公开(公告)号：WO2012109285A2

公开(公告)日：2012-08-16

申请号：PCT/US2012024201

申请日：2012-02-07

Applicant: MEDIMMUNE LLC ,  SELLMAN BRET ,  TKACZYK CHRISTINE ,  HUA LEI ,  CHOWDHURY PARTHA ,  VARKEY REENA ,  DAMSCHRODER MELISSA ,  PENG LI ,  OGANESYAN VAHEH ,  HILLIARD JAMESE JOHNSON

Inventor： SELLMAN BRET ,  TKACZYK CHRISTINE ,  HUA LEI ,  CHOWDHURY PARTHA ,  VARKEY REENA ,  DAMSCHRODER MELISSA ,  PENG LI ,  OGANESYAN VAHEH ,  HILLIARD JAMESE JOHNSON

IPC: A61K39/40 ,  G01N33/569

CPC classification number: C07K16/1271 ,  A61K38/14 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  G01N33/56938 ,  G01N2333/31 ,  G01N2800/20 ,  G01N2800/44 ,  G01N2800/709 ,  A61K2300/00

Abstract: Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.

Abstract translation: 本文提供了与抗-α毒素抗体和片段有关的组合物，制备方法和使用方法。

公开(公告)号：WO2012109285A3

公开(公告)日：2012-08-16

申请号：PCT/US2012/024201

申请日：2012-02-07

Applicant: MEDIMMUNE, LLC ,  SELLMAN, Bret ,  TKACZYK, Christine ,  HUA, Lei ,  CHOWDHURY, Partha ,  VARKEY, Reena ,  DAMSCHRODER, Melissa ,  PENG, Li ,  OGANESYAN, Vaheh ,  HILLIARD, Jamese, Johnson

Inventor： SELLMAN, Bret ,  TKACZYK, Christine ,  HUA, Lei ,  CHOWDHURY, Partha ,  VARKEY, Reena ,  DAMSCHRODER, Melissa ,  PENG, Li ,  OGANESYAN, Vaheh ,  HILLIARD, Jamese, Johnson

IPC: C12P21/08 ,  C07K16/00 ,  A61K39/40 ,  A61K39/085

Abstract: The disclosure provides compositions, methods of manufacture and methods of use of antibodies and fragments that bind Staphylococcus aureus alpha toxin. More specifically, the disclosure provides VH CDR and VL CDR region sequences of antibodies or antigen-binding fragments. Method of preventing, treating or managing a condition associated with Staphylococcus aureus infection using the antibodies are also disclosed.

公开(公告)号：WO2015157238A2

公开(公告)日：2015-10-15

申请号：PCT/US2015/024650

申请日：2015-04-07

Applicant: MEDIMMUNE, LLC ,  ETTINGER, Catherine ,  KARNELL, Jodi ,  DAMSCHRODER, Melissa ,  CHOWDHURY, Partha ,  XIAO, Xiaodong ,  TSUI, Ping ,  VARKEY, Reena ,  DRABIC, Stacey ,  CARTER, Laura ,  HERBST, Ronald ,  DU, Qun ,  NAIMAN, Brian, Michael

Inventor： ETTINGER, Catherine ,  KARNELL, Jodi ,  DAMSCHRODER, Melissa ,  CHOWDHURY, Partha ,  XIAO, Xiaodong ,  TSUI, Ping ,  VARKEY, Reena ,  DRABIC, Stacey ,  CARTER, Laura ,  HERBST, Ronald ,  DU, Qun ,  NAIMAN, Brian, Michael

IPC: A61K39/395

CPC classification number: A61K39/3955 ,  A61K2039/505 ,  A61K2121/00 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/53

Abstract: This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21 -mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof.

Abstract translation: 本公开提供了IL-21结合分子，例如抗IL-21抗体及其抗原结合片段。 在某些方面，抗IL-21抗体及其片段可以是杂交瘤衍生的鼠单克隆抗体及其人源化形式。 在某些方面，本文提供的结合分子（例如抗IL-21抗体及其抗原结合片段）抑制，抑制或拮抗IL-21活性。 此外，本公开内容提供了用于诊断和治疗与IL-21介导的信号转导相关的疾病或病症例如炎性，免疫介导或自身免疫性疾病或病症的组合物和方法。 在一个具体的实施方案中，本公开提供了使用IL-21结合分子（例如抗IL-21抗体及其抗原结合片段）治疗或预防移植物抗宿主病（GVHD）的方法。