公开(公告)号：WO2016004189A1

公开(公告)日：2016-01-07

申请号：PCT/US2015/038807

申请日：2015-07-01

Applicant: NULWALA, Hunaid B. ,  WATKINS, John D.

Inventor： NULWALA, Hunaid B. ,  WATKINS, John D.

IPC: C25D3/66 ,  C25D3/44 ,  H01M10/0568 ,  H01M10/0569 ,  H01M10/054

CPC classification number: C25D3/665 ,  C25D3/44 ,  H01M10/054 ,  H01M10/0566 ,  H01M2300/0045

Abstract: A selected electrolyte composition comprising aluminum and a lower molecular weight fluorinated organic anion which can be an ionic liquid. The fluorinated organic anion can be bis(trifluorosulfonyl)imide. The composition can be used in electroplating or batteries. A preferred example is use of Al(NTf 2 ) 3 with one or more other moieties. A moisture insensitive electroplating method comprising: providing at least one aluminum electroplating system comprising at least one electroplating composition which is adapted for electroplating aluminum onto a substrate; electroplating aluminum onto the substrate from the at least one electroplating composition comprising: (i) aluminum cation, and (ii) at least one anion which is a fluorinated organic anion having molecular weight of 750 g/mol or less. Optionally, the aluminum cation is in, or is not in, aluminate form. Use of highly reactive aluminum compounds such as aluminum halides can be avoided.

Abstract translation: 一种选择的电解质组合物，其包含可以是离子液体的铝和较低分子量的氟化有机阴离子。 氟化有机阴离子可以是双（三氟磺酰基）酰亚胺。 该组合物可用于电镀或电池。 优选的实例是使用Al（NTf2）3与一个或多个其它部分。 一种不透湿电镀方法，包括：提供至少一种铝电镀系统，其包括至少一种适用于将铝电镀到基底上的电镀组合物; 从所述至少一种电镀组合物将铝电镀到所述基材上，所述电镀组合物包含：（i）铝阳离子，和（ii）至少一种阴离子，其是分子量为750g / mol或更低的氟化有机阴离子。 任选地，铝阳离子是或不是铝酸盐形式。 可以避免使用高活性铝化合物如卤化铝。

公开(公告)号：WO2011057135A3

公开(公告)日：2011-08-18

申请号：PCT/US2010055718

申请日：2010-11-05

Applicant: CERAMATEC INC ,  BOXLEY CHETT ,  COORS WILLIAM GROVER ,  WATKINS JOHN

Inventor： BOXLEY CHETT ,  COORS WILLIAM GROVER ,  WATKINS JOHN

IPC: H01M2/14 ,  H01M2/16 ,  H01M2/26

CPC classification number: H01M10/0569 ,  H01M2/1646 ,  H01M4/38 ,  H01M4/381 ,  H01M4/40 ,  H01M4/52 ,  H01M10/05 ,  H01M10/054 ,  H01M10/056 ,  H01M10/0562 ,  H01M10/0567 ,  H01M10/30 ,  H01M10/3909 ,  H01M10/3918 ,  H01M2300/0028 ,  H01M2300/0045 ,  H01M2300/0071 ,  Y02E60/12

Abstract: The present invention provides a solid-state sodium-based secondary cell (or rechargeable battery) (10). The secondary cell (10) comprises a solid sodium metal negative electrode (20) that is disposed in a non-aqueous negative electrolyte solution (25) that includes an ionic liquid. Additionally, the cell (10) comprises a positive electrode (35) that is disposed in a positive electrolyte solution (40). A sodium ion conductive electrolyte membrane (45) separates the negative electrolyte solution (25) from the positive electrolyte solution (40). The cell may operate at room temperature. Additionally, where the negative electrolyte solution (25) contains the ionic liquid, the ionic liquid may impede dendrite formation on the surface of the negative electrode (20) as the cell (10) is recharged and sodium ions are reduced onto the negative electrode (20).

