公开(公告)号：WO2022248517A1

公开(公告)日：2022-12-01

申请号：PCT/EP2022/064136

申请日：2022-05-24

Applicant: TOTALENERGIES ONETECH BELGIUM ,  UNIVERSITÉ DE RENNES 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： COUSTHAM, Thomas ,  CARPENTIER, Jean-François ,  KIRILLOV, Evgueni ,  THEODOSOPOULOU, Dimitra ,  WELLE, Alexandre ,  PIOLA, Lorenzo

IPC: C08F4/00 ,  C08F110/00 ,  C07F17/00

Abstract: The present invention relates to a catalyst of Formula (I) wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, L1, M1, Q1, and Q2 have the meaning defined in the description and claims. The present invention also relates to a catalyst composition comprising at least one catalyst according to the invention, an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to the use of a catalyst or catalyst composition according to the invention for the preparation of an olefin polymer. The present invention also relates to an olefin polymerization process, the process comprising: contacting a catalyst or a catalyst composition according to the invention, with an olefin monomer, optionally hydrogen, and optionally one or more olefin comonomers; polymerizing the monomer, and the optionally one or more olefin comonomers, in the presence of the at least one catalyst composition, and optional hydrogen, thereby obtaining an olefin polymer. The present invention also relates to olefin polymers and articles comprising said olefin polymer.

公开(公告)号：WO2022223488A1

公开(公告)日：2022-10-27

申请号：PCT/EP2022/060187

申请日：2022-04-15

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ETABLISSEMENT FRANÇAIS DU SANG (EFS) ,  UNIVERSITÉ DE LIMOGES ,  UNIVERSITÉ DE MONTPELLIER ,  UNIVERSITÉ DE RENNES 1

Inventor： FEST, Thierry ,  DELPY, Laurent ,  HAAS, Marion ,  MARCHALOT, Anne ,  LACOMBE, Gersende ,  MOREAUX, Jérôme

IPC: C12N15/113

Abstract: PIM2 kinase deregulation has been reported in several cancers. In particular, PIM2 is considered in multiple myeloma as part of the oncogenic process and several PIM kinase inhibitors have been developed showing encouraging results in preclinical studies and clinical trials. Now the inventors have developed an antisense RNA strategy based on a splice-switching oligonucleotide (SSO) so as to induce efficient knockdown of PIM2 expression. This SSO-mediated knockdown is a powerful approach to for cancer treatments. Accordingly, the present invention relates to the use of splice switching oligonucleotides for exon skipping-mediated knockdown of PIM2.

公开(公告)号：WO2022013112A1

公开(公告)日：2022-01-20

申请号：PCT/EP2021/069232

申请日：2021-07-09

Applicant: COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITÉ PARIS-SACLAY ,  UNIVERSITÉ DE RENNES 1 ,  ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE RENNES ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES

Inventor： PIETERS, Grégory ,  FAVEREAU, Ludovic ,  POULARD, Laurelie ,  COEHLO, Max ,  FREDERIC, Lucas ,  KASEMTHAVEECHOK, Sitthichok ,  CRASSOUS, Jeanne

IPC: C07D491/22 ,  H01L51/50

Abstract: La présente invention concerne des composés possédant à la fois les propriétés de fluorescence retardée activée thermiquement (TADF), d'émission de la lumière circulairement polarisée (CPL) et de regain de fluorescence par agrégation (AIEE). L'invention concerne également l'utilisation de tels composés en tant que photocatalyseur ou en tant que dopant notamment dans les couches émettrices de diodes électroluminescentes (OLEDs), ainsi que les dispositifs électroluminescents ou les diodes électroluminescentes (OLEDs) comprenant de tels composés.

