公开(公告)号：WO2015183357A2

公开(公告)日：2015-12-03

申请号：PCT/US2015017059

申请日：2015-02-23

Applicant: UNIV MISSOURI

Inventor： JALISATGI SATISH S ,  HAWTHORNE MARION FREDERICK

IPC: A61K51/12 ,  A61K31/69

CPC classification number: A61K41/0095 ,  A61K9/127 ,  A61K31/69 ,  A61K47/6911 ,  A61N5/10 ,  A61N2005/109 ,  C07F5/05

Abstract: Provided herein are compositions and methods for boron neutron capture therapy. In particular, the disclosure relates to therapy using liposomal Na3[1-(2'-B10H9)-2-NH3B10H8] and K[nido-7-CH3(CH2)15-7,8-C2B9H11] sources.

Abstract translation: 本文提供了硼中子捕获治疗的组合物和方法。 具体地，本公开涉及使用脂质体Na 3 [1-（2'-B 10 H 9）2 -NH 3 B 10 H 8]和K [Nido-7-CH 3（CH 2）15 -7,8-C 2 B 9 H 11]源的治疗。

公开(公告)号：WO2013142200A1

公开(公告)日：2013-09-26

申请号：PCT/US2013030923

申请日：2013-03-13

Applicant: UNIV MISSOURI ,  KANNAN RAGHURAMAN ,  ARTHUR GERALD ,  CALDWELL CHARLES W JR ,  CALDWELL CHARLES ,  CHANDA NRIPEN ,  ZAMBRE AJIT ,  RAMACHANDRAN MYTHILIL

Inventor： KANNAN RAGHURAMAN ,  ARTHUR GERALD ,  CALDWELL CHARLES W JR ,  CALDWELL CHARLES ,  CHANDA NRIPEN ,  ZAMBRE AJIT ,  RAMACHANDRAN MYTHILIL

IPC: C07K7/08 ,  C07K17/14 ,  G01N33/68

CPC classification number: G01N33/6872 ,  C07K7/08 ,  C07K14/71 ,  C07K17/14 ,  G01N33/54346 ,  G01N2333/485

Abstract: An embodiment of the invention is a peptide comprising four domains, wherein domain I consists of thioctyl or monocytl, domain II consists of 2 to 3 positively charged amino acids selected from the group consisting of lysine and arginine, domain III consists of a dimeric ethylene unit; and domain IV comprises the peptide with SEQ ID No. 1 or a sequence having at least 90% identity to SEQ ID No. I. The peptide is preferably attached to a gold nanostructure, preferably a gold nanorod to provide an EFGR kit. An EFGR detection kit of the invention employs a gold nanostructure attached to a peptide sequence, the peptide sequence includes a binding sequence with an affinity toward EGFR, a ligand bound to gold atoms of the nanorod, a positively charged amino acid that maintains activity of the binding sequence, and a unit that increases hydrophilicity of the peptide sequence.

Abstract translation: 本发明的一个实施方案是包含四个结构域的肽，其中结构域I由硫辛基或单核细胞集合组成，结构域II由选自赖氨酸和精氨酸的2至3个带正电荷的氨基酸组成，结构域III由二聚乙烯单元 ; 并且结构域IV包含具有SEQ ID No.1的肽或与SEQ ID No.1具有至少90％同一性的序列。肽优选连接到金纳米结构，优选金纳米棒以提供EFGR试剂盒。 本发明的EFGR检测试剂盒采用与肽序列连接的金纳米结构，肽序列包括与EGFR亲和力的结合序列，与纳米棒的金原子结合的配体，维持活性的带正电荷的氨基酸 结合序列和增加肽序列的亲水性的单元。

公开(公告)号：WO2013033524A2

公开(公告)日：2013-03-07

申请号：PCT/US2012053325

申请日：2012-08-31

Applicant: UNIV MISSOURI ,  HEISE DAVID ,  ROSALES LICET ,  SKUBIC MARJORIE

Inventor： HEISE DAVID ,  ROSALES LICET ,  SKUBIC MARJORIE

IPC: A61B5/024

CPC classification number: A61B5/0205 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/1102 ,  A61B5/113 ,  A61B5/6892 ,  A61B5/72 ,  A61B2562/0247

Abstract: Disclosed herein is a new and improved non-invasive bed sensing system for detecting and monitoring physiological movements such as heartbeat and respiration. The system may employ a hydraulic fluid to transduce the physiological pressures to an integrated pressure sensor and a new and improved signal processing method to identify individual cardiac pulses from the electronic signals generated by the hydraulic transducer. The system provides increased sensitivity capable of capturing quantitative pulse and respiration rates with subtle changes, ability to distinguish between instances of low pulse rate and shallow breathing, and improved comfort over existing system.