Abstract translation: 本发明提供一种固态钠基二次电池（或可再充电电池）（10）。 二次电池（10）包括设置在包含离子液体的非水性负电解质溶液（25）中的固体钠金属负极（20）。 另外，电池（10）包括设置在正电解质溶液（40）中的正电极（35）。 钠离子传导性电解质膜（45）将负极电解质溶液（25）与正极电解液（40）分离。 电池可以在室温下运行。 此外，当负电解质溶液（25）含有离子液体时，当电池（10）被再充电并且钠离子还原到负极上时，离子液体可能阻碍负极（20）的表面上的枝晶形成 20）。

公开(公告)号：WO2009032313A1

公开(公告)日：2009-03-12

申请号：PCT/US2008/010435

申请日：2008-09-05

Applicant: CERAMATEC, INC. ,  GORDON, John, Howard ,  WATKINS, John, J.

Inventor： GORDON, John, Howard ,  WATKINS, John, J.

IPC: H01M4/58

CPC classification number: H01M4/136 ,  H01M4/5815 ,  H01M10/0562

Abstract: A lithium-sulfur battery (100) is disclosed in one embodiment of the invention as including an anode (102) containing lithium and a cathode (104) comprising elemental sulfur. The cathode may include at least one solvent selected to at least partially dissolve the elemental sulfur and Li2S x . A substantially non-porous lithium-ion-conductive membrane (106) is provided between the anode (102) and the cathode (104) to keep sulfur or other reactive species from migrating therebetween. In certain embodiments, the lithium-sulfur battery (100) may include a separator between the anode (102) and the non-porous lithium-ion-conductive membrane (106). This separator may prevent the lithium in the anode (102) from reacting with the non-porous lithium-ion-conductive membrane (106). In certain embodiments, the separator is a porous separator infiltrated with a lithium-ion-conductive electrolyte.

Abstract translation: 在本发明的一个实施方案中公开了锂硫电池（100），其包括含有锂的阳极（102）和包含元素硫的阴极（104）。 阴极可以包括至少一种选择成至少部分地溶解元素硫和Li 2 S x的溶剂。 在阳极（102）和阴极（104）之间提供基本上无孔的锂离子传导膜（106），以保持硫或其它反应物质不会在其间迁移。 在某些实施方案中，锂 - 硫电池（100）可以包括阳极（102）和无孔锂离子传导膜（106）之间的隔板。 该隔板可以防止阳极（102）中的锂与无孔锂离子传导膜（106）反应。 在某些实施方案中，分离器是渗透有锂离子传导电解质的多孔分离器。

公开(公告)号：WO2002085941A3

公开(公告)日：2002-10-31

申请号：PCT/EP2002/002218

申请日：2002-03-01

Applicant: MERCK PATENT GMBH ,  CARR, Francis, J. ,  CARTER, Graham ,  JONES, Tim ,  BAKER, Matthew ,  WATKINS, John ,  HANLON, Marian

Inventor： CARR, Francis, J. ,  CARTER, Graham ,  JONES, Tim ,  BAKER, Matthew ,  WATKINS, John ,  HANLON, Marian

IPC: C07K14/56

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular to the modification of human interferon alpha and specifically interferon alpha 2(INFα2) to result in proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when use in vivo .

公开(公告)号：WO2002085941A2

公开(公告)日：2002-10-31

申请号：PCT/EP2002/002218

申请日：2002-03-01

Applicant: MERCK PATENT GMBH ,  CARR, Francis, J. ,  CARTER, Graham ,  JONES, Tim ,  BAKER, Matthew ,  WATKINS, John ,  HANLON, Marian

Inventor： CARR, Francis, J. ,  CARTER, Graham ,  JONES, Tim ,  BAKER, Matthew ,  WATKINS, John ,  HANLON, Marian

IPC: C07K14/56

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K14/56

Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular to the modification of human interferon alpha and specifically interferon alpha 2(INFα2) to result in proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when use in vivo .

