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公开(公告)号：WO2022046800A2
公开(公告)日：2022-03-03
申请号：PCT/US2021/047388
申请日：2021-08-24
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , THE METHODIST HOSPITAL SYSTEM , WANG, Rongfu , WANG, Yicheng , ZHU, Motao
发明人： WANG, Rongfu , WANG, Yicheng , ZHU, Motao
IPC分类号： C07K19/00 , A61K47/42 , C07K14/00 , C07K14/435 , C07K14/705
摘要： Disclosed herein are recombinant proteins and/or polypeptides comprising a Beclin 2 polypeptide and/or a targeting moiety and methods relating to treating, preventing, reducing, and/or inhibiting a cancer, metastasis, and/or a neurodegenerative disease comprising administering said recombinant protein or polypeptides.
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2.发明申请REVERSAL OF THE SUPPRESSIVE FUNCTION OF SPECIFIC T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING 审中-公开特异性T细胞通过类似受体8信号的抑制功能的反转
公开(公告)号：WO2007143582A3
公开(公告)日：2008-11-27
申请号：PCT/US2007070264
申请日：2007-06-01
发明人： WANG RONG-FU , PENG GUANGYONG , WANG YICHENG
CPC分类号： A61K31/7042 , C12N15/115 , C12N15/117
摘要： CD8+ regulatory T (Treg) cells and ?d Treg cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine- containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells, in specific embodiments. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides.
摘要翻译： CD8 +调节T（Treg）细胞和βdTreg细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 在特定的实施方案中，这种作用似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的接合而转导。 人TLR8天然配体对Treg细胞的刺激重现了含有合成含鸟苷酸的寡核苷酸的作用。
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3.发明申请DIRECT REVERSAL OF THE SUPPRESSIVE FUNCTION OF CD4+ REGULATORY T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING 审中-公开通过类似感受器8信号对CD4 +调节性T细胞的抑制功能的直接反映
公开(公告)号：WO2006099021B1
公开(公告)日：2008-02-21
申请号：PCT/US2006008379
申请日：2006-03-09
发明人： WANG RONG-FU , PENG GUANGYONG , WANG YICHENG
IPC分类号： C12Q1/68 , C07H21/02 , C12N15/113 , C12N15/117
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/117 , C12N2310/111 , C12N2310/14 , C12N2310/17 , C12N2310/315
摘要： CD4 + regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .
摘要翻译： CD4 + T细胞调节T（Treg）细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 该效应似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的结合来转导。 人TLR8天然配体对Treg细胞的刺激重现了含有合成含鸟苷酸的寡核苷酸的作用。
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4.发明申请
公开(公告)号：WO2006099021A3
公开(公告)日：2006-09-21
申请号：PCT/US2006/008379
申请日：2006-03-09
发明人： WANG, Rong-Fu , PENG, Guangyong , WANG, Yicheng
摘要： CD4 + regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .
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5.发明申请REVERSAL OF THE SUPPRESSIVE FUNCTION OF SPECIFIC T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING 审中-公开特异性T细胞通过类似受体8信号的抑制功能的反转
公开(公告)号：WO2007143582A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/070264
申请日：2007-06-01
发明人： WANG, Rong-Fu , PENG, Guangyong , WANG, Yicheng
IPC分类号： A61K31/7042 , A61K38/02 , A61P35/00
CPC分类号： A61K31/7042 , C12N15/115 , C12N15/117
摘要： CD8+ regulatory T (Treg) cells and γδ Treg cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine- containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells, in specific embodiments. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides.
摘要翻译： CD8 +调节T（Treg）细胞和βdTreg细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 在特定的实施方案中，这种作用似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的接合而转导。 人TLR8天然配体对Treg细胞的刺激重现了含有合成含鸟苷酸的寡核苷酸的作用。
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6.发明申请DIRECT REVERSAL OF THE SUPPRESSIVE FUNCTION OF CD4+ REGULATORY T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING 审中-公开通过Toll样受体8信号传导直接逆转CD4 +调节性T细胞的抑制功能
公开(公告)号：WO2006099021A9
公开(公告)日：2006-12-07
申请号：PCT/US2006008379
申请日：2006-03-09
发明人： WANG RONG-FU , PENG GUANGYONG , WANG YICHENG
IPC分类号： A61K48/00 , C12N15/113 , C12N15/117
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/117 , C12N2310/111 , C12N2310/14 , C12N2310/17 , C12N2310/315
摘要： CD4 + regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .
摘要翻译： CD4 + / Treg调节性T（Treg）细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制期望的免疫应答如抗肿瘤免疫性。 合成的硫代磷酸酯保护的含鸟苷的寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突细胞。 该效应似乎通过Toll样受体（TLR）8的信号转导和Treg细胞中MyD88和IRAK4分子的接合而被转导。 用人TLR8的天然配体刺激Treg细胞再现了合成的含鸟苷寡核苷酸的作用。
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7.发明申请DIRECT REVERSAL OF THE SUPPRESSIVE FUNCTION OF CD4+ REGULATORY T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING 审中-公开CD4 +调节性T细胞通过类似受体8信号的抑制功能的直接逆转
公开(公告)号：WO2006099021A2
公开(公告)日：2006-09-21
申请号：PCT/US2006008379
申请日：2006-03-09
发明人： WANG RONG-FU , PENG GUANGYONG , WANG YICHENG
IPC分类号： A61K48/00 , C12N15/113 , C12N15/117
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/117 , C12N2310/111 , C12N2310/14 , C12N2310/17 , C12N2310/315
摘要： CD4 + regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .
摘要翻译： CD4 + T细胞调节T（Treg）细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸的寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 该效应似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的结合来转导。 人TLR8天然配体对Treg细胞的刺激重现了含有合成含鸟苷的寡核苷酸的作用。
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