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    A METHOD OF ISOLATING EXOSOMES
    2.
    发明申请
    A METHOD OF ISOLATING EXOSOMES 审中-公开

    公开(公告)号：WO2021110920A1

    公开(公告)日：2021-06-10

    申请号：PCT/EP2020/084640

    申请日：2020-12-04

    Applicant: UNIVERSITY OF ULSTER

    Inventor： DUGUEZ, Stephanie ,  DUDDY, William ,  CONNOLLY, Owen

    IPC: C12N5/077 ,  C07K14/78 ,  C07K16/28 ,  A61K35/16 ,  A61K35/34 ,  G01N33/543 ,  G01N33/50

    Abstract: The present invention relates to a method of isolating exosomes. Specifically, the invention relates to a method comprising the steps of providing a sample including exosomes; identifying a cell-surface polypeptide on the exosomes; and isolating the exosomes using the cell-surface polypeptide on the exosomes. The exosomes isolated from by the methods of the invention can be studied for the purposes of biomarker identification, for the understanding of biological function and disease, and to find ways to target them with therapeutics.

    CALCIUM PEROXIDES NANOPARTICLES AS ADJUVANT THERAPY
    4.
    发明申请
    CALCIUM PEROXIDES NANOPARTICLES AS ADJUVANT THERAPY 审中-公开

    公开(公告)号：WO2018203083A3

    公开(公告)日：2018-11-08

    申请号：PCT/GB2018/051207

    申请日：2018-05-04

    Applicant: UNIVERSITY OF ULSTER

    Inventor： MCHALE, Anthony ,  CALLAN, John ,  SHENG, Yingjie

    IPC: A61K41/00 ,  A61K9/51 ,  A61K47/02

    Abstract: The invention provides CaO 2 nanoparticles having a p H-responsive coating for use in a method of adjuvant therapy of hypoxic tumour cells or tissues. The nanoparticles find particular use in enhancing cancer therapies that depend on oxygen to exert their effect, such as photodynamic therapy (PDT), sonodynamic therapy (SDT), and radiotherapy. The invention also provides pharmaceutical compositions containing the coated CaO 2 nanoparticles, together with at least one photosensitiser, sonosensitiser, or radiosensitiser and, optionally, at least one pharmaceutical carrier or excipient.

    METHOD AND APPARATUS FOR FORMING A COMPOUND CURVATURE METAL SKIN
    7.
    发明申请
    METHOD AND APPARATUS FOR FORMING A COMPOUND CURVATURE METAL SKIN 审中-公开
    用于形成化合物弯曲金属皮肤的方法和装置

    公开(公告)号：WO2016156094A1

    公开(公告)日：2016-10-06

    申请号：PCT/EP2016/056173

    申请日：2016-03-21

    Applicant: UNIVERSITY OF ULSTER

    Inventor： LEACOCK, Alan

    IPC: B21D25/02 ,  B21D25/04 ,  B21D53/92

    CPC classification number: B21D25/02 ,  B21D22/18 ,  B21D22/26 ,  B21D25/04 ,  B21D53/92

    Abstract: A method of forming a compound curvature metal skin from a sheet metal blank comprising the steps of: •providing a blank (1) defining at least a sector of a truncated cone having a central axis of symmetry, a leading edge and a trailing edge; • providing an arcuate or annular punch (4) substantially corresponding in shape to an inner surface of the compound curvature metal skin and having an outer surface, a leading edge and an inner surface; • gripping the leading edge of the blank (1) between mating faces of a first blank holding means (6) located on a first side of the punch (4) adjacent the inner face of the punch; gripping the trailing edge of the blank (1) between mating faces of a second blank holding (8) means located on a second side of the punch (4, opposite to said first side and adjacent the outer face of the punch; • displacing the first and second blank holding means (6,8) with respect to the punch (4) in a single direction to draw the blank (1) over the punch (4) while permitting the blank (1) to flow between mating surfaces of at least one of the first and second blank holding means (6,8), comprising the steps of displacing each of the first and second blank holding means (6,8) with respect to the punch by different amounts and at different rates.

