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    BIOLOGICAL FLUID SEPARATION DEVICE
    2.
    发明申请
    BIOLOGICAL FLUID SEPARATION DEVICE 审中-公开
    生物流体分离装置

    公开(公告)号：WO2017214498A1

    公开(公告)日：2017-12-14

    申请号：PCT/US2017/036747

    申请日：2017-06-09

    申请人： BECTON, DICKINSON AND COMPANY

    发明人： XU, Qihua ,  WANG, Gonghao

    IPC分类号： G01N33/49 ,  B01L3/00

    CPC分类号： A61B5/150755 ,  A61B5/150251 ,  B01D61/18 ,  B01D2325/02 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/049 ,  G01N33/491

    摘要： A blood separation device adapted to receive a blood sample having a whole blood portion and a plasma portion is disclosed. The blood separation device includes a housing defining a first chamber, a second chamber, and a separation member disposed therebetween. The blood separation device also includes an actuator, wherein actuation of the actuator draws the blood sample into the first chamber and the separation member is adapted to allow the plasma portion to pass through the separation member to the second chamber. The blood separation device matches the plasma chamber volume, the blood chamber volume, and the applied single pressure source so that the correct trans-membrane pressure and shear rate is obtained.

    摘要翻译： 公开了一种适用于接收具有全血部分和血浆部分的血液样本的血液分离装置。 血液分离装置包括限定第一腔室，第二腔室和设置在其间的分离构件的壳体。 血液分离装置还包括致动器，其中致动器的致动将血液样本抽入第一腔室，并且分离构件适于允许血浆部分通过分离构件到达第二腔室。 血液分离装置与血浆室容积，血液室容积和施加的单一压力源匹配，从而获得正确的跨膜压力和剪切速率。

    NUCLEIC ACID STABILIZATION AGENT
    3.
    发明申请
    NUCLEIC ACID STABILIZATION AGENT 审中-公开
    核酸稳定剂

    公开(公告)号：WO2017198715A1

    公开(公告)日：2017-11-23

    申请号：PCT/EP2017/061848

    申请日：2017-05-17

    申请人： R-BIOPHARM AG

    发明人： LOEWE, Robert

    IPC分类号： A01N1/02 ,  C12Q1/68 ,  A61B5/15 ,  C12N15/10

    CPC分类号： C12Q1/6806 ,  A01N1/021 ,  A61B5/150755 ,  C12N15/1003 ,  C12Q2527/125

    摘要： The invention relates to a method, kit and sample collection container for stabilizing nucleic acids in a sample. The invention is based on treating a biological sample, such as body fluids, in particular blood, urine, sputum, or other samples containing biological cells or obtained from a mammalian organism, with one or more salts, comprising at least one salt according to the general Formula I, preferably comprising treating a sample with ammonium formate. The invention further relates to a method for the detection and/or isolation of a nucleic acid from a sample including, or subsequent to, the method for stabilizing said nucleic acids according to the invention, in particular wherein said sample comprises the salts of the invention after having been treated using the method of the invention. The invention also provides a kit for the detection, isolation and/or stabilization of nucleic acids from a biological sample and a collection container configured for the isolation of a biological, preferably blood sample.

    摘要翻译： 本发明涉及用于稳定样品中核酸的方法，试剂盒和样品收集容器。 本发明基于用一种或多种盐处理生物样品，例如体液，尤其是血液，尿液，痰或含有生物细胞或从哺乳动物生物体获得的其他样品，所述盐包含至少一种根据 通式I，优选包括用甲酸铵处理样品。 本发明进一步涉及用于从样品中检测和/或分离核酸的方法，所述方法包括或在根据本发明稳定所述核酸的方法之后，特别是其中所述样品包含本发明的盐 在使用本发明的方法处理之后。 本发明还提供了用于检测，分离和/或稳定来自生物样品和收集容器的核酸的试剂盒，所述收集容器被配置用于分离生物优选血液样品。

    DIAGNOSTIC CARTRIDGE, FLUID STORAGE AND DELIVERY APPARATUS THEREFOR AND METHODS OF CONSTRUCTION THEREOF
    6.
    发明申请
    DIAGNOSTIC CARTRIDGE, FLUID STORAGE AND DELIVERY APPARATUS THEREFOR AND METHODS OF CONSTRUCTION THEREOF 审中-公开
    诊断盒，流体储存和输送装置及其构造方法

    公开(公告)号：WO2016123455A1

    公开(公告)日：2016-08-04

    申请号：PCT/US2016/015596

    申请日：2016-01-29

    申请人： WRIGHT, David, W.

