公开(公告)号：WO2007130646A3

公开(公告)日：2008-11-20

申请号：PCT/US2007010958

申请日：2007-05-04

Applicant: UNIV ROCKEFELLER ,  RICE CHARLES ,  EVANS MATTHEW J ,  VON HAHN THOMAS

Inventor： RICE CHARLES ,  EVANS MATTHEW J ,  VON HAHN THOMAS

IPC: C07K16/00

CPC classification number: C07K16/28 ,  C07K16/2896 ,  C07K2317/76

Abstract: The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.

Abstract translation: 本发明涉及发现紧密连接蛋白-1蛋白质作为HCV进入细胞的共同受体。 提供了通过抑制与Claudin-1的HCV相互作用来抑制，预防或减轻HCV感染的方法。 还提供了鉴定干扰HCV与Claudin-1相互作用的试剂或化合物的方法。 最后，还公开了与抑制与Claudin-1的HCV相互作用有关的有用的试剂盒，细胞培养组合物，试剂和化合物。

公开(公告)号：WO2007130646A2

公开(公告)日：2007-11-15

申请号：PCT/US2007/010958

申请日：2007-05-04

Applicant: THE ROCKEFELLER UNIVERSITY ,  RICE, Charles ,  EVANS, Matthew J. ,  VON HAHN, Thomas

Inventor： RICE, Charles ,  EVANS, Matthew J. ,  VON HAHN, Thomas

IPC: A61K39/42

CPC classification number: C07K16/28 ,  C07K16/2896 ,  C07K2317/76

Abstract: The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.

Abstract translation: 本发明涉及发现紧密连接蛋白-1蛋白质作为HCV进入细胞的共同受体。 提供了通过抑制与Claudin-1的HCV相互作用来抑制，预防或减轻HCV感染的方法。 还提供了鉴定干扰HCV与Claudin-1相互作用的试剂或化合物的方法。 最后，还公开了与抑制与Claudin-1的HCV相互作用相关的有用的试剂盒，细胞培养组合物，试剂和化合物。