Abstract translation: 本发明涉及特别用于人，特别是用于治疗用途的多肽。 所述多肽是修饰的多肽，其中所述修饰导致多肽在施用于人受试者时引起免疫应答的倾向降低。 本发明特别涉及人干扰素α和特异性干扰素α2（INFα2）的修饰，以产生当在体内使用时与任何未修饰的对应物基本上不具有免疫原性或较低免疫原性的蛋白质。

公开(公告)号：WO2012142174A1

公开(公告)日：2012-10-18

申请号：PCT/US2012/033142

申请日：2012-04-11

Applicant: ELECTRONIC BIOSCIENCES INC. ,  ERVIN, Eric ,  WATKINS, John, J. ,  BARRALL, Geoffrey

Inventor： ERVIN, Eric ,  WATKINS, John, J. ,  BARRALL, Geoffrey

IPC: C12Q1/68 ,  G01N33/53 ,  B82Y5/00 ,  B82Y15/00

CPC classification number: G01N27/3278 ,  B82Y15/00 ,  G01N33/48721 ,  G01N33/54386 ,  G01N33/54393 ,  G01N33/551

Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.

Abstract translation: 提供了现场特异性化学修饰的纳米孔装置及其制造和使用方法。 例如，现场特异性化学修饰的纳米孔装置可用于分析物的感测和分析。

公开(公告)号：WO2011057135A2

公开(公告)日：2011-05-12

申请号：PCT/US2010055718

申请日：2010-11-05

Applicant: CERAMATEC INC ,  BOXLEY CHETT ,  COORS WILLIAM GROVER ,  WATKINS JOHN

Inventor： BOXLEY CHETT ,  COORS WILLIAM GROVER ,  WATKINS JOHN

IPC: H01M2/14 ,  H01M2/16 ,  H01M2/26

CPC classification number: H01M10/0569 ,  H01M2/1646 ,  H01M4/38 ,  H01M4/381 ,  H01M4/40 ,  H01M4/52 ,  H01M10/05 ,  H01M10/054 ,  H01M10/056 ,  H01M10/0562 ,  H01M10/0567 ,  H01M10/30 ,  H01M10/3909 ,  H01M10/3918 ,  H01M2300/0028 ,  H01M2300/0045 ,  H01M2300/0071 ,  Y02E60/12

Abstract: The present invention provides a solid-state sodium-based secondary cell (or rechargeable battery) (10). The secondary cell (10) comprises a solid sodium metal negative electrode (20) that is disposed in a non-aqueous negative electrolyte solution (25) that includes an ionic liquid. Additionally, the cell (10) comprises a positive electrode (35) that is disposed in a positive electrolyte solution (40). A sodium ion conductive electrolyte membrane (45) separates the negative electrolyte solution (25) from the positive electrolyte solution (40). The cell may operate at room temperature. Additionally, where the negative electrolyte solution (25) contains the ionic liquid, the ionic liquid may impede dendrite formation on the surface of the negative electrode (20) as the cell (10) is recharged and sodium ions are reduced onto the negative electrode (20).

Abstract translation: 本发明提供了一种固态钠基二次电池（或可再充电电池）（10）。 二次电池（10）包括设置在包含离子液体的非水性负电解质溶液（25）中的固体钠金属负电极（20）。 另外，电池（10）包括设置在正电解质溶液（40）中的正电极（35）。 钠离子导电电解质膜（45）将负电解质溶液（25）与正电解质溶液（40）分离。 电池可以在室温下运行。 此外，当负电解质溶液（25）含有离子液体时，当电池（10）被再充电并且钠离子被还原到负电极上时，离子液体可以阻止负电极（20）表面上的枝晶形成 20）。