    Abstract translation: 一种从金属板坯形成复合曲率金属表皮的方法，包括以下步骤：提供限定具有中心对称轴的截头圆锥的至少扇形的坯料（1），前缘和后缘; •提供基本对应于形状的弧形或环形冲头（4）到复合曲率金属表皮的内表面并且具有外表面，前缘和内表面; •在位于所述冲头（4）的与所述冲头的内表面相邻的第一侧上的第一坯料保持装置（6）的配合面之间夹紧坯料（1）的前缘; 在位于冲头的第二侧面上的第二坯料夹持件（8）装置的配合面之间抓住坯料（1）的后缘，该第二坯料装置与所述第一侧相对并且邻近冲头的外表面; 第一和第二坯料保持装置（6,8）相对于冲头（4）在单一方向上以将坯料（1）拉过冲头（4），同时允许坯料（1）在配合表面之间流动 所述第一和第二坯料保持装置（6,8）中的至少一个包括以下步骤：使所述第一和第二坯料保持装置（6,8）中的每一个相对于所述冲头以不同的量和不同的速率移动。

    ESCULENTIN-2CHA PEPTIDE AND ANALOGUES THEREOF
    8.
    发明申请
    ESCULENTIN-2CHA PEPTIDE AND ANALOGUES THEREOF 审中-公开
    ESCULENTIN-2CHA肽及其类似物

    公开(公告)号：WO2015114148A1

    公开(公告)日：2015-08-06

    申请号：PCT/EP2015/052094

    申请日：2015-02-02

    Applicant: UNIVERSITY OF ULSTER

    Inventor： ABDEL-WAHAB, Yasser ,  FLATT, Peter ,  OJO, Opeolu ,  CONLON, J. Michael

    IPC: A61K38/17 ,  A61P3/08 ,  A61P3/10 ,  A61P3/06 ,  A61P5/50 ,  A61P9/10 ,  A61P3/04

    CPC classification number: C07K14/463 ,  A61K38/00

    Abstract: The present invention relates to an esculentin-2CHa peptide and analogues thereof, and the use each thereof in the treatment of diabetes, for example type 2 diabetes; insulin resistance; obesity, and/or hypercholesterolemia. Also disclosed is a pharmaceutical composition comprising peptides and analogues according to the present invention; use of peptides and analogues according to the present invention for the manufacture of a medicament for the treatment of diabetes, insulin resistance, obesity, and/or hypercholesterolemia; and methods of treating diabetes, insulin resistance, obesity, and/or hypercholesterolemia.

    Abstract translation: 本发明涉及一种esculentin-2CHα肽及其类似物，以及其用于治疗糖尿病的用途，例如2型糖尿病; 胰岛素抵抗; 肥胖症和/或高胆固醇血症。 还公开了包含根据本发明的肽和类似物的药物组合物; 使用根据本发明的肽和类似物来制备用于治疗糖尿病，胰岛素抵抗，肥胖和/或高胆固醇血症的药物; 以及治疗糖尿病，胰岛素抵抗，肥胖和/或高胆固醇血症的方法。

    BLAST RESISTANT STRUCTURES
    9.
    发明申请
    BLAST RESISTANT STRUCTURES 审中-公开
    耐火结构

    公开(公告)号：WO2014087174A1

    公开(公告)日：2014-06-12

    申请号：PCT/GB2013/053228

    申请日：2013-12-06

    Applicant: UNIVERSITY OF ULSTER

    Inventor： ALI, Faris Abed Al-Hafidh

    IPC: F41H5/007 ,  E04C2/32 ,  F42D5/045

    CPC classification number: F41H5/24 ,  E04C2/06 ,  E04C2/328 ,  E04C2/46 ,  E04C2/528 ,  E04C5/012 ,  E04F13/072 ,  F41H5/007 ,  F42D5/045

    Abstract: A panel, wall or structure that can use its curvature to resist blast forces. Such a panel has a two-dimensional footprint defined by a height L and a curvature defined by a maximum lateral displacement x in a direction perpendicular to its footprint and towards a source of a blast. The curvature is chosen in the range of 0.001≤ x/L ≤ 0.5 so as to provide an improvement in blast resistance for the same panel thickness.

    Abstract translation: 可以使用其曲率来抵抗爆炸力的面板，墙壁或结构。 这种面板具有由垂直于其覆盖区域并朝向爆炸源的方向上由最大横向位移x限定的高度L和曲率限定的二维空间。 曲率选择在0.001≤x/L≤0.5的范围内，以提供相同面板厚度的抗风​​化性能的改善。

    FORMWORK FOR A CONSTRUCTION
    10.
    发明申请
    FORMWORK FOR A CONSTRUCTION 审中-公开
    建筑工程

    公开(公告)号：WO2013076464A2

    公开(公告)日：2013-05-30

    申请号：PCT/GB2012/052851

    申请日：2012-11-16

    Applicant: UNIVERSITY OF ULSTER

    Inventor： SODEN, Julie Alexandra

    CPC classification number: D03D11/02 ,  D03D25/005 ,  D10B2403/0241

    Abstract: A woven formwork for construction of a structure is disclosed. The formwork comprises a three-dimensional woven fabric arranged so as to define one or more cavities into which an in-fill material can be inserted in order to construct said structure.

    Abstract translation: 公开了一种用于构造结构的编织模板。 模板包括布置成限定一个或多个空腔的三维织造织物，为了构造所述结构，可以插入填充材料。

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