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1.发明申请POLYPEPTIDES DERIVED FROM ENTEROCOCCUS AND THEIR USE FOR VACCINATION AND THE GENERATION OF THERAPEUTIC ANTIBODIES 审中-公开来自肠套叠的多肽及其用于接种和产生治疗性抗体的用途
公开(公告)号：WO2015132103A2
公开(公告)日：2015-09-11
申请号：PCT/EP2015053948
申请日：2015-02-25
Inventor： HÜBNER JOHANNES , HARTKE AXEL , ROMERO FELIPE
IPC: A61K39/02
CPC classification number: A61K39/09 , A61K39/025 , A61K2039/572 , C07K14/24 , C07K16/1228 , C07K16/1267
Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
Abstract translation: 用于治疗或预防细菌感染的药物，其特征在于其含有至少一种选自SEQ ID NO：1至SEQ ID NO：9的多肽及其连续片段，其中所述至少一种多肽或 其连续片段在有此需要的患者中诱导调理性抗体。 根据本发明的多肽或其连续片段可用于制备抗肠球菌感染的疫苗。
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Patent Agency Ranking
公开(公告)号：WO2013010676A3
公开(公告)日：2013-08-29
申请号：PCT/EP2012003081
申请日：2012-07-20
Applicant: ENSCR , CENTRE NAT RECH SCIENT , UNIV CAEN BASSE NORMANDIE , MAUDUIT MARC , BORRE ETIENNE , CREVISY CHRISTOPHE , GAUMONT ANNIE-CLAUDE , DEZ ISABELLE , CLOUSIER NATHALIE , ENSICAEN
Inventor： MAUDUIT MARC , BORRE ETIENNE , CREVISY CHRISTOPHE , GAUMONT ANNIE-CLAUDE , DEZ ISABELLE , CLOUSIER NATHALIE
CPC classification number: B01J31/061 , B01J31/0284 , B01J31/0297 , B01J31/0298 , B01J31/165 , B01J31/2208 , B01J31/2273 , B01J31/2278 , B01J2231/543 , B01J2531/821 , B01J2540/42 , B01J2540/442 , B01J2540/68 , C07D233/58 , C08B37/003 , C08B37/0084 , C08L2205/18
Abstract: The present invention concerns a supported ionic liquid phase catalyst comprising a support and a catalyst dispersed in an ionic liquid on said support. The support comprises a biopolymer, preferably chitosan or alginate, and the catalyst is a metathesis catalyst, preferably a pyridinium-tagged Grubbs-Hoveyda II catalyst. Further, the present invention concerns a method of performing an olefin metathesis, in particular RCM. The method of the invention comprises the use of a supported ionic liquid phase catalyst. Furthermore, the present invention concerns the use of a supported ionic liquid phase catalyst in olefin metathesis reactions. Finally, the present invention also concerns an ionic liquid exhibiting a suitable adsorption to a biopolymer. The ionic liquid comprises [ButylMethyl-lmidazolium]X salts, wherein X is selected in the group consisting of PF6 or BF4 or PF3(C2F5)3.
Abstract translation: 本发明涉及一种支持的离子液相催化剂，其包括分散在所述载体上的离子液体中的载体和催化剂。 载体包括生物聚合物，优选壳聚糖或藻酸盐，并且催化剂是复分解催化剂，优选吡啶鎓标记的Grubbs-Hoveyda II催化剂。 此外，本发明涉及一种进行烯烃复分解的方法，特别是RCM。 本发明的方法包括使用负载型离子液相催化剂。 此外，本发明涉及负载型离子液相催化剂在烯烃复分解反应中的应用。 最后，本发明还涉及对生物聚合物表现出适当吸附的离子液体。 离子液体包含[丁基甲基咪唑鎓] X盐，其中X选自由PF 6或BF 4或PF 3（C 2 F 5）3组成的组。
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3.发明申请METHOD FOR MEASURING THE PLASMINE ACTIVITY OF MICROPARTICLES PRESENT IN A SAMPLE OF A BIOLOGICAL FLUID AND USE THEREOF 审中-公开测量生物流体样本中存在的微粒的血浆活性的方法及其用途
公开(公告)号：WO2009004189A3
公开(公告)日：2009-03-26
申请号：PCT/FR2008000767
申请日：2008-06-06
Applicant: INST NAT SANTE RECH MED , ASSIST PUBL HOPITAUX DE PARIS , UNIV AIX MARSEILLE II , UNIV CAEN BASSE NORMANDIE , ANGLES CANO EDUARDO , LACROIX ROMARIC , MALATERRE FLORENCE , DIGNAT-GEORGE FRANCOISE
Inventor： ANGLES CANO EDUARDO , LACROIX ROMARIC , MALATERRE FLORENCE , DIGNAT-GEORGE FRANCOISE
Abstract: The invention relates to a method for measuring the plasmine activity of microparticles, in particular circulating microparticles, in a sample of a biological fluid, particularly a biological fluid in a flow situation, wherein said method can be used as a diagnosis method or a method for following a treatment.