公开(公告)号：WO2021175796A1

公开(公告)日：2021-09-10

申请号：PCT/EP2021/055080

申请日：2021-03-01

Applicant: CENTRALESUPELEC ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE NATIONALE SUPERIEURE DE CHIMIE DE RENNES ,  INSTITUT NATIONAL DES SCIENCES APPLIQUÉES DE RENNES (INSA) ,  UNIVERSITE DE BRETAGNE OCCIDENTALE ,  UNIVERSITÉ DE RENNES 1 ,  UNIVERSITE DE NANTES

Inventor： DENIS, Antoine ,  RONDEAU, David ,  HIMDI, Mohamed ,  CASTEL, Xavier ,  CORDIER, Stéphane

IPC: G01N22/00 ,  G01N33/00

Abstract: L'invention se rapporte à un capteur pour la détection de composé volatile ou de gaz, comprenant un transducteur comprenant : - un résonateur plan comprenant une pluralité de pistes métalliques, sur circuit imprimé, de type coplanaire; - une couche sensible déposée sur une portion prédéterminée dudit résonateur, ladite couche sensible étant configurée de sorte qu'une présence d'un composé volatile ou d'un gaz à détecter implique une modification de la permittivité de la couche sensible entrainant une modification de caractéristiques dudit capteur lors de son alimentation électrique.

公开(公告)号：WO2020239961A1

公开(公告)日：2020-12-03

申请号：PCT/EP2020/064930

申请日：2020-05-28

Applicant: UNIVERSITÉ DE RENNES 1 ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

Inventor： HUAULMÉ, Arnaud ,  DESPINOY, Fabien ,  JANNIN, Pierre ,  HARADA, Kanako ,  MITSUISHI, Mamoru

IPC: G16H70/20

Abstract: A method for generation a surgical process model as a temporal sequence of semantic data describing a surgical process at a semantic level. The method comprises obtaining from the simulator (1000) at least one temporal sequence of digital data (1001) describing at a physical level the virtual surgical process simulated by the simulator in a virtual space, wherein the digital data comprise interaction data representing interactions between objects in the virtual space and kinematic data related to object displacements in the virtual space; automatically converting (1010, 1020, 1040, 1060), based on at least one configuration file (1002), said at least one temporal sequence of digital data into said temporal sequence of semantic data. The configuration file (1002) comprises semantic data representative of one or more surgical process activities and a set of one or more activity detection rules respectively associated with one or more surgical process activities defined by the semantic data.

公开(公告)号：WO2019149911A1

公开(公告)日：2019-08-08

申请号：PCT/EP2019/052549

申请日：2019-02-01

Applicant: UNIVERSITÉ DE RENNES 1 ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Inventor： HASSAN, Mahmoud ,  WENDLING, Fabrice ,  KABBARA, Aya

IPC: G16H50/20 ,  G16H20/40 ,  A61B5/00

CPC classification number: G16H20/40 ,  A61B5/4094 ,  G16H50/20 ,  G16H50/30

Abstract: The invention relates to a method of constructing a value representative of an interaction between a plurality of brain networks, the method being implemented by an electronic device, said electronic device comprising a processor and a memory. According to the invention, the method comprises: obtaining (10), in the form of connectivity matrices, dynamic functional networks, which are representative of electrical signals measured for a predetermined number of points of interest, called nodes, within a cerebral cortex during a given time period; grouping (20) of the nodes, as a function of topological properties of said networks, within groups of nodes called modules; calculating (30) the index representing local epileptogenic network as a function of local functional connectivity characteristics of said nodes, modules and networks.

公开(公告)号：WO2019106243A1

公开(公告)日：2019-06-06

申请号：PCT/FR2018/052011

申请日：2018-08-03

Applicant: LE FLOCH,, Albert ,  UNIVERSITÉ DE RENNES 1

Inventor： LE FLOCH,, Albert ,  ROPARS, Guy

IPC: G02B27/02 ,  G02B27/22 ,  G03B9/08 ,  G03B9/58 ,  G02B27/26 ,  G02C1/00 ,  G02C7/10 ,  A61B5/16 ,  A61F9/02

Abstract: L'invention concerne un dispositif optique de filtrage (FILT) de la lumière reçue, par polarisation ou mécaniquement, depuis un support présentant un contenu graphique et/ou textuel, caractérisé en ce des cycles d'ouverture et de fermeture d'un espace de vision, dans un spectre de lumière visible,sont opérés périodiquement à partir du dispositif optique(FILT) à une fréquence Fd prédéterminée et en ce que les périodes d'ouverture successives ont chacune une durée (T1) comprise dans un intervalle de valeurs allant de 15 à 35%de la durée (T) des cycles opérés.

