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    ORGAN FUNCTION REPLACEMENT COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    1.
    发明申请
    ORGAN FUNCTION REPLACEMENT COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
    组织功能替代组合物及其制备和使用方法

    公开(公告)号：WO1996039490A1

    公开(公告)日：1996-12-12

    申请号：PCT/US1996009431

    申请日：1996-06-06

    申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, by and on behalf of THE UNIVERSITY OF NEBRASKA MEDICAL CENTER

    发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, by and on behalf of THE UNIVERSITY OF NEBRASKA MEDICAL CENTER ,  WEINER, David, B. ,  FOX, Ira, J.

    IPC分类号： C12N05/16

    CPC分类号： C07K14/54 ,  A61K48/00

    摘要： Recombinant cells are disclosed. The cells comprise a recombinant expression cassette which contains a nucleotide sequence that encodes a condition sensitive transforming protein operable linked to an activatable regulatory element. The cells additionally comprise a gene that encodes a protein which can be targeted for selective elimination. Methods of treating an individual suspected of suffering from an organ insufficiency condition are disclosed. The methods comprise introducing into such an individual, a plurality of recombinant cells that comprise a recombinant expression cassette which contains a nucleotide sequence that encodes a condition sensitive transforming protein operable linked to an activatable regulatory element and that also comprise a gene that encodes a protein which can be targeted for selective elimination. Implantable devices are disclosed. The implantable devices comprise a plurality of recombinant cells that comprise a recombinant expression cassette which contains a nucleotide sequence that encodes a condition sensitive transforming protein operable linked to an activatable regulatory element and that also comprise a gene that encodes a protein which can be targeted for selective elimination. Gene therapy compositions and methods are disclosed for preparing and using recombinant cells to deliver therapeutic proteins to individuals.

    摘要翻译： 公开了重组细胞。 细胞包含重组表达盒，其包含编码可操作地连接到可激活调节元件的条件敏感性转化蛋白的核苷酸序列。 细胞另外包含编码可靶向用于选择性消除的蛋白质的基因。 公开了治疗怀疑患有器官功能不全状况的个体的方法。 所述方法包括向这样的个体中引入包含重组表达盒的多个重组细胞，所述重组表达盒含有编码与可活化调节元件相连的条件敏感型转化蛋白的核苷酸序列，并且还包含编码蛋白质的基因 可以针对选择性消除。 公开了可植入装置。 可植入装置包括多个重组细胞，其包含重组表达盒，所述重组表达盒含有编码可操作地连接于可激活调节元件的条件敏感型转化蛋白的核苷酸序列，并且还包含编码可靶向选择性蛋白质的基因 淘汰。 公开了用于制备和使用重组细胞向个体递送治疗性蛋白质的基因治疗组合物和方法。

    SUPPRESSION OF COVID-19 REPLICATION BY COVID-19 ENTRY INHIBITORS
    4.
    发明申请
    SUPPRESSION OF COVID-19 REPLICATION BY COVID-19 ENTRY INHIBITORS 审中-公开

    公开(公告)号：WO2022187521A1

    公开(公告)日：2022-09-09

    申请号：PCT/US2022/018749

    申请日：2022-03-03

    申请人： THE CURATORS OF THE UNIVERSITY OF MISSOURI ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

    发明人： SINGH, Kamlendra ,  BYRAREDDY, Siddappa ,  ACHARYA, Arpan

    IPC分类号： A61K39/215 ,  C12N7/00 ,  C12N15/86

    摘要： The present invention relates to compounds, compositions, and methods, for treating viral infections. In particular, entry inhibitor compounds are disclosed for treatment of coronavirus infections, including SARS-CoV-1 and SARS-CoV-2 infections. The compounds bind to the interface of a SARS-CoV-2 spike protein receptor binding domain (RBD) and a host cell ACE-2 receptor. The entry inhibitor compounds show antiviral activity, favorable kinetics, and temporally act at the entry of SARS-CoV-2 infection. In embodiments, the compounds are used as medicaments for the inhibition of viral replication including SARS-CoV-1 and/or SARS-CoV-2 replication, for the treatment or prophylaxis of viral infections including SARS-CoV-1 and SARS-CoV-2 infections, and/or for the treatment or prophylaxis of an illness due to SARS-CoV-1 and SARS-CoV-2 infections.

    MEDICAL DEVICE DIAGNOSTICS AND ALERTING
    8.
    发明申请
    MEDICAL DEVICE DIAGNOSTICS AND ALERTING 审中-公开

    公开(公告)号：WO2022046268A1

    公开(公告)日：2022-03-03

    申请号：PCT/US2021/038805

    申请日：2021-06-24

    申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

    发明人： REDWOOD, William, Owen ,  DUNN, Jeff ,  HESTER, Riley ,  TRENT, Ian ,  WRIGHT, Eric ,  MILLER, Brad ,  TAUIL, Orly

    IPC分类号： A61B5/276 ,  G01R31/00 ,  G01R31/28

    摘要： Methods and systems for medical device diagnostics and reporting. One system including an electronic processor configured to receive a new medical device dataset associated with a medical device. The electronic processor is also configured to determine an operation classification of the medical device using a model utilizing training information. The training information includes a plurality of archived medical device datasets and an associated operation classification for each of the plurality of archived medical device datasets. The electronic processor is also configured determine an operation status of the medical device based on the operation classification. The electronic processor is also configured to generate and provide a notification based on at least the operation status of the medical device.