公开(公告)号：WO2010065736A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066578

申请日：2009-12-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  WEITZEL, William, F. ,  KIRKPATRICK, Anne E. ,  THOMPSON, David A. ,  ADDIS, Todd ,  WELCH, Christopher M. ,  KRUGER, Grant H. ,  WONG, Philip, M. ,  RAO, Panduranga S.

Inventor： WEITZEL, William, F. ,  KIRKPATRICK, Anne E. ,  THOMPSON, David A. ,  ADDIS, Todd ,  WELCH, Christopher M. ,  KRUGER, Grant H. ,  WONG, Philip, M. ,  RAO, Panduranga S.

IPC: A61B10/02 ,  A61M31/00 ,  A61B17/32

CPC classification number: A61B10/0275 ,  A61B17/0057 ,  A61B2010/0208 ,  A61B2017/00654

Abstract: A biopsy device assