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    METHOD OF PREPARATION OF A SUBSTRATE CONTAINING CARBOXYBETAINE GROUPS AND BOUND BIOACTIVE SUBSTANCES WHICH IS RESISTANT AGAINST UNDESIRABLE DEPOSITION FROM BIOLOGICAL MEDIA
    3.
    发明申请
    METHOD OF PREPARATION OF A SUBSTRATE CONTAINING CARBOXYBETAINE GROUPS AND BOUND BIOACTIVE SUBSTANCES WHICH IS RESISTANT AGAINST UNDESIRABLE DEPOSITION FROM BIOLOGICAL MEDIA 审中-公开
    制备含有羧基乙酰乙酸基团的基质和结合生物活性物质的方法，所述生物活性物质抗生物介质中不可耐受的沉积

    公开(公告)号：WO2017215683A1

    公开(公告)日：2017-12-21

    申请号：PCT/CZ2017/050025

    申请日：2017-06-16

    Applicant: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I. ,  USTAV FOTONIKY A ELEKTRONIKY AV CR, V.V.I.

    Inventor： LISALOVA, Hana ,  BRYNDA, Eduard ,  VISOVA, Ivana ,  HOUSKA, Milan ,  SURMAN, Frantisek ,  MRKVOVA, Katerina ,  CHADTOVA SONG, Xue ,  HOMOLA, Jiri

    IPC: G01N33/543 ,  C08F122/22

    CPC classification number: G01N33/54353

    Abstract: The present invention relates to a method of preparation of a substrate surface containing carboxybetaine groups with bound bioactive substances, having resistance to undesirable deposition of biological media components on the substrate surface, comprising the steps of chemical activation of carboxybetaine groups on the surface of the substrate by converting the carboxybetaine carboxyl group into an active ester, covalent binding of a bioactive substance to some of the active esters, and reaction of the product from the previous step with an acid of general formula (I) NH 2 -(CH 2 -CH 2 -0) n -CH 2 -COOH, where n = 1 to 4, wherein the acid of general formula (I) reacts with those active esters, which have not undergone covalent bonding of the bioactive substance.

    Abstract translation: 本发明涉及一种用结合的生物活性物质制备含有羧基甜菜碱基团的基质表面的方法，所述基质表面具有抗生物介质组分在基质表面上的不希望的沉积，该方法包括以下步骤： 通过将羧基甜菜碱羧基转化成活性酯，将生物活性物质共价结合到一些活性酯上，并将前一步骤的产物与通式（I）的酸反应，从而在底物表面上形成羧基甜菜碱基团， NH <子> 2 - （CH <子> 2 -CH <子> 2 -0）<子>名词 -CH <子> 2 -COOH，其中n = 1至4，其中通式（I）的酸与那些没有经历生物活性物质共价结合的活性酯反应。

    COPOLYMER OF N-(2-HYDROXYPROPYL) METHACRYLAMIDE AND CARBOXYBETAINE METHACRYLAMIDE, POLYMER BRUSHES
    4.
    发明申请
    COPOLYMER OF N-(2-HYDROXYPROPYL) METHACRYLAMIDE AND CARBOXYBETAINE METHACRYLAMIDE, POLYMER BRUSHES 审中-公开
    N-（2-羟丙基）甲基丙烯酰胺与羧甲基丙烯酰胺，聚合物刷的共聚物

    公开(公告)号：WO2016177354A2

    公开(公告)日：2016-11-10

    申请号：PCT/CZ2016/050011

    申请日：2016-05-05

    Applicant: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I. ,  USTAV FOTONIKY A ELEKTRONIKY AV CR, V.V.I.

    Inventor： RODRIGUEZ-EMMENEGGER, Cesar ,  SURMAN, Frantisek ,  BRYNDA, Eduard ,  RIEDEL, Tomas ,  HOUSKA, Milan ,  LISALOVA, Hana ,  HOMOLA, Jiri

    IPC: C08F293/00

    CPC classification number: C08F293/005 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F220/56 ,  C08F2438/03 ,  C09D4/00 ,  C08F220/60 ,  C08L77/12

    Abstract: The present invention relates to the preparation and use of copolymers composed of N-(2- hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S-R-polymer (I) wherein S is a substrate; R is a residue of a polymerization initiator or a RAFT agent bound to the substrate; and "polymer" is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.

