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公开(公告)号：WO2021239931A1
公开(公告)日：2021-12-02
申请号：PCT/EP2021/064317
申请日：2021-05-28
Inventor： OEVERING, Hendrik , GELISSEN, Franciscus, Wilhelmus, Maria , THIES, Jens, Christoph , EMANS, Pieter , ROTH, Alex, Kristian
Abstract: The invention concerns a polymer composition for making a bone anchoring part of an orthopedic implant for use in repair of damaged cartilage tissue, comprising a biostable thermoplastic polyurethane and 15-70 mass% of micron-sized inorganic particles comprising a biocompatible transition metal compound. It was found that the relatively rigid TPU composition comprising said inorganic particles allows making an anchoring part that can be inserted or press-fitted into a pre-drilled bone hole to form a firm and durable connection to bone tissue, and which may be visualized with for example X-ray or MRI methods. The polymer composition shows favorable properties and enables freedom in designing and making the implant with common techniques like injection molding. In other aspects, the invention relates to methods of making said polymer composition, and to using the polymer composition in making an orthopedic implant comprising a bone anchoring part, like in forming the implant with a multi-component injection molding process comprising a step of molding the bone anchoring part from the polymer composition.
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公开(公告)号：WO2019170790A1
公开(公告)日：2019-09-12
申请号：PCT/EP2019/055631
申请日：2019-03-07
Applicant: DSM IP ASSETS B.V. , UNIVERSITY MAASTRICHT
IPC: A61K31/716 , A23L29/00 , A23L29/212 , A61P3/04
Abstract: The present invention relates to yeast beta glucans for increasing the acetate concentration in the distal colon of a patient. According to another aspect, the present invention relates to yeast beta glucans for use in a method of treating or preventing a condition selected from overweight and obesity in a human or animal patient in need thereof. According to yet another aspect, the present invention relates to an alimentary product, or a food supplement, comprising yeast beta glucan and/or starch. According to another aspect the present invention relates to a method for increasing the acetate concentration in the distal colon of a patient.
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公开(公告)号：WO2021239932A1
公开(公告)日：2021-12-02
申请号：PCT/EP2021/064318
申请日：2021-05-28
Applicant: DSM IP ASSETS B.V. , MAASTRICHT UNIVERSITAIR MEDISCH CENTRUM+ , TECHNISCHE UNIVERSITEIT EINDHOVEN , UNIVERSITY MAASTRICHT
Inventor： OEVERING, Hendrik , GELISSEN, Franciscus, Wilhelmus, Maria , THIES, Jens, Christoph , EMANS, Pieter , ROTH, Alex, Kristian , VAN DONKELAAR, Corrinus, Cornelis , ASIK, Emin, Erkan
Abstract: Present invention relates to an orthopedic implant having a bone anchoring part comprising a polymer composition comprising a biostable thermoplastic polyurethane (TPU) and 15-70 mass% of inorganic particles comprising zirconia. It was found that this relatively rigid anchoring part allows inserting an implant into a pre-drilled bone hole to form a firm and durable connection to bone, which may be visualized with for example X-ray or MRI methods. The thermoplastic polyurethane composition shows favorable properties, and offers freedom in design and dimensioning of the implant, and in making the implant with common techniques like injection molding. Especially if the implant comprises a cartilage replacing part made from a resilient thermoplastic material compatible with the polyurethane-zirconia composition, like a more flexible TPU composition, the implant may be made with a 2-component injection molding technique. In other aspects, the invention relates to a method of making said orthopedic implant comprising a bone anchoring part with a multi-component injection molding process. The invention further relates to a surgical kit of parts comprising orthopedic implants of the invention, and to the use of an implant or a surgical kit of the invention in orthopedic surgery.
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