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    BACTERIAL MICROCOMPARTMENTAL SHELLS
    1.
    发明申请
    BACTERIAL MICROCOMPARTMENTAL SHELLS 审中-公开

    公开(公告)号：WO2022074380A1

    公开(公告)日：2022-04-14

    申请号：PCT/GB2021/052574

    申请日：2021-10-05

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： LIU, Luning ,  LI, Tianpei ,  JIANG, Qiuyao ,  HUANG, Fang

    IPC: C12N1/20 ,  C07K17/02 ,  C12N15/82

    Abstract: The present invention relates to new synthetically generated carboxysome shells, shells encapsulating selected catalytically active enzymes, cells including the shells and methods of making the shells and methods of encapsulation. The invention also includes uses of the cells as nanoreactors for enhanced catalytic performance of the encapsulated enzymes and the use of an encapsulation protein for recruiting external cargo proteins into a synthetic carboxysome shell.

    PLASMA CONVERSION REACTOR OF C02 WITH C1 TO C4 HYDROCARBON TO C1 TO C5 OXYGENATE AND METHOD THEREOF
    2.
    发明申请
    PLASMA CONVERSION REACTOR OF C02 WITH C1 TO C4 HYDROCARBON TO C1 TO C5 OXYGENATE AND METHOD THEREOF 审中-公开

    公开(公告)号：WO2021255423A1

    公开(公告)日：2021-12-23

    申请号：PCT/GB2021/051481

    申请日：2021-06-15

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： TU, Xin ,  WANG, Yaolin

    IPC: B01J19/08 ,  C07C2/00 ,  B01J19/088 ,  B01J2219/0896 ,  C07C29/15 ,  C07C45/28 ,  C07C51/15

    Abstract: An apparatus for forming a C1 to C5 oxygenate from carbon dioxide and a C1 to C4 hydrocarbon is described. The apparatus comprises: a dielectric barrier discharge, DBD, device arranged to generate a plasma; and a passageway having an inlet for the carbon dioxide and the C1 to C4 hydrocarbon and an outlet for the oxygenates. In one example the passageway includes therein a catalyst. The passageway extends, at least in part, through the DBD device wherein, in use, the carbon dioxide in reacted with the C1 to C4 hydrocarbon in the generated plasma, thereby forming the oxygenates from at least some of the carbon dioxide and the C1 to C4 hydrocarbon. The DBD device comprises a conducting liquid as a ground electrode. A method and a use are also described.

    BONE MARROW MESENCHYMAL STEM CELL DERIVED CELL POPULATIONS AND METHODS OF PREPARING SAME
    5.
    发明申请
    BONE MARROW MESENCHYMAL STEM CELL DERIVED CELL POPULATIONS AND METHODS OF PREPARING SAME 审中-公开

    公开(公告)号：WO2021064424A1

    公开(公告)日：2021-04-08

    申请号：PCT/GB2020/052439

    申请日：2020-10-02

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： HOLLANDER, Anthony Peter

    IPC: C12N5/0775 ,  A61K35/28

    Abstract: Provided are populations of cells enriched for MSC-derived cells that are: CD90+; CD105+; CD45-; as well as TIMP-1 secretion high, and MMP13 gene expression low. Such populations of cells are useful as medicaments in contexts where it is desired to make use of the trophic or immunosuppressive therapeutic effects of MSCs, but to avoid activity associated with the capacity of MSCs to undergo phenotypic differentiation. Populations of cells of the invention are useful in the treatment of a condition selected from the group consisting of: osteoarthritis; myocardial infarction; meniscus cartilage injury (such as torn meniscus); ligament injury (such as torn ligament); injuries to the skin; and soft tissue injury. They may also be used in treatment of a disease selected from the group consisting of: haematological disease; graft- versus-host disease; and inflammatory disease.

    METHOD FOR DETECTING THE PRESENCE OF ONE OR MORE BACTERIAL TOXINS IN A BIOLOGICAL FLUID USING LIPOSOMES
    8.
    发明申请
    METHOD FOR DETECTING THE PRESENCE OF ONE OR MORE BACTERIAL TOXINS IN A BIOLOGICAL FLUID USING LIPOSOMES 审中-公开

    公开(公告)号：WO2018206961A1

    公开(公告)日：2018-11-15

    申请号：PCT/GB2018/051261

    申请日：2018-05-10

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： KADIOGLU, Aras ,  NEILL, Daniel ,  PANAGIOTOU, Stavros

    IPC: G01N33/50 ,  G01N33/543 ,  G01N33/569

    Abstract: The present invention relates to a method for detecting the presence of one or more bacterial toxins, capable of binding to cell membranes, in biological fluid wherein the method comprises: (i) incubating the biological fluid with a plurality of liposomes, wherein the liposomes comprise a lipid capable of binding to said one or more toxins, to provide one or more liposome-toxin conjugate; (ii) incubating said conjugates with at least one type of antibody bound to a label to provide one or more conjugate-antibody complex; wherein each type of antibody in the mixture is specific for one of the bacterial toxins whose presence is to be detected; and (iii) analysing said complexes in order to detect the presence of one or more bacterial toxins capable of binding to cell membranes. Further aspects of the invention relate to a conjugate-antibody complex useful in the methods of the invention and a kit useful for performing the method of the invention.

    BRANCHED POLYMERS
    9.
    发明申请
    BRANCHED POLYMERS 审中-公开

    公开(公告)号：WO2018197885A1

    公开(公告)日：2018-11-01

    申请号：PCT/GB2018/051106

    申请日：2018-04-26

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： RANNARD, Steve ,  CHAMBON, Pierre ,  CASSIN, Savannah

    IPC: C08F2/38

    Abstract: A method of preparing a branched polymer comprises the free radical polymerisation of a multivinyl monomer in the presence of a chain transfer agent, using a source of radicals, wherein the extent of propagation is controlled relative to the extent of chain transfer to prevent gelation of the polymer. The average length of each vinyl polymer chain within the product is short.

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