    Abstract translation: 本发明涉及由N-（2-羟丙基）甲基丙烯酰胺（HPMAA）和羧基甜菜碱甲基丙烯酰胺（CBMAA）组成的共聚物的制备和用途。 本发明进一步描述了具有结构1 S-R-聚合物（I）的聚合物刷子，其中S是基材; R是聚合引发剂或与底物结合的RAFT试剂的残基; 和“聚合物” 是N-（2-羟丙基）甲基丙烯酰胺和羧基甜菜碱甲基丙烯酰胺的共聚物。此外，描述了含有接枝到基材上或从基材接枝的无规或嵌段共聚物的这些聚合物刷的生产。 共聚物刷适用于保护基材免于沉积和/或粘附生物物质，和/或防止血栓形成。 通过将生物活性物质共价连接至CBMAA单体单元而功能化的刷特别适用于与不受非靶标化合物的非特异性沉积影响的靶生物物质的特异性相互作用。

    CONTACT AND INTRAOCULAR LENSES CONTAINING ULTRAVIOLET ABSORBERS AND METHOD OF THEIR PRODUCTION
    7.
    发明申请
    CONTACT AND INTRAOCULAR LENSES CONTAINING ULTRAVIOLET ABSORBERS AND METHOD OF THEIR PRODUCTION 审中-公开
    含有超紫外线吸收剂的接触和内窥镜及其生产方法

    公开(公告)号：WO1997001114A1

    公开(公告)日：1997-01-09

    申请号：PCT/CZ1996000016

    申请日：1996-06-19

    Applicant: USTAV MAKROMOLEKULARNI CHEMIE AKADEMIE VED C¿ESKÉ REPUBLIKY ,  USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED C¿ESKÉ REPUBLIKY ,  LABSKY, Jir¿í ,  VACIK, Jir¿í ,  C¿EJKOVA, Jitka

    Inventor： USTAV MAKROMOLEKULARNI CHEMIE AKADEMIE VED C¿ESKÉ REPUBLIKY ,  USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED C¿ESKÉ REPUBLIKY

    IPC: G02B01/04

    CPC classification number: G02B1/043 ,  C08L33/14

    Abstract: The invention concerns contact and intraocular lenses formed by a polymer from 89 to 99.6 % of vinyl monomers, 0.2 to 6 wt.% of polymerizable absorbers of ultraviolet radiation, 0.1 to 3 wt.% of a crosslinker and 0.1 to 2 wt.% of a polymerization initiator. As vinyl monomers, the monomers are used selected from the group comprising alkyl acrylates and methacrylates, hydroxyalkyl acrylates and methacrylates, fluoroalkyl acrylates and methacrylates, (alkyloxy)alkyl acrylates and methacrylates, (acyloxy)alkyl acrylates and methacrylates, (acylamino)alkyl acrylates and methacrylates, (alkylsulfinyl)alkyl acrylates and methacrylates, (alkylsulfonyl)alkyl acrylates and methacrylates, tris(alkyloxy)silylalkyl acrylates and methacrylates, N-vinylpyrrolidone, N-vinylpiperidone and their combinations. As polymerizable absorbers of ultraviolet radiation, substances selected from the group of substances comprising substances of general formula (I) or (II) are used where R , R are hydrogen, acryloyloxy, methacryloyloxy, (acryloyloxy)alkyloxy, (methacryloyloxy)alkyloxy, 3-(methacryloyloxy)-2-hydroxypropyloxy, vinyl, allyloxy, (acryloylamino)methyl, (methacryloylamino)methyl groups, R , R are hydrogen, hydroxy, halogen, cyano, alkyloxy, alkyl, (alkyloxy)alkyl, hydroxyalkyl groups, the alkyls being alkyl groups with 1 to 4 carbon atoms or (III) or (IV), where R is acryloyl or methacryloyl group, or their mixture. As cross-linking agents, substances are used selected from the group comprising acrylic and methacrylic esters of dihydric alcolhols, amino alcohols, amines, allyl acrylates and methacrylates and diallyl esters of dicarboxylic acids and as polymerization initiators, common azo and peroxy initiators and initiators cleavable by UV radiation.

