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公开(公告)号：WO2023039405A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/076022
申请日：2022-09-07
发明人： VAN NGUYEN, Thang
IPC分类号： A61K31/4412 , A61K31/4015 , G01N33/574 , A61K45/00 , A61P35/00 , A61P43/00
摘要： The present disclosure is generally directed to compositions and methods related to USP15 inhibitors. More particularly, the present disclosure relates to methods of regulating CRL4CRBN-USP15 pathway (previously referred to as the CRL4CRBN-p97 pathway) and glutamine synthetase levels and methods of treating diseases such as cancer via administration of USP15 inhibitors.
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公开(公告)号：WO2023018818A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/039982
申请日：2022-08-10
发明人： MIDHA, Ashok , LODAGALA, Vamsi , PRASANNA, Pratheek Bagivalu , BUSCHKOETTER, Kyle , KOMATIREDDY, Jyothi , BAPAT, Sushrut G.
IPC分类号： A63B21/05 , A63B21/02 , A63B21/00 , A63B23/16 , A63B23/035
摘要： A variable resistance device includes first and second body elements and a force¬ generating system disposed therebetween. The force-generating system includes a resiliently deflectable beam extending relative to the first body element and toward the second body element, an interface element, and a cam projecting relative to the second body element and toward the first body element. The cam presents a cam surface. The interface element shifts along the cam surface upon application of a driving force to at least one of the body elements relative to the other and consequent shifting of the body elements relative to each other, resulting in corresponding bending of the beam and consequent generation of a resistance force by the beam. The cam surface presents a profile that varies along a length thereof, such that the resistance force generated by the beam varies irregularly as the interface element moves along the cam surface.
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公开(公告)号：WO2022241008A2
公开(公告)日：2022-11-17
申请号：PCT/US2022/028799
申请日：2022-05-11
摘要： The disclosure relates to CYP72A polypeptides that mediate resistance to insect pests in plants. Also disclosed are plants comprising polynucleotides encoding the CYP72A polypeptides along with related methods of using polynucleotides that encode the CYP72A polypeptides to confer resistance to feeding by insect pests.
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公开(公告)号：WO2022182532A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/016066
申请日：2022-02-11
发明人： COYLE, Damon
摘要： A neonate intravenous (IV) training module for practicing critical nursing skills, wherein the training module comprises an inner core structured to have the size and shape of a neonate appendage, the inner core comprising at least one shallow blood vessel channel formed therein. The training module additionally comprises a removable outer skin glove structured to have the size and appearance of a neonate appendage, the outer skin glove being removably disposable over at least a portion the inner core. The training module further comprises at least one flexible blood vessel tubing that is removably disposable within the at least one blood vessel channel, and the at least one flexible tubing structure to have an outer diameter and wall thickness of a neonate blood vessel.
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公开(公告)号：WO2022046687A1
公开(公告)日：2022-03-03
申请号：PCT/US2021/047234
申请日：2021-08-24
发明人： CHEN, Genda , GAO, Jie , GUO, Chuanrui
摘要： A miniature, micrometer-accuracy, three-dimensional (3D) position-to-optical displacement sensor that has at least one extrinsic Fabry-Perot interferometer (EFPI) in Z direction and a series of plasmonic metasurface resonators with distinctive wavelength-selective characteristics in X and Y directions. The interferometer comprises at least one single mode optic fiber for light propagation, and a substrate mirror to create a light interference fringe as a function of distance between the mirror and the distal end of the optic fiber. Each plasmonic resonator is capable of modifying the substrate mirror and comprises an array of multiple unit nanostructure unit cells that are arranged in a two-dimensional (2D) square lattice or array in the X - Y plane. The nanostructure unit cells are preferably inscribed in the top layer of a three-layer thin film via the focused ion beam (FIB).
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公开(公告)号：WO2021247965A2
公开(公告)日：2021-12-09
申请号：PCT/US2021/035849
申请日：2021-06-04
发明人： SUN, Hongmin , ZOU, Xiaoqin , HENG, Xiao , XU, Xianjin , JI, Juan
摘要： Disclosed herein are new peptide inhibitors against beta-lactam resistance that can improve the efficacy of currently available antibiotics. Methods of using the peptide inhibitors for treating bacterial infections are also disclosed.
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公开(公告)号：WO2021216648A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028313
申请日：2021-04-21
发明人： MA, Hongbin
IPC分类号： A47J41/00
摘要： A heat loss protection lid for a thermal liquid container system, wherein the heat loss protection lid comprises a central body, a liquid ingress opening formed within the central body, a liquid dispensing opening formed within one of a peripheral edge of the central body or a lip formed around the peripheral edge of the central body and a concealed air intake hole.
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公开(公告)号：WO2021030559A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/046128
申请日：2020-08-13
摘要： Methods for disaggregating nanodiamond clusters, for example, by using sonication to break apart nanodiamond aggregates in an aqueous slurry having an alkaline pH. Compositions, such as aqueous nanodiamond dispersions and dry particulate compositions can be produced using these methods.
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公开(公告)号：WO2020251710A2
公开(公告)日：2020-12-17
申请号：PCT/US2020/032299
申请日：2020-05-11
发明人： LIANG, Xinhua , YU, Han
IPC分类号： H01M4/28
摘要： Improving the performance of cathodes by using surface coatings has proven to be an effective method for improving the stability of Li-ion batteries (LIBs), while a high-quality film satisfying all requirements of electrochemical inertia, chemical stability, and lithium ion conductivity has not been found. In this study, a composite film composed of Al 2 O 3 and AlF 3 layers was coated on the surface of Li 1.2 Mn 0.54 Co 0.13 Ni 0.13 O 2 (Li-rich NMC) based electrodes by atomic layer deposition (ALD). By varying the ratio of AI 2 O 3 and AIF 3 , an optimal coating was achieved. The electrochemical characterization results indicated that the coating with 1 cycle of AIF 3 ALD on 5 cycles of AI 2 O 3 ALD (IAIF 3 -5AI 2 O 3 ) significantly improved the cycling stability and alleviated the voltage attenuation problem of Li-rich NMC based electrodes by suppressing side reactions between the electrolyte and electrode, as well as inhibiting the transformation of layered Li 2 MnO 3 into a spinel-like phase. After 200 cycles of charge-discharge, the discharge capacity retention of LIB half cells based on 1AIF 3 -5AI 2 O 3 coated Li-rich NMC electrodes kept at 84%, much higher than that of the uncoated Li-rich NMC (the capacity retention less than 20%).
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10.发明申请
公开(公告)号：WO2020047369A2
公开(公告)日：2020-03-05
申请号：PCT/US2019/048986
申请日：2019-08-30
发明人： HAN, Xu , KOULEN, Peter , CRITSER, John, K.
IPC分类号： H04B1/10
摘要： A cryoprotective device protects an aqueous biological material from mechanical damage due to ice formation during cryogenic freezing and/or cryostorage by preventing direct contact of the biological material with cell- damaging large ice crystals, the cryoprotective storage device having a housing with an internal cavity. The housing is configured to receive a freezable medium with the biological material within the internal cavity. The housing includes a semi-permeable membrane. The membrane is impermeable to ice crystals that are larger than an average pore size of the membrane to prevent such ice crystals from passing into the internal cavity from outside the housing, such that ice crystals formed in the medium within the housing have a smaller crystal size from ice crystals formed in the medium outside of the housing. As such, the biological material is protected from mechanical damage generated by direct contact with large ice crystals.
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