公开(公告)号：WO0229001A3

公开(公告)日：2003-08-21

申请号：PCT/US0130936

申请日：2001-10-03

Applicant: UNIV VIRGINIAN PATENT FOUNDATI ,  LYNCH KEVIN R ,  MACDONALD TIMOTHY L ,  HEISE CHRISTOPHER E ,  SANTOS WEBSTER L ,  OKUSA MARK D

Inventor： LYNCH KEVIN R ,  MACDONALD TIMOTHY L ,  HEISE CHRISTOPHER E ,  SANTOS WEBSTER L ,  OKUSA MARK D

IPC: C07F9/09 ,  C07F9/38 ,  C07F9/572 ,  C07F9/6506 ,  C07F9/655 ,  C07K14/705 ,  A61K31/16 ,  A61K31/04 ,  A61K31/075 ,  A61K31/08 ,  A61K31/13 ,  C07C211/00 ,  C07C233/00

CPC classification number: C07K14/705 ,  C07F9/091 ,  C07F9/094 ,  C07F9/3808 ,  C07F9/3873 ,  C07F9/3882 ,  C07F9/5728 ,  C07F9/65062 ,  C07F9/65515

Abstract: The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.

Abstract translation: 本发明涉及包含溶血磷脂酸类似物的组合物和使用这些类似物作为LPA受体活性的激动剂或拮抗剂的方法。 此外，本发明涉及在各个LPA受体（即LPA1，LPA2和LPA3）上的选择性程度变化的LPA受体激动剂。 更具体地说，本发明涉及LPA类似物，其中甘油被乙醇胺替代，并且多种取代已经在第二个碳原子连接。

公开(公告)号：WO02074925A3

公开(公告)日：2003-04-03

申请号：PCT/US0208402

申请日：2002-03-19

Applicant: UNIV VIRGINIAN PATENT FOUNDATI ,  OWENS GARY K ,  MANABE ICHIRO

Inventor： OWENS GARY K ,  MANABE ICHIRO

IPC: C12N5/077 ,  C12N15/00 ,  C12N15/63

CPC classification number: C12N5/0661 ,  C12N5/0662 ,  C12N2501/01 ,  C12N2501/385 ,  C12N2506/02 ,  C12N2510/00

Abstract: The present invention relates to purified smooth muscle progenitor cells and a method for isolating such cells. The purified smooth muscle progenitor cells of the present invention are capable of being induced into the smooth muscle cell lineage at high efficacy (i.e. greater than 60% conversion). The method comprises the steps of transforming cell populations that contain totipotent or pluripotent cells with DNA constructs that are expressed only in the smooth muscle cell lineage, inducing a portion of those cells and identifying those cells that express the construct only after the cells are induced.

Abstract translation: 本发明涉及纯化的平滑肌祖细胞和分离这些细胞的方法。 本发明的纯化的平滑肌祖细胞能够以高功效（即大于60％转化）被诱导成平滑肌细胞谱系。 该方法包括以下步骤：用仅在平滑肌细胞谱系中表达的DNA构建体转化含有全能或多能细胞的细胞群，诱导一部分细胞并鉴定仅在细胞诱导后才表达该构建体的那些细胞。