Abstract translation: 本文公开了一种新的和改进的非侵入性床感测系统，用于检测和监测诸如心跳和呼吸的生理运动。 该系统可以使用液压流体将生理压力转换成集成的压力传感器和新的改进的信号处理方法，以从由液压换能器产生的电子信号中识别各个心脏脉冲。 该系统提供增强的灵敏度，能够捕捉定量脉冲和呼吸速率，微妙的变化，区分低脉搏和浅呼吸的情况，以及改善现有系统的舒适度。

公开(公告)号：WO2013016547A2

公开(公告)日：2013-01-31

申请号：PCT/US2012048357

申请日：2012-07-26

Applicant: UNIV MISSOURI ,  FORGACS GABOR ,  MARGA FRANCOISE ,  JAKAB KAROLY ROBERT

Inventor： FORGACS GABOR ,  MARGA FRANCOISE ,  JAKAB KAROLY ROBERT

IPC: A23L1/31 ,  A23L1/317

CPC classification number: A23L13/00 ,  A23L13/03 ,  C12M21/08 ,  C12N5/0062 ,  C12N5/0697 ,  C12N2502/1347 ,  C12N2502/28 ,  C12N2506/1307 ,  C12N2533/76

Abstract: Provided are engineered meat products formed as a plurality of at least partially fused layers, wherein each layer comprises at least partially fused multicellular bodies comprising non-human myocytes and wherein the engineered meat is comestible. Also provided are multicellular bodies comprising a plurality of non-human myocytes that are adhered and/or cohered to one another; wherein the multicellular bodies are arranged adjacently on a nutrient- permeable support substrate and maintained in culture to allow the multicellular bodies to at least partially fuse to form a substantially planar layer for use in formation of engineered meat. Further described herein are methods of forming engineered meat utilizing said layers.

Abstract translation: 提供工程化肉制品，其形成为多个至少部分熔合的层，其中每个层包含至少部分融合的包含非人类肌细胞的多细胞体，并且其中工程化肉是可食用的。 还提供了包含相互粘附和/或粘附的多个非人类肌细胞的多细胞体; 其中所述多细胞体邻近地布置在营养渗透性支撑基底上并维持培养以允许所述多细胞体至少部分融合以形成用于形成工程化肉的基本平坦的层。 本文进一步描述了利用所述层形成工程化肉的方法。

公开(公告)号：WO2012109332A3

公开(公告)日：2012-12-06

申请号：PCT/US2012024299

申请日：2012-02-08

Applicant: UNIV MISSOURI ,  BARNETT MICHAEL A ,  DODAM JOHN R ,  MIDDLETON JOHN R ,  SHAW MIRANDA N ,  SIFUENTES XANDRA M

Inventor： BARNETT MICHAEL A ,  DODAM JOHN R ,  MIDDLETON JOHN R ,  SHAW MIRANDA N ,  SIFUENTES XANDRA M

IPC: A61D1/02 ,  A61J1/06 ,  A61M5/24

CPC classification number: A61M5/24 ,  A61B17/00491 ,  A61D1/02 ,  A61J1/062 ,  A61M5/001

Abstract: In various embodiments, the present disclosure provides an injection system (10) for injecting a fluidic treatment substance into an orifice of an animal. In various implementations the system comprises a treatment cartridge (14) having a hollow body (138) that is structured and operable to retain a treatment substance within the hollow body (138). The system further comprises a plunger assembly (18) structured and operable to removably retain the treatment cartridge (14) and controllably dispense the treatment substance from the treatment cartridge (14). In various implementations the injection system (10) can additionally include an injection site cleaning adaptor (22) that is removably connectable to the treatment cartridge (14) and is structured and operable to clean a site in which the treatment substance is to be injected.

Abstract translation: 在各种实施方案中，本公开提供了一种用于将流体处理物质注入动物孔中的注射系统（10）。 在各种实施方式中，该系统包括具有空心体（138）的处理盒（14），其被构造和操作以将处理物质保持在中空体（138）内。 所述系统还包括柱塞组件（18），所述柱塞组件（18）被构造和操作以可移除地保持所述处理盒（14）并且可控地从所述处理盒（14）分配所述处理物质。 在各种实施方案中，注射系统（10）还可以包括可移除地连接到治疗药筒（14）的注射部位清洁适配器（22），并且其被构造和操作以清洁其中要注射治疗物质的部位。

公开(公告)号：WO2012162487A2

公开(公告)日：2012-11-29

申请号：PCT/US2012039322

申请日：2012-05-24

Applicant: CATERPILLAR INC ,  UNIV MISSOURI ,  MEHTA VIRAL S ,  DU HONGLIU ,  NELSON BRYAN E ,  MANRING NOAH

Inventor： MEHTA VIRAL S ,  DU HONGLIU ,  NELSON BRYAN E ,  MANRING NOAH

IPC: F04B1/29 ,  F04B1/20

CPC classification number: F04B1/306

Abstract: A pump (28) is disclosed. The pump may have a housing (42), a body (46) rotatably disposed within the housing and at least partially defining a plurality of barrels (48), a plurality of plungers (50) associated with the plurality of barrels, and a swashplate (56) tiltable by a swivel torque to vary a displacement of the plurality of plungers relative to the plurality of barrels. The pump may also have a port plate (53) with an inlet port (72), a discharge port (74), and a protrusion (94). The port plate may be configured to engage an end of the rotatable body. The pump may further have at least one piston (90, 92)disposed within the housing and configured to selectively engage the protrusion of the port plate to rotate the port plate and adjust the swivel torque.

Abstract translation: 公开了一种泵（28）。 泵可以具有壳体（42），可旋转地设置在壳体内并且至少部分地限定多个筒（48）的主体（46），与多个筒相关联的多个柱塞（50）和斜盘 （56）可通过旋转扭矩倾斜，以改变多个柱塞相对于多个筒的位移。 泵还可以具有带有入口端口（72），排出口（74）和突起（94）的端口板（53）。 端口板可以构造成接合可旋转主体的端部。 所述泵还可以具有设置在所述壳体内的至少一个活塞（90,92），并且构造成选择性地接合所述端口板的突出部以使所述端口板旋转并调节所述旋转扭矩。

公开(公告)号：WO2012094529A3

公开(公告)日：2012-11-22

申请号：PCT/US2012020375

申请日：2012-01-05

Applicant: UNIV MISSOURI ,  MITCHUM MELISSA GOELLNER ,  KANDOTH PRAMOD KAITHERI ,  YECKEL GREG ,  ITHAL NAGABHUSHANA

Inventor： MITCHUM MELISSA GOELLNER ,  KANDOTH PRAMOD KAITHERI ,  YECKEL GREG ,  ITHAL NAGABHUSHANA

IPC: C07K14/415 ,  C12N15/82

CPC classification number: C12N15/8285 ,  C07K14/415 ,  Y02A40/164

Abstract: To gain new insights into the mechanism of soybean resistance to the soybean cyst nematode (Heterodera glycines), gene expression profiles of developing syncytia in soybean near-isogenic lines (NILs) differing at the at Rhg1 locus were compared. Gene expression profiling revealed that 1,447 genes were differentially expressed between the line that is resistant to SCN and the line that is sensitive to SCN infection. These results indicate that syncytia induced in the resistant line are undergoing severe oxidative stress and imbalanced endoplasmic reticulum homeostasis, both of which likely contribute to the resistance reaction. Defense-related genes up-regulated within syncytia of the resistant line included those predominantly involved in apoptotic cell death, the plant hypersensitive response, and salicylic acid (SA)-mediated defense signaling; many of these genes were partially suppressed by a virulent soybean cyst nematode population for successful nematode reproduction and development on the resistant line. Expression of these SCN responsive genes may be manipulated to obtain SCN resistant lines.

Abstract translation: 为了获得大豆对大豆胞囊线虫（Heterodera glycines）抗性机制的新见解，比较了在Rhg1基因座处不同的大豆近等基因系（NIL）中发育合胞体的基因表达谱。 基因表达谱分析显示，在对SCN有抗性的品系和对SCN感染敏感的品系之间差异表达了1447个基因。 这些结果表明，在抗性系中诱导的合胞体正在经历严重的氧化应激和内质网平衡不平衡，这两者都可能有助于抗性反应。 在抗性系的合胞体中上调的防御相关基因包括主要参与凋亡细胞死亡，植物超敏反应和水杨酸（SA）介导的防御信号传导的那些基因; 许多这些基因被强毒大豆胞囊线虫种群部分抑制，以用于成功的线虫繁殖和抗性品系的发育。 可以操纵这些SCN应答基因的表达以获得SCN抗性系。

公开(公告)号：WO2012009578A3

公开(公告)日：2012-04-05

申请号：PCT/US2011044082

申请日：2011-07-14

Applicant: UNIV MISSOURI ,  GU LI-QUN ,  WANG YONG ,  TIAN KAI

Inventor： GU LI-QUN ,  WANG YONG ,  TIAN KAI

IPC: C12Q1/68

CPC classification number: C12Q1/6825 ,  C12Q1/6886 ,  C12Q2600/178 ,  G01N33/48721 ,  C12Q2523/307 ,  C12Q2525/161 ,  C12Q2525/207 ,  C12Q2565/631

Abstract: The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3' terminus, 5' terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.

