利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

185 条记录 (耗时 0.021 秒)

    A NEW AND IMPROVED PROCESS FOR THE PREPARATION OF IBANDRONATE SODIUM MONOHYDRATE
    4.
    发明申请
    A NEW AND IMPROVED PROCESS FOR THE PREPARATION OF IBANDRONATE SODIUM MONOHYDRATE 审中-公开
    用于制备IBANDRONATE SODIUM MONOHYDRATE的新改进方法

    公开(公告)号：WO2009093258A2

    公开(公告)日：2009-07-30

    申请号：PCT/IN2008000454

    申请日：2008-07-16

    申请人： FLEMING LAB LTD ,  BALASUBRAMANIAM RAVISHANKAR ,  POLSANI PULLA RAO ,  TAMMIREDDY GOWRI NAIDU

    发明人： BALASUBRAMANIAM RAVISHANKAR ,  POLSANI PULLA RAO ,  TAMMIREDDY GOWRI NAIDU

    IPC分类号： C07F9/38

    CPC分类号： C07F9/386 ,  C07F9/3873

    摘要： The present invention discloses a new and an improved process for preparation of Ibandronate sodium monohydrate. According to the process pentylamine is reacted with ethylacrylate to give N-pentyl-ß-alanine ethyl ester (XXIV), which on methylation provided N-methyl-N-pentyl-ß-alanine ethylester formula (XXV). The reresulting ester on hydrolysis and subsequent treatment with hydrochloric acid furnished 3-(N-methyl-N-pentylamino)propionic acid hydrochloride formula (II). Bisphosphorylation of 3-(N-methyl-N-pentylamino)propionic acid hydrochloride formula (II) with phosphorous acid and phosphorous trichloride followed by hydrolysis and subsequent treatment with a base provided Ibandronate monosodium monohydrate of formula (I).

    摘要翻译： 本发明公开了一种制备伊班膦酸钠一水合物的新方法和改进方法。 根据该方法，戊胺与丙烯酸乙酯反应得到N-戊基-β-丙氨酸乙酯（XXIV），其在甲基化时提供N-甲基-N-戊基-β-丙氨酸乙酯式（XXV）。 水解反应后的酯和随后用盐酸处理，得到3-（N-甲基-N-戊基氨基）丙酸盐酸盐配方（II）。 使用亚磷酸和三氯化磷将3-（N-甲基-N-戊基氨基）丙酸盐酸盐式（II）的二磷酸化反应水解，随后用碱处理，得到式（I）的I带膦酸单钠盐一水合物。

    CRYSTALLINE FORMS OF IBANDRONIC ACID AND PROCESSESES FOR THE PREPARATION THEREOF
    7.
    发明申请
    CRYSTALLINE FORMS OF IBANDRONIC ACID AND PROCESSESES FOR THE PREPARATION THEREOF 审中-公开
    IBANDRONIC酸的结晶形式及其制备方法

    公开(公告)号：WO2009042179A1

    公开(公告)日：2009-04-02

    申请号：PCT/US2008/011126

    申请日：2008-09-24

    申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. ,  TEVA PHARMACEUTICALS USA, INC. ,  SINGER, Claude ,  AVHAR-MAYDAN, Sharon ,  KOLTAI, Tamas ,  GOLD, Amir

    发明人： SINGER, Claude ,  AVHAR-MAYDAN, Sharon ,  KOLTAI, Tamas ,  GOLD, Amir

    IPC分类号： C07F9/38

    CPC分类号： C07F9/386 ,  C07F9/3873

    摘要： A crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about 4.1, 12.3 and 13.4 ± 0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 8.2, 11.3, 16.2 and 16.9 and 20.8 ± 0.2 degrees two-theta, and by a powder X-ray diffraction pattern depicted in Figure 1 is provided. Also provided is a crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about peaks at about 5.2, 11.7, and 18.7 ± 0.2 degrees two- theta and at least two more peaks selected from the group consisting of: 5.8, 10.1, 12.0, 17.1, and 20.0 ± 0.2 degrees two-theta and a powder X-ray diffraction pattern as depicted in Figure 2. Methods of preparing the crystalline forms are also provided.