    发明人： WRIGHT, David, W.

    IPC分类号： A61B5/15 ,  A61B5/157

    CPC分类号： B01L3/502707 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/157 ,  A61B2562/0295 ,  B01L3/502738 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/047 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0633 ,  B01L2400/0638 ,  B01L2400/0683

    摘要： A disposable, point-of-care diagnostic cartridge (10) has a base (14) with a reaction chamber (18) and an inlet (26) and a fluidic channel (16) extending therebetween. An apparatus (12) is fixed to the base. The apparatus includes a flexible upper layer (32) having a reservoir (38) containing fluid (22) therein; a flexible lower layer (36), and a rigid substrate (34) sandwiched between the upper and lower layers. The upper layer is fixed to the substrate with a first adhesive having a first bond force. The lower layer has a valve member (24) in fluid communication with a through port (23) in the base and the base inlet The valve member has a closed state (Fig. 3A) to seal off the through port and the inlet from fluid communication and an open state (Fig. 3B) to bring the through port and the inlet into fluid communication. The valve member is moveable from the closed state to the open state under a force less than the first bond force.

    摘要翻译： 一次性护理诊断卡盒（10）具有带有反应室（18）和在其间延伸的入口（26）和流体通道（16）的底座（14）。 装置（12）固定在基座上。 该装置包括具有在其中容纳流体（22）的储存器（38）的柔性上层（32） 柔性下层（36）和夹在上层和下层之间的刚性衬底（34）。 上层用具有第一粘合力的第一粘合剂固定到基底上。 下层具有与基座中的通孔（23）流体连通的阀构件（24）和基座入口。阀构件具有关闭状态（图3A）以密封通孔和入口与流体 通信和打开状态（图3B），以使通过端口和入口流体连通。 阀构件在小于第一接合力的力下可从关闭状态移动到打开状态。

    SYRINGE FOR OBTAINING SUB-MICRON MATERIALS FOR SELECTIVE ASSAYS AND RELATED METHODS OF USE
    9.
    发明申请
    SYRINGE FOR OBTAINING SUB-MICRON MATERIALS FOR SELECTIVE ASSAYS AND RELATED METHODS OF USE 审中-公开
    用于获取选择性测定的亚微米材料的SYRINGE及相关使用方法

    公开(公告)号：WO2015131109A1

    公开(公告)日：2015-09-03

    申请号：PCT/US2015/018114

    申请日：2015-02-27

    申请人： LOCKHEED MARTIN CORPORATION

    发明人： MOUNTCASTLE, Paul D. ,  FOULKE, Svetlana M.

    IPC分类号： B01D27/14

    CPC分类号： C12Q1/24 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150732 ,  A61B5/150755 ,  A61B5/153

    摘要： A syringe for obtaining sub-micron components, including nano-sized components, from a solution includes a barrel having an interior, a needle extending from one end of the barrel, and a plunger received in the interior at an end of the barrel opposite the needle. A filter cartridge is positioned between the needle and the barrel, wherein the filter cartridge maintains at least one membrane having apertures of two distinct size ranges, and wherein operation of the plunger to draw the solution into the barrel allows for retention of sub-micron or nano-sized components of a size between the two distinct size ranges.

    摘要翻译： 用于从溶液中获得亚微米部件（包括纳米尺寸部件）的注射器包括具有内部的筒体，从所述筒体的一端延伸的针头以及容纳在所述筒体的与所述筒体相对的所述筒体的端部内部的柱塞 针。 滤筒位于针和筒之间，其中滤筒保持至少一个具有两个不同尺寸范围的孔的膜，并且其中柱塞将溶液吸入筒中的操作允许保留亚微米或 尺寸在两个不同尺寸范围之间的纳米级组件。