Abstract translation: 本发明提供了基于纳米孔技术的新型和改进的寡核苷酸检测方法，其中探针含有与靶寡核苷酸互补的序列以及在探针3'末端，5'末端或两个末端处的末端延伸。 带有探针的改进的纳米孔传感器可以对目标寡核苷酸如miRNA进行灵敏，选择性和直接的检测，分化和定量。 基于患者血液样品中的miRNA水平，本发明的检测方法还可以用作用于癌症检测的非侵入性和成本有效的诊断方法。

公开(公告)号：WO2011112779A3

公开(公告)日：2012-01-19

申请号：PCT/US2011027840

申请日：2011-03-10

Applicant: UNIV MISSOURI ,  SMITH MATTHEW J

Inventor： SMITH MATTHEW J

IPC: A61F2/30 ,  A61B17/86 ,  A61F2/46

CPC classification number: A61F2/4003 ,  A61B17/1637 ,  A61F2/30749 ,  A61F2/4081 ,  A61F2/4612 ,  A61F2002/30163 ,  A61F2002/30289 ,  A61F2002/30332 ,  A61F2002/30574 ,  A61F2002/30779 ,  A61F2002/3085 ,  A61F2002/4619 ,  A61F2002/4677

Abstract: Disclosed herein is a minimally invasive ball joint implant and prosthesis 10 for the treatment of arthritis, trauma, and other medical conditions leading to joint destruction and pain, as well as methods of use. In various cases, the prosthesis 10 does not require reaming into the intramedullary canal and does not require diaphyseal fit for any bones associated with the joint, thereby resulting in more rapid and complete recovery. In various cases, the prosthesis 10 incorporates an anchoring stem 38 specifically designed to be impacted into the bone and to facilitate bony ingrowth after implantation, thereby strengthening the implanted prosthesis 10 and preventing rotation thereof.

Abstract translation: 本文公开了一种用于治疗导致关节破坏和疼痛的关节炎，创伤和其他医学状况以及使用方法的微创球关节植入物和假体10。 在各种情况下，假体10不需要铰接到髓内管中，并且不需要对于与关节相关联的骨骼进行骨干合并，从而导致更快速和完全的恢复。 在各种情况下，假体10包括专门设计成撞击到骨中的锚固杆38，并且在植入之后便于骨向内生长，从而加强植入的假体10并防止其旋转。

公开(公告)号：WO2011097107A3

公开(公告)日：2011-12-01

申请号：PCT/US2011022673

申请日：2011-01-27

Applicant: UNIV MISSOURI ,  BARRIER BRETON F ,  CLARK GARY F

Inventor： BARRIER BRETON F ,  CLARK GARY F

IPC: A61B17/42 ,  A61M1/00

CPC classification number: A61B17/442

Abstract: In various embodiments, an obstetrical device 10 is provided for assisting a cesarean section delivery of a neonate having a fetal presenting part well seated within the mother's pelvis. Generally, the device 10 comprises a tubular tail 22 having an internal lumen 30 and a hollow head 26 extending from a distal end 58 of the tail 22 and having an internal chamber 34 fluidly connected to the lumen 30. The head 26 includes at least one aperture 38 extending through an exterior wall. The device 10 is operable to position the head 26 near or in contact with the fetal presenting part to provide air into an area near and/or between contact surfaces 62 of the fetal presenting part and a vagina 14 and/or a cervix 18 of the mother. Providing the air will reduce or release a suction formed between the contact surfaces 62 such that the well seated fetal presenting part can be easily separated from the vagina 14 and/or the cervix 18.

Abstract translation: 在各种实施例中，提供产科装置10用于辅助剖宫产输送新生儿，所述新生儿具有良好地坐在母亲骨盆内的胎儿呈现部分。 通常，装置10包括具有内腔30和从尾部22的远端58延伸并具有流体地连接到腔30的内室34的中空头部26的管状尾部22.头部26包括至少一个 孔38延伸穿过外壁。 装置10可操作以将头部26定位在胎儿呈现部分附近或与胎儿呈现部分接触，以将空气提供到胎儿呈现部分的接触表面62和胎儿呈现部分的阴道14和/或宫颈18附近和/或之间的区域 母亲。 提供空气将减少或释放在接触表面62之间形成的抽吸，使得安放好的胎儿先露部分能够容易地与阴道14和/或子宫颈18分离。