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    MOLECULE DETECTION USING BORONIC ACID SUBSTITUTED PROBES
    3.
    发明申请
    MOLECULE DETECTION USING BORONIC ACID SUBSTITUTED PROBES 审中-公开
    使用硼酸取代的探针的分子检测

    公开(公告)号：WO2015031399A1

    公开(公告)日：2015-03-05

    申请号：PCT/US2014/052765

    申请日：2014-08-26

    Applicant: TWO PORE GUYS, INC.

    Inventor： MORIN, Trevor

    IPC: C12P21/00 ,  C12N9/00

    CPC classification number: C07K14/003 ,  C12Q1/68 ,  C12Q1/6813 ,  G01N33/533 ,  C12Q2525/107 ,  C12Q2525/113 ,  C12Q2563/137 ,  C12Q2565/631

    Abstract: Provided are polymeric scaffold compositions and methods for detecting or quantitating diols such as carbohydrates or carbohydrate containing molecules (e.g., glycosylated protein). Provided herein are capture probes configured to bind to a scaffold. Also provided herein are capture probes linked to one or more reactive organoboronic moiety for binding diol-containing compounds in a solution. Methods of detecting complexes comprising diol-containing compounds for detecting or quantifying the presence of diol-containing compounds in solution using a nanopore device are also provided herein.

    Abstract translation: 提供了聚合物支架组合物和用于检测或定量二醇如碳水化合物或含碳水化合物的分子（例如糖基化蛋白质）的方法。 本文提供了构造成结合到支架的捕获探针。 本文还提供了与一种或多种反应性有机物部分连接的捕获探针，用于在溶液中结合含二醇的化合物。 本文还提供了检测包含含二醇化合物的复合物的方法，用于使用纳米孔装置检测或定量溶液中含二醇化合物的存在。

    TARGET SEQUENCE DETECTION BY NANOPORE SENSING OF SYNTHETIC PROBES
    5.
    发明申请
    TARGET SEQUENCE DETECTION BY NANOPORE SENSING OF SYNTHETIC PROBES 审中-公开
    合成探针纳米光感测目标序列检测

    公开(公告)号：WO2016049657A1

    公开(公告)日：2016-03-31

    申请号：PCT/US2015/052729

    申请日：2015-09-28

    Applicant: TWO PORE GUYS, INC.

    Inventor： MORIN, Trevor, J. ,  HELLER, Daniel, A.

    IPC: C12Q1/68

    CPC classification number: C12Q1/6825 ,  C12Q1/6816 ,  C12Q2525/107 ,  C12Q2565/607 ,  C12Q2565/631

    Abstract: Disclosed herein are methods and compositions for detection of one or more specific sequences of polynucleotides in a solution using a nanopore. In some embodiments, methods and compositions for identifying a polynucleotide in a sample or for target sequence detection of a polynucleotide are disclosed herein.

    Abstract translation: 本文公开了用于使用纳米孔在溶液中检测多核苷酸的一个或多个特定序列的方法和组合物。 在一些实施方案中，本文公开了用于鉴定样品中的多核苷酸或多核苷酸的靶序列检测的方法和组合物。

    WAFER-SCALE ASSEMBLY OF INSULATOR-MEMBRANE-INSULATOR DEVICES FOR NANOPORE SENSING
    7.
    发明申请
    WAFER-SCALE ASSEMBLY OF INSULATOR-MEMBRANE-INSULATOR DEVICES FOR NANOPORE SENSING 审中-公开
    绝缘体 - 膜 - 绝缘体器件用于纳米孔传感的晶片级组装

    公开(公告)号：WO2017165267A1

    公开(公告)日：2017-09-28

    申请号：PCT/US2017/023149

    申请日：2017-03-20

    Applicant: TWO PORE GUYS, INC.

    Inventor： LIU, Xu ,  ZHANG, Yuning ,  DUNBAR, William, B.

    IPC: H01L29/66 ,  G01N33/543 ,  B01L3/00

    Abstract: Described herein are nanopore devices as well as methods for assembling a nanopore device including one or more nanopores that can be used to detect molecules such as nucleic acids, amino acids (proteins), and the like. Specifically, a nanopore device includes an insulating layer that reduces electrical noise and thereby improves the sensing resolution of the one or more nanopores integrated within the nanopore device.