公开(公告)号：WO2018206644A1

公开(公告)日：2018-11-15

申请号：PCT/EP2018/062006

申请日：2018-05-09

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE RENNES 1 ,  CENTRE EUGENE MARQUIS ,  ENIOS APPLICATIONS PRIVATE LIMITED COMPANY

Inventor： CHEVET, Eric ,  AVRIL, Tony ,  CHATZIIOANNOU, Aristotelis

IPC: G01N33/574

Abstract: The present invention relates to method of therapy selection for patient suffering from glioblastoma. Using in vitro and in vivo approaches, the inventors demonstrated the critical role of CD90 in GBM migration/invasion. They showed that CD90 signaling though SRC, FAK and RhoA promotes cell migration and importantly, that high CD90 expression impacts on the cell response to the SRC inhibitor dasatinib. In particular, the present invention relates to a method for predicting whether a subject will be eligible to a treatment with a drug selected from the group consisting of SRC inhibitor, FAK inhibitor or RhoA inhibitor by determining the expression level of CD90 in a sample obtained from the subject.

公开(公告)号：WO2018189215A1

公开(公告)日：2018-10-18

申请号：PCT/EP2018/059229

申请日：2018-04-11

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE RENNES 1 ,  THE UNIVERSITY OF QUEENSLAND

Inventor： MUSSO, Orlando ,  ROHART, Florian ,  LE CAO, Kim-Anh ,  DESERT, Romain

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The invention relates to the prediction of the outcome of a patient suffering from HCC. This study was conducted to determine whether non-proliferative HCCs carrying wild-type CTNNB1 warrant consideration as a distinct, clinically relevant tumor subclass. The inventors constructed an 1133-HCC transcriptomic metadata set and identified four HCC subclasses by discriminant analyses and hierarchical clustering. They developed a method to predict CTNNB1 mutations in an independent set of 225 β-catenin-sequenced HCCs and validated HCC classification, CTNNB1 mutation prediction and survival analyses in an independent 210-HCC full-genome sequenced RNAseq dataset. Altogether, analysis of data from 1568 HCC patients identified two new well-differentiated, low-proliferation subclasses of HCCs. Both subclasses (periportal-type and perivenous-type) showed favorable outcomes. Periportal-type HCCs showed the highest 2-year recurrence-free survival rates by multivariate analysis, suggesting that these tumors have the lowest potential for early recurrence among all HCCs. Thus, the invention relates to a method for predicting the survival time of a patient suffering from HCC comprising determining the expression level of the genes elected in the group consisting in AGXT, FETUB, GLS2, GNMT, SLC10A1 and SLC22A7.

公开(公告)号：WO2015124802A1

公开(公告)日：2015-08-27

申请号：PCT/EP2015/053859

申请日：2015-02-24

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITÉ AIX-MARSEILLE ,  UNIVERSITÉ DE RENNES 1

Inventor： ACKERMANN, Jörg ,  MARGEAT, Olivier ,  HISSLER, Muriel ,  BOUIT, Pierre Antoine

IPC: C09K11/02 ,  C09K11/54 ,  H05B33/14 ,  H01L51/00

CPC classification number: C09K11/02 ,  B82Y20/00 ,  B82Y40/00 ,  C07F9/65685 ,  C09K11/025 ,  C09K11/06 ,  C09K11/54 ,  C09K2211/1007 ,  C09K2211/1096 ,  H01L51/00 ,  H01L51/0071 ,  H01L51/441 ,  H01L51/5004 ,  H01L51/502 ,  H01L2251/305 ,  H01L2251/552 ,  H05B33/14 ,  Y10S977/774 ,  Y10S977/89 ,  Y10S977/95

Abstract: A luminescent hybrid nanomaterial comprising: at least one inorganic nanomaterial comprising an inorganic first compound; and at least one second compound comprising a first aggregation-induced emission moiety, wherein the at least one second compound is grafted on at least part of a surface of the inorganic first compound.

Abstract translation: 一种发光混合纳米材料，包括：至少一种包含无机第一化合物的无机纳米材料; 和至少一种包含第一聚集诱发的发射部分的第二化合物，其中所述至少一种第二化合物接枝在所述无机第一化合物的表面的至少一部分上。