    摘要翻译： 一种结晶伊班膦酸，其特征在于选自以下的数据：至少一种粉末X射线衍射图，其具有在约4.1,12.3和13.4±0.2度2-θ以及至少两个以上的峰，所述峰选自 ：8.2,11.3,16.2和16.9和20.8±0.2度2-θ，以及图1所示的粉末X射线衍射图。 还提供了结晶伊班膦酸，其特征在于选自以下的数据：粉末x射线衍射图案中的至少一种，其在约5.2,11.7和18.7±0.2度2θ处的峰处具有峰值，并且至少两个 更多选自5.8,10.1,12.0,17.1和20.0±0.2度2-θ的峰和如图2所示的粉末X射线衍射图。还提供了制备晶体形式的方法。

    POLYMER-LINKED-BISPHOSPHONATE INHALANT FORMULATIONS AND METHODS FOR USING THE SAME
    8.
    发明申请
    POLYMER-LINKED-BISPHOSPHONATE INHALANT FORMULATIONS AND METHODS FOR USING THE SAME 审中-公开
    聚合物连接的二磷酸盐助剂配方及其使用方法

    公开(公告)号：WO2008091337A1

    公开(公告)日：2008-07-31

    申请号：PCT/US2007/026427

    申请日：2007-12-27

    申请人： TEIKOKU PHARMA USA, INC. ,  KATSUMI, Hidemasa ,  YAMAMOTO, Akira ,  NAKATANI, Maria

    发明人： KATSUMI, Hidemasa ,  YAMAMOTO, Akira ,  NAKATANI, Maria

    IPC分类号： A61K31/67 ,  C07D327/00 ,  A61K31/74

    CPC分类号： C07F9/3873 ,  A61K31/67 ,  A61K31/74

    摘要： The present invention provides for methods of administering a bisphosphonate active agent to a subject in need thereof. Aspects of the invention include administering the bisphosphonate active agent to the subject by a pulmonary route, where the bisphosphonate active agent is bonded, either directly or through an intervening linking group, to a non-peptide polymer, such that the bisphosphonate active agent is a polymer-linked-bisphosphonate active agent. Also provided are compositions for use in practicing methods according to embodiments of the invention. Methods and compositions according to embodiments of the invention find use in a variety of different applications, including but not limited to, the treatment of bone adsorption disease conditions.

    摘要翻译： 本发明提供了向有需要的受试者施用双膦酸酯活性剂的方法。 本发明的方面包括通过肺途径将双膦酸盐活性剂施用于受试者，其中双膦酸酯活性剂直接或通过中间连接基团与非肽聚合物结合，使得双膦酸酯活性剂为 聚合物连接的双膦酸酯活性剂。 还提供了用于根据本发明的实施方案的实践方法中使用的组合物。 根据本发明的实施方案的方法和组合物可用于各种不同的应用，包括但不限于骨吸收疾病状况的治疗。

    PROCESS FOR MANUFACTURING BISPHOSPHONIC ACIDS
    10.
    发明申请
    PROCESS FOR MANUFACTURING BISPHOSPHONIC ACIDS 审中-公开
    制备双磷酸的方法

    公开(公告)号：WO2007109542A2

    公开(公告)日：2007-09-27

    申请号：PCT/US2007/064176

    申请日：2007-03-16

    申请人： ALBEMARLE CORPORATION ,  SAMSEL, Edward, G. ,  WU, Tse-chong

    发明人： SAMSEL, Edward, G. ,  WU, Tse-chong

    IPC分类号： C07F9/6506

    CPC分类号： C07F9/65061 ,  C07F9/386 ,  C07F9/3873 ,  C07F9/582 ,  C07F9/6561

    摘要： A manufacturing process for the preparation of bisphosphonic acids and in particular zoledronic acid is provided wherein diglyme, monoglyme, or a mixture thereof, is utilized to produce a homogenous, water soluble, solid reaction mass that upon cooling, dissolving in water and stripping results in a high purity product and comparatively good yield.

    摘要翻译： 提供了制备二膦酸，特别是唑来膦酸的制备方法，其中二甘醇二甲醚，单甘醇二甲醚或其混合物用于产生均匀的水溶性固体反应物质，其在冷却时溶解在水中并且汽提得到 高纯度的产品和较好的产量。