公开(公告)号：WO2023087033A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/079907

申请日：2022-11-15

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： KAPLAN, David, L. ,  STOUT, Andrew ,  YUEN, John, Jr. ,  RUBIO, Natalie

IPC: A23L13/00 ,  C12N5/10

Abstract: The present disclosure relates to cultured tissue, methods for production of the cultured tissue, e.g., cultured meat, that is not genetically modified. Further, the disclosure provides method of temporary immortalization of cells for propagation in vitro.

公开(公告)号：WO2023069711A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/047424

申请日：2022-10-21

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： BACHOVCHIN, William, W. ,  LAI, Hung-sen ,  WU, Wengen

IPC: C07K16/18 ,  A61K31/69 ,  A61K38/04 ,  A61K38/05 ,  A61K47/06 ,  A61K51/04 ,  A61P35/00

Abstract: Disclosed are compositions for delivering neutron capture agents to cells expressing fibroblast activation protein (FAP), which composition comprises an FAP binding moiety (FAP-bm) associated (covalently or non-covalently) with a neutron capture agent, wherein binding of the FAP-bm to FAP on the surface of a cell expressing FAP results in FAP-dependent localization of the neutron capture agent to tissue expressing FAP.

公开(公告)号：WO2023288130A1

公开(公告)日：2023-01-19

申请号：PCT/US2022/037469

申请日：2022-07-18

Applicant: EXOSOME DIAGNOSTICS, INC. ,  TRUSTEES OF TUFTS COLLEGE ,  CHAKRABORTTY, Sudipto K. ,  LANG, Steven ,  KHODOR, Yevgenia ,  RAUSCHER, Martina ,  TADIGOTLA, Vasisht ,  YU, Wei ,  PAPAS, Athena ,  SKOG, Johan Karl Olov ,  HAYNES, Brian C. ,  XING, Shuran

Inventor： CHAKRABORTTY, Sudipto K. ,  LANG, Steven ,  KHODOR, Yevgenia ,  RAUSCHER, Martina ,  TADIGOTLA, Vasisht ,  YU, Wei ,  PAPAS, Athena ,  SKOG, Johan Karl Olov ,  HAYNES, Brian C. ,  XING, Shuran

IPC: C12Q1/6883

Abstract: The present disclosure is directed to methods of using salivary exosomes to detect and treat Sjögren's syndrome in a subject.

公开(公告)号：WO2022261550A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/033276

申请日：2022-06-13

Applicant: TRUSTEES OF TUFTS COLLEGE ,  Research Foundation Of The City University Of New York

Inventor： PANETTA, Karen, A. ,  AGAIAN, Sos, S. ,  TRONGTIRAKUL, Thaweesak

IPC: G06T9/00

Abstract: A method comprising: receiving a hyperspectral image of a scene; selecting one or more bands from the hyperspectral image; and processing the selected bands to produce a color image, wherein processing the selected bands to produce a color image includes: generating an LMS image by performing an RGB-to-LMS conversion on the selected bands; replacing a V-channel of an HSV image with an enhanced L-channel of the LMS image to produce a resultant HSV image, the HSV image being an image of the same scene as the hyperspectral image; and performing an HSV-to-RGB conversion on the resultant HSV image produces the color image.

公开(公告)号：WO2022174203A2

公开(公告)日：2022-08-18

申请号：PCT/US2022/070136

申请日：2022-01-11

Applicant: TRUSTEES OF TUFTS COLLEGE ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： OMENETTO, Fiorenzo, G. ,  MATZEU, Giusy ,  NAVEH, Gili

IPC: A61B10/00 ,  A61C19/04 ,  G01N21/77 ,  G01N21/78 ,  G01N21/80 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/04

Abstract: The present disclosure provides an oral sampling device for chemical examination of an oral cavity. The oral sampling device includes an oral sampling support substrate, and a bioresponsive interface coupled to the oral sampling support substrate. The bioresponsive interface is composed of a biopolymer matrix comprising a sensing agent. In some aspects, the bioresponsive interface undergoes a color change in response to an environmental parameter (e.g., pH value) in the region of interest in the oral cavity.