公开(公告)号：WO2010107833A3

公开(公告)日：2010-09-23

申请号：PCT/US2010/027535

申请日：2010-03-16

Applicant: CERAMATEC, INC. ,  GORDON, John ,  WATKINS, John

Inventor： GORDON, John ,  WATKINS, John

IPC: H01M10/39 ,  H01M2/16

Abstract: A sodium-sulfur battery (100) is disclosed in one embodiment of the invention as including an anode (102) containing sodium and a cathode (104) comprising elemental sulfur. The cathode (104) may include at least one solvent selected to at least partially dissolve the elemental sulfur and Na 2 S x . A substantially non-porous sodium-ion-conductive membrane (106) is provided between the anode (102) and the cathode (104) to keep sulfur or other reactive species from migrating therebetween. In certain embodiments, the sodium-sulfur battery (100) may include a separator between the anode (102) and the non-porous sodium-ion-conductive membrane (106). This separator may prevent the sodium in the anode (102) from reacting with the non-porous sodium-ion-conductive membrane (106). In certain embodiments, the separator is a porous separator infiltrated with a sodium-ion-conductive electrolyte.

公开(公告)号：WO2010107833A2

公开(公告)日：2010-09-23

申请号：PCT/US2010027535

申请日：2010-03-16

Applicant: CERAMATEC INC ,  GORDON JOHN ,  WATKINS JOHN

Inventor： GORDON JOHN ,  WATKINS JOHN

IPC: H01M10/39 ,  H01M2/16 ,  H01M4/136 ,  H01M4/58 ,  H01M10/0562 ,  H01M10/36

CPC classification number: H01M10/0562 ,  H01M4/136 ,  H01M4/5815

Abstract: A sodium-sulfur battery (100) is disclosed in one embodiment of the invention as including an anode (102) containing sodium and a cathode (104) comprising elemental sulfur. The cathode (104) may include at least one solvent selected to at least partially dissolve the elemental sulfur and Na2Sx. A substantially non-porous sodium-ion-conductive membrane (106) is provided between the anode (102) and the cathode (104) to keep sulfur or other reactive species from migrating therebetween. In certain embodiments, the sodium-sulfur battery (100) may include a separator between the anode (102) and the non-porous sodium-ion-conductive membrane (106). This separator may prevent the sodium in the anode (102) from reacting with the non-porous sodium-ion-conductive membrane (106). In certain embodiments, the separator is a porous separator infiltrated with a sodium-ion-conductive electrolyte.

Abstract translation: 在本发明的一个实施方案中公开了钠硫电池（100），其包括含有钠和包含元素硫的阴极（104）的阳极（102）。 阴极（104）可以包括至少一种选择成至少部分溶解元素硫和Na 2 S x的溶剂。 在阳极（102）和阴极（104）之间提供基本上无孔的钠离子传导膜（106），以保持硫或其它反应物质不会在其间迁移。 在某些实施方案中，钠 - 硫电池（100）可以包括在阳极（102）和无孔钠离子传导膜（106）之间的隔膜。 该隔膜可以防止阳极（102）中的钠与无孔钠离子传导膜（106）反应。 在某些实施方案中，分离器是渗透有钠离子传导电解质的多孔分离器。

公开(公告)号：WO2005000891A2

公开(公告)日：2005-01-06

申请号：PCT/EP2004006887

申请日：2004-06-25

Applicant: MERCK PATENT GMBH ,  BAKER MATTHEW ,  WATKINS JOHN

Inventor： BAKER MATTHEW ,  WATKINS JOHN

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/52

CPC classification number: C07K14/524 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/57 ,  C07K2319/30

Abstract: The invention concerns human thrombopoietin and in particular modified forms of thrombopoietin (TPO) with improved properties. The improved proteins contain amino acid substitutions at specific positions within the TPO molecule. The invention provides modified TPO molecules, preferably fusion proteins comprising immunoglobulin constant regions and modified human TPO, with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

Abstract translation: 本发明涉及人血小板生成素，特别是具有改进性质的血小板生成素（TPO）的修饰形式。 改良的蛋白质在TPO分子内的特定位置含有氨基酸取代。 本发明提供了修饰的TPO分子，优选包含免疫球蛋白恒定区和修饰的人TPO的融合蛋白，其具有改善的生物学活性，伴随蛋白质中免疫原性潜力的降低。 改进的蛋白质旨在用于治疗人类疾病的治疗用途。