Abstract translation: 本发明涉及一种用于测量生物流体样本中的微粒尤其是循环微粒的血浆活性的方法，其中所述生物流体尤其是生物流体样本中的血浆微粒的血浆活性，其中所述方法可以用作诊断方法或方法 接受治疗。
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4.发明申请NEW MARINE-ORIGINATING BIOLOGICAL PRODUCT, METHOD FOR PRODUCING THE SAME AND USES THREOF 审中-公开新的海洋生物生物产品，其生产方法及其使用方法
公开(公告)号：WO2008046993A3
公开(公告)日：2008-10-09
申请号：PCT/FR2007001676
申请日：2007-10-15
Applicant: UNIV CAEN BASSE NORMANDIE UMR , LE BIHAN ESTELLE , KOUETA NOUSSITHE
Inventor： LE BIHAN ESTELLE , KOUETA NOUSSITHE
IPC: A23K1/10 , A23B4/033 , A23B4/22 , A23K1/18 , A23K3/00 , A23L1/325 , A23L1/333 , C12N1/20 , C12N5/00
CPC classification number: C12P21/06 , A23J1/002 , A23J1/04 , A23K10/26 , A23K30/20 , A23K50/80 , A23L17/50
Abstract: The invention pertains to the field of chemistry and more precisely to that of biology. The invention specifically relates to the silage (or liquefaction) of the digestive organs of a cephalopod, such as cuttlefish, under the influence of endogen enzymes during the freeze-drying silage into a powdered product that can be preserved. The invention can be used in aquaculture for improving the growth rate of juvenile fish, in bacteriology for producing additives for culture media, for micro-organism culture media or in he food industry for compensating a protein deficit.
Abstract translation: 本发明涉及化学领域，更精确地涉及生物学领域。 本发明特别涉及在冷冻干燥青贮过程中在内源性酶的作用下，头足类动物如乌贼的消化器官的青贮（或液化）成为可保存的粉末产品。 本发明可用于水产养殖，用于提高幼鱼的生长速率，用于生产培养基添加剂的细菌学，用于微生物培养基或用于食品工业以补偿蛋白质缺乏。
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5.发明申请SYNTHESIS OF INOSITOLPHOSPHATE GLYCAN MOLECULES: TREATMENT OF CELL PROLIFERATION DISORDERS AND METABOLIC DISORDERS CHARACTERIZED BY INSULIN RESISTANCE 审中-公开非酪氨酸糖苷分子的合成：胰岛素抵抗特征的细胞增殖性疾病和代谢障碍的治疗
公开(公告)号：WO03066647A2
公开(公告)日：2003-08-14
申请号：PCT/FR0300345
申请日：2003-02-05
Applicant: CNRS CT NAT DE RECH SCIENT , UNIV CAEN BASSE NORMANDIE , CHAPLEUR YVES JEAN MARCEL , BOGDANOWICZ PATRICK DIDIER , CHRETIEN FRANCOISE , PUJOL JEAN-PIERRE ANTOINE
Inventor： CHAPLEUR YVES JEAN MARCEL , BOGDANOWICZ PATRICK DIDIER , CHRETIEN FRANCOISE , PUJOL JEAN-PIERRE ANTOINE
CPC classification number: C07H11/04
Abstract: The invention concerns a compound of formula A wherein: R1 is selected from the group consisting of OH, an oligosaccharide, a polysaccharide, and R2=R3=OH; or at least one of the groups R1, R2, R3 is a group capable of modifying the lipophilicity of the compound A, the other or the other two of the three groups being OH; and R4 is selected from the group consisting of OH, NH2 and a group capable of modifying the lipophilicity of the compound A; and R6 is H or CH2OH; and X is selected among O, NH, S, CH2; and R5 is selected among OH, an oligosaccharide, a polysaccharide and a group capable of modifying the bioavailability of the compound A, and its pharmaceutically acceptable salts.
Abstract translation: 本发明涉及式A化合物，其中：R 1选自OH，寡糖，多糖，R 2 = R 3 = OH; 或R 1，R 2，R 3中的至少一个是能够改变化合物A的亲油性的基团，三个基团中的另一个或另外两个是OH; 并且R 4选自OH，NH 2和能够改变化合物A的亲油性的基团; 并且R 6是H或CH 2 OH; 并且X选自O，NH，S，CH 2; 并且R5选自OH，寡糖，多糖和能够改变化合物A的生物利用度的基团及其药学上可接受的盐。
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6.发明申请
公开(公告)号：WO2009004189A9
公开(公告)日：2009-05-14
申请号：PCT/FR2008000767
申请日：2008-06-06
Applicant: INST NAT SANTE RECH MED , ASSIST PUBL HOPITAUX DE PARIS , UNIV AIX MARSEILLE II , UNIV CAEN BASSE NORMANDIE , ANGLES CANO EDUARDO , LACROIX ROMARIC , MALATERRE FLORENCE , DIGNAT-GEORGE FRANCOISE
Inventor： ANGLES CANO EDUARDO , LACROIX ROMARIC , MALATERRE FLORENCE , DIGNAT-GEORGE FRANCOISE
Abstract: The invention relates to a method for measuring the plasmine activity of microparticles, in particular circulating microparticles, in a sample of a biological fluid, particularly a biological fluid in a flow situation, wherein said method can be used as a diagnosis method or a method for following a treatment.
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