公开(公告)号：WO2022133190A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/063994

申请日：2021-12-17

Applicant: TRUSTEES OF TUFTS COLLEGE ,  RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK

Inventor： PANETTA, Karen, A. ,  PARAMATHMA RAO, Shishir ,  KAMATH KALASA MOHANDAS, Shreyas ,  RAJENDRAN, Rahul ,  RAJEEV, Srijith ,  HENNESSY, Erin ,  ECONOMOS, Christina ,  SHONKOFF, Eleanor, Tate ,  AGAIAN, Sos, S.

IPC: G16H20/60 ,  G06N20/00 ,  G06Q30/00 ,  G16H20/00

Abstract: The disclosure generally relates to the artificial intelligence (AI) automatic methods, computer program product, and systems and methodology for dietary and medical treatment planning, food waste estimation, analyzing three-dimensional food image construction, measurement, nutrient estimation, nutritional assessment, evaluation, prediction and management. More particularly, the embodiments described herein relate to utilizing an AI-based algorithm that can automatically, detect food items from images acquired by cameras for dietary assessment, dietary planning, and for estimating food waste. In one aspect, the method may include food calorie estimation techniques using machine learning and computer vision techniques for dietary assessment. In another aspect, the tools may apply to personalized nutrition. The method may also include the automation of nutrition planning. In yet another aspect, the tools may apply to medical treatment planning, wherein meals and treatment plans are individualized explicitly for each user according to several unique characteristics associated with that user.

公开(公告)号：WO2022046832A1

公开(公告)日：2022-03-03

申请号：PCT/US2021/047440

申请日：2021-08-25

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： WANG, Wei ,  SONKUSALE, Sameer

IPC: H03M1/66 ,  H03M1/68 ,  H03M1/74 ,  H03M1/76 ,  H03M1/78

Abstract: A digital-to-analog converter that outputs an analog value representing a digital value includes a decoding stage and an interpolation stage. The decoding stage defines upper and lower bounds and the interpolation stage outputs an interpolated value that is between the upper and lower bounds. The upper and lower bounds are based on a most-significant portion of the digital value. The interpolation stage selects the interpolated value based on the least-significant portion of the digital value.

公开(公告)号：WO2021232018A1

公开(公告)日：2021-11-18

申请号：PCT/US2021/032793

申请日：2021-05-17

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： LOUNDER, Samuel, J. ,  ASATEKIN, Ayse

IPC: A61L27/50 ,  B01D69/02 ,  B01D69/12 ,  B01D71/26 ,  C08F220/10 ,  C08F220/18

Abstract: Disclosed are copolymers, comprising a plurality of zwitterionic repeat units, and a plurality of hydrophobic repeat units, wherein the hydrophobic repeat units each independently comprises a cross-linkable moiety; the cross-linked copolymer network, comprising such copolymer; as well as thin film composite membrane comprising such cross-linked copolymer network.

公开(公告)号：WO2021195445A1

公开(公告)日：2021-09-30

申请号：PCT/US2021/024253

申请日：2021-03-25

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： KAPLAN, David, L. ,  KUMAR, Krishna Jr. ,  MONTANARI, Vittorio ,  HAWKER, Morgan ,  FOUNTAIN, Julia ,  WU, Junqi

IPC: A61K38/17 ,  C08L89/00 ,  D01F4/02

Abstract: The present disclosure relates to compositions, methods of making, and methods of using a modified silk-based composition having a selectively tunable hydrophobicity. The provided compositions include silk fibroin having a haloalkyl substituent. The haloalkyl substituent is coupled to an amino acid of the silk fibroin though a linking agent.

公开(公告)号：WO2021168060A1

公开(公告)日：2021-08-26

申请号：PCT/US2021/018491

申请日：2021-02-18

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： NAIR, Nikhil, Unni ,  MAYS, Zachary ,  MOHAN, Karishma ,  CHAPPELL, Todd ,  TRIVEDI, Vikas, D.

IPC: C12Q1/68 ,  C40B40/10 ,  C40B50/06 ,  D06M16/00 ,  D21H25/00 ,  D21H25/02

Abstract: Disclosed are methods, systems, components, and compositions for engineering enzymes. Particularly disclosed are methods, systems, components, and compositions for engineering phenylalanine ammonia-lyase (PAL) enzymes and isolating variant PAL enzymes with enhanced enzymatic properties. The variant PAL enzymes disclosed herein or obtained by the methods disclosed herein may be utilized for treating diseases or disorders characterized by elevated blood levels of phenylalanine, such as phenylketonuria (PKU).