    Abstract translation: 本发明涉及由聚合物形成的接触和眼内透镜，其中乙烯基单体为89-99.6％，紫外辐射聚合吸收剂为0.2-6％，交联剂为0.1-3wt％，交联剂为0.1-2wt％ 聚合引发剂。 作为乙烯基单体，使用选自以下的单体：丙烯酸烷基酯和甲基丙烯酸烷基酯，丙烯酸羟烷基酯和甲基丙烯酸烷基酯，丙烯酸烷基酯和甲基丙烯酸氟烷基酯，丙烯酸酯和甲基丙烯酸烷基氧基烷基酯，（酰基氧基）烷基丙烯酸酯和甲基丙烯酸酯，（酰氨基）烷基丙烯酸酯和 （烷基亚磺酰基）烷基丙烯酸酯和甲基丙烯酸酯，（烷基磺酰基）烷基丙烯酸酯和甲基丙烯酸酯，三（烷氧基）甲硅烷基烷基丙烯酸酯和甲基丙烯酸酯，N-乙烯基吡咯烷酮，N-乙烯基哌啶酮及其组合。 作为紫外线辐射的聚合性吸收剂，使用选自含有通式（I）或（II）的物质的物质的物质，其中R 1，R 2为氢，丙烯酰氧基，甲基丙烯酰氧基，（丙烯酰氧基）烷氧基， （甲基丙烯酰氧基）烷氧基，3-（甲基丙烯酰氧基）-2-羟丙氧基，乙烯基，烯丙氧基，（丙烯酰氨基）甲基，（甲基丙烯酰氨基）甲基，R 3，R 4为氢，羟基，卤素，氰基， 烷基，（烷氧基）烷基，羟基烷基，烷基是具有1至4个碳原子的烷基或（III）或（IV），其中R是丙烯酰基或甲基丙烯酰基，或它们的混合物。 作为交联剂，使用选自二羟基醇，氨基醇，胺，丙烯酸烯丙酯和甲基丙烯酸酯的丙烯酸和甲基丙烯酸酯和二羧酸的二烯丙基酯的聚合引发剂，常见的偶氮和过氧引发剂以及可分离的引发剂的组的物质 通过紫外线辐射。

    NEW MEDICAL FORMS WITH PROLONGED EFFECT APPLIED IN EYE MEDICINE AND THE METHOD FOR PREPARATION THEREOF
    8.
    发明申请
    NEW MEDICAL FORMS WITH PROLONGED EFFECT APPLIED IN EYE MEDICINE AND THE METHOD FOR PREPARATION THEREOF 审中-公开
    用于眼科药物的广泛效果的新型医疗形式及其制备方法

    公开(公告)号：WO1996024331A1

    公开(公告)日：1996-08-15

    申请号：PCT/CZ1996000006

    申请日：1996-02-06

    Applicant: USTAV MAKROMOLEKULARNI CHEMIE AKADEMIE VE¿D C¿ESKÉ REPUBLIKY ,  VUFB A.S. ,  FAKULTNI THOMAYEROVA NEMOCNICE ,  BLEHA, Miroslav ,  PRCHLIK, Jaroslav ,  SEDLAKOVA, Zden¿ka ,  BOUCHAL, Karel ,  SEDLAC¿EK, Karel

    Inventor： USTAV MAKROMOLEKULARNI CHEMIE AKADEMIE VE¿D C¿ESKÉ REPUBLIKY ,  VUFB A.S. ,  FAKULTNI THOMAYEROVA NEMOCNICE

    IPC: A61K09/06

    CPC classification number: A61K47/32 ,  A61K9/0048 ,  A61K47/58

    Abstract: The invention pertains to new medical forms of pharmaceutics with prolonged effect applied in eye medicine, which are formed by a pregel or gel based on the copolymers of 2-(2-carboxybenzoyloxy)ethyl methacrylate with methacrylate comonomers selected from the group comprising methyl methacrylate and butyl methacrylate, the carboxyl groups of which are at least in part modified and/or neutralized with at least one pharmaceutically active substance and/or neutralized with Na and/or K ions and/or organic bases and which contains, if it is desired, encapsulated another pharmaceutically active substances. One of the methods for the preparation of these new medical forms consists in at least partial neutralization of functional carboxyl groups of the latex, based on the copolymers of 2-(2-carboxybenzoyloxy)ethyl methacrylate with methacrylate comonomers selected from the group comprising methyl methacrylate and butyl methacrylate, with a basic pharmaceutically active substance and/or sodium hydroxide and/or potassium hydroxide and/or organic bases. The scope of the invented solution comprises also further methods for the preparation of the medical forms according to the invention.

    Abstract translation: 本发明涉及具有延长效应的眼科药物的新药物形式，其由基于2-（2-羧基苯甲酰氧基）乙基甲基丙烯酸酯与甲基丙烯酸酯共聚单体的共聚物与选自甲基丙烯酸甲酯和 甲基丙烯酸丁酯，其羧基至少部分用至少一种药物活性物质修饰和/或中和，和/或用Na +和/或K +和/或有机碱中和，并含有 如果需要的话，封装另一种药物活性物质。 基于2-（2-羧基苯甲酰氧基）乙基甲基丙烯酸酯与甲基丙烯酸甲酯共​​聚单体的共聚物，选自甲基丙烯酸甲酯的组合，制备这些新药物形式的方法之一包括至少部分中和乳胶的官能羧基 和甲基丙烯酸丁酯，具有碱性药物活性物质和/或氢氧化钠和/或氢氧化钾和/或有机碱。 本发明的方案的范围还包括用于制备根据本发明的医学形式的其它方法。

    METHOD FOR PREPARATION OF POLYMERIC MATERIALS
    9.
    发明申请
    METHOD FOR PREPARATION OF POLYMERIC MATERIALS 审中-公开
    制备聚合物材料的方法

    公开(公告)号：WO2017076379A1

    公开(公告)日：2017-05-11

    申请号：PCT/CZ2016/050040

    申请日：2016-10-31

    Applicant: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I.

