中-公开
    包埋极性材料和制备方法

    公开(公告)号：WO2012166884A2

    公开(公告)日：2012-12-06

    申请号：PCT/US2012040158

    申请日：2012-05-31

    Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  DRAKE IAN ,  HUGHES ANDREW ,  TUCKER CHRISTOPHER J ,  KALANTAR THOMAS H ,  KATZ JOSHUA

    Inventor： DRAKE IAN ,  HUGHES ANDREW ,  TUCKER CHRISTOPHER J ,  KALANTAR THOMAS H ,  KATZ JOSHUA

    IPC: A61K9/48

    CPC classification number: C12N11/04 ,  A01N25/28 ,  A61K8/11 ,  A61K9/5031 ,  A61K2800/10 ,  A61Q19/00 ,  B01J13/06 ,  B01J13/16 ,  B01J13/18 ,  B01J13/185

    Abstract: The present invention meets one or more of the above needs and is a composition comprising plurality of capsules wherein the capsules comprise: a core of one or more highly polar liquids; one or more polar active materials dissolved in or dispersed in one or more highly polar liquids; a mixture of one or more polymers and one of more highly polar liquids; or a mixture of one or more polymers, one or more highly polar liquids and one or more polar active materials, and a shell comprising, particles in a polymer matrix or particles; wherein the thickness of the shell is sufficient to prevent passage of the highly polar liquid or the active material through the shell or to control the rate passage of the highly polar liquid or the active material through the shell with the proviso that the one or more polymers may be located in the core, in the polymer matrix of the shell or both.

    Abstract translation: 本发明满足上述一个或多个需求，并且是包含多个胶囊的组合物，其中胶囊包含：一种或多种高极性液体的芯; 一种或多种溶于或分散在一种或多种高极性液体中的极性活性物质; 一种或多种聚合物和更高极性液体之一的混合物; 或一种或多种聚合物，一种或多种高极性液体和一种或多种极性活性物质的混合物，以及包含聚合物基质或颗粒中的颗粒的壳; 其中壳体的厚度足以防止高极性液体或活性物质通过壳体，或者控制高极性液体或活性材料通过壳体的速率通过，条件是一种或多种聚合物 可以位于核心中，在壳的聚合物基质中或两者中。

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