    Abstract translation: 本文描述了纳米孔装置以及用于组装纳米孔装置的方法，所述纳米孔装置包括可用于检测诸如核酸，氨基酸（蛋白质）等分子的一个或多个纳米孔。 具体而言，纳米孔装置包括绝缘层，该绝缘层降低电噪声并由此提高纳米孔装置内整合的一个或多个纳米孔的感测分辨率。

    MULTIPLEXED BIOMARKER QUANTITATION BY NANOPORE ANALYSIS OF BIOMARKER-POLYMER COMPLEXES
    9.
    发明申请
    MULTIPLEXED BIOMARKER QUANTITATION BY NANOPORE ANALYSIS OF BIOMARKER-POLYMER COMPLEXES 审中-公开
    生物标记聚合物复合物的纳米分析的多重生物标记定量

    公开(公告)号：WO2014210219A1

    公开(公告)日：2014-12-31

    申请号：PCT/US2014/044185

    申请日：2014-06-25

    Applicant: TWO PORE GUYS, INC.

    Inventor： MORIN, Trevor J.

    IPC: G01N33/00 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/68

    CPC classification number: G01N33/48721

    Abstract: Devices and methods for detecting a target molecule are provided herein. The methods entail contacting a sample with a polymer scaffold, the polymer comprising at least one association site configured to associate with the target molecule. The sample is brought into contact with the polymer to determine whether the target molecule is present in the sample under conditions allowing the target molecule, if present, to associate with the polymer scaffold. The methods further involve loading the polymer into a device comprising a pore or channel that connects two volumes, configuring the device to pass the polymer through the pore or channel from one volume to the other volume, and determining, with a sensor configured to detect objects passing through the pore or channel, whether the target molecule is associated with the association site, and thereby detecting the presence or absence of the target molecule in the sample.

    Abstract translation: 本文提供了用于检测靶分子的装置和方法。 所述方法需要使样品与聚合物支架接触，所述聚合物包含至少一个配位成与靶分子缔合的缔合位点。 使样品与聚合物接触以确定靶分子是否存在于样品中，允许目标分子（如果存在）与聚合物支架缔合的条件下。 所述方法还涉及将聚合物加载到包括连接两个体积的孔或通道的装置中，将所述装置配置成将所述聚合物通过所述孔或通道从一个体积传递到另一个体积，以及通过配置成检测物体的传感器来确定 通过孔或通道，靶分子是否与缔合位点相关联，从而检测样品中靶分子的存在或不存在。

    A METHOD OF BIOLOGICAL TARGET DETECTION USING A NANOPORE AND A FUSION PROTEIN BINDING AGENT
    10.
    发明申请
    A METHOD OF BIOLOGICAL TARGET DETECTION USING A NANOPORE AND A FUSION PROTEIN BINDING AGENT 审中-公开
    使用NANOPORE和FUSION蛋白结合剂的生物目标检测方法

    公开(公告)号：WO2014182634A1

    公开(公告)日：2014-11-13

    申请号：PCT/US2014/036861

    申请日：2014-05-05

    Applicant: TWO PORE GUYS, INC.

    Inventor： MORIN, Trevor J.

    IPC: G01N33/487 ,  C12Q1/68

    CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/4473 ,  G01N27/44791 ,  G01N33/5302 ,  G01N33/536 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/574 ,  B81C1/00158 ,  C12Q2563/116 ,  C12Q2563/131 ,  C12Q2565/531 ,  C12Q2565/631

    Abstract: Provided are methods for detecting a target molecule or particle suspected to be present in a sample, comprising (a) contacting the sample with (i) a fusion molecule comprising a ligand capable of binding to the target molecule or particle and a binding domain, and (ii) a polymer scaffold comprising at least one binding motif to which the binding domain is capable of binding, under conditions that allow the target molecule or particle to bind to the ligand and the binding domain to bind to the binding motif; (b) loading the polymer into a device comprising a pore that separates an interior space of the device into two volumes, and configuring the device to pass the polymer through the pore from one volume to the other volume, wherein the device further comprises a sensor adjacent to the pore configured to identify objects passing through the pore; and (c) determining, with the sensor, whether the fusion molecule or particle bound to the binding motif is bound to the target molecule or particle, thereby detecting the presence of the target molecule or particle in the sample.

    Abstract translation: 提供了用于检测疑似存在于样品中的靶分子或颗粒的方法，其包括（a）使样品与（i）包含能够结合靶分子或颗粒的配体和结合结构域的融合分子接触，以及 （ii）在允许靶分子或颗粒结合配体和结合结构域以结合结合基序的条件下，包含至少一个结合结构域能结合的结合基序的聚合物支架; （b）将聚合物加载到包括将装置的内部空间分成两个体积的孔的装置中，以及将所述装置构造成使所述聚合物通过所述孔从一个体积传递到另一个体积，其中所述装置还包括传感器 邻近孔被配置成识别通过孔的物体; 和（c）使用传感器确定与结合基序结合的融合分子或颗粒是否结合到靶分子或颗粒，从而检测样品中靶分子或颗粒的存在。

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