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    METHOD FOR ANALYZING ACTIVATED POLYETHYLENE GLYCOL COMPOUNDS
    2.
    发明申请
    METHOD FOR ANALYZING ACTIVATED POLYETHYLENE GLYCOL COMPOUNDS 审中-公开
    分析活性聚乙烯甘油化合物的方法

    公开(公告)号：WO2006096535A1

    公开(公告)日：2006-09-14

    申请号：PCT/US2006/007670

    申请日：2006-03-03

    申请人： DOW GLOBAL TECHNOLOGIES INC. ,  WALLINGFORD, Ross, A. ,  TUROWSKI, Maciej

    发明人： WALLINGFORD, Ross, A. ,  TUROWSKI, Maciej

    IPC分类号： G01N30/88 ,  A61K47/48

    CPC分类号： G01N30/88 ,  A61K47/60 ,  G01N2030/8813 ,  G01N2030/8854 ,  Y10T436/200833 ,  Y10T436/2575

    摘要： A chemical analysis method for the determination Of RO(CH 2 CH 2 O) n H, RO(C 2 H 4 O) n A, and AO(C 2 H 4 O) n A in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an interger greater than 10. The method includes the step of chromatographing a sample of the mixture by liquid chromatography under critical conditions to determine the relative amounts Of RO(CH 2 CH 2 O)nH, RO(C 2 H 4 O) n A, and AO(C 2 H 4 O) n A in the mixture, hi addition a a chemical analysis method for the determination Of RO(CH 2 CH 2 O) n H, RO(C 2 H 4 O) n A, and AO(C 2 H 4 O) n A in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a biologically active material and n is an interger greater than 10. The method includes two steps. The first step is derivatizing the A groups of the mixture with a derivatizing agent to form a derivatized mixture comprising RO(CH 2 CH 2 O)nH , RO(C 2 H 4 O) n AD, and DAO(C 2 H 4 O) n AD , wherein AD is the derivatized A group. The second step is chromatographing a sample of the derivatized mixture by liquid chromatography under critical conditions to determine the relative amounts Of RO(CH 2 CH 2 O) n H, RO(C 2 H 4 O) n AD,and DAO(C 2 H 4 O) n AD in the derivatized mixture.

    摘要翻译： 用于确定RO（CH 2 CH 2 CH 2 O）n H，RO（C 2 H 2）的化学分析方法 O（C 2 H 4 O）n H 2， 其中R为烷基，A为与表面或生物活性物质偶联的官能团或其他使用的物质，n为大于10的整数。该方法包括步骤 在临界条件下通过液相色谱法对混合物的样品进行色谱分析，以确定RO（CH 2 CH 2 CH 2 O）n H，RO（C 2） O（C 2 H 4 O）