    Inventor： KREDATUSOVA, Jana ,  BENES, Hynek

    IPC: C08K9/04 ,  C08G59/22 ,  C08G63/78 ,  C08G69/16

    CPC classification number: C08K9/04 ,  C08G63/785 ,  C08G69/16 ,  C08L77/02 ,  C08L67/04 ,  C08L63/00

    Abstract: Title of the invention: Method for preparation of polymeric materials The invention provides a method of preparation of a polymeric material, wherein at least one cyclic monomer is combined with hydrated layered double hydroxide of formula [M 2+ 1-xM 3 +x(OH)2(A m -)x/m], wherein A m is an m-valent anion, M 2+ is a divalent metal cation and M 3+ is a trivalent metal cation, the value x is in the range of 0.20

    Abstract translation: 本发明的标题：用于制备聚合物材料的方法本发明提供了一种制备聚合物材料的方法，其中至少一种环状单体与式[M >是m价阴离子，M 2 +是二价金属阳离子，M 3 +是三价金属阳离子，其值x在0.20 < ; x < 0.33，而水合的层状双氢氧化物通过含有0.1至9wt％的鏻阳离子的离子液体进行表面改性。 相对于水合层状双氢氧化物的重量，以环状单体与表面改性的层状双氢氧化物100/1至10/1的重量比计，并且所得悬浮液用电磁辐射以915 在150℃至250℃的温度下，优选3分钟至120分钟，

    MACROMOLECULAR CONJUGATES FOR ISOLATION, IMMOBILIZATION AND VISUALIZATION OF PROTEINS
    10.
    发明申请
    MACROMOLECULAR CONJUGATES FOR ISOLATION, IMMOBILIZATION AND VISUALIZATION OF PROTEINS 审中-公开
    用于分离，免疫和可视化蛋白质的大分子结合蛋白

    公开(公告)号：WO2016112882A3

    公开(公告)日：2016-08-25

    申请号：PCT/CZ2016050002

    申请日：2016-01-13

    Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I ,  USTAV MAKROMOLEKULARNI CHEMIE AV CR V V I ,  UNIVERZITA KARLOVA V PRAZE PRIRODOVEDECKA FAKULTA

    Inventor： SACHA PAVEL ,  KONVALINKA JAN ,  SCHIMER JIRI ,  KNEDLIK TOMAS ,  SUBR VLADIMIR ,  ULBRICH KAREL ,  STROHALM JIRI

    IPC: G01N33/531 ,  C08F20/58 ,  C08F220/58 ,  G01N33/532 ,  G01N33/533 ,  G01N33/534

    CPC classification number: G01N33/532 ,  C08F8/30 ,  G01N33/531 ,  G01N33/533 ,  G01N33/534 ,  G01N33/58 ,  G01N33/582

    Abstract: Macromolecular conjugates for isolation, immobilization and visualization of proteins The invention provides a synthetic macromolecular conjugate for selective interaction with proteins, comprising a synthetic copolymer, and at least one binding group and at least one further group selected from an affinity tag and an imaging probe, said at least one binding group and at least one further group being bound via covalent bond to said synthetic copolymer. The macromolecular conjugate is suitable in particular for identification, visualization, quantification or isolation of proteins and/ or cells. HPMA copolymer, i.e.poly(HPMA-co-Ma-β-Ala-TT), a copolymer prepared by conventional solution radical polymerization or controlled radical copolymerization (e.g. RAFT copolymerization, reversible addition-fragmentation chain-transfer) of N-(2- hydroxypropyl) methacrylamide (HPMA) and 3-(3-methacrylamidopropanoyl) thiazolidine-2-thione (Ma-P-Ala-TT) can be preferably used as the basic copolymer.

    Abstract translation: 用于蛋白质分离，固定和可视化的大分子缀合物本发明提供了一种用于与蛋白质选择性相互作用的合成大分子缀合物，其包含合成共聚物，以及至少一个结合基团和至少一个选自亲和标签和成像探针的其它基团， 所述至少一个结合基团和至少一个另外的基团通过共价键与所述合成共聚物结合。 大分子缀合物特别适用于蛋白质和/或细胞的鉴定，可视化，定量或分离。 HPMA共聚物，iepoly（HPMA-co-Ma-β-Ala-TT），通过常规溶液自由基聚合或受控自由基共聚制备的共聚物（例如RAFT共聚，可逆加成 - 断裂链转移）N-（2- 羟丙基）甲基丙烯酰胺（HPMA）和3-（3-甲基丙烯酰胺丙酰基）噻唑烷-2-硫酮（Ma-P-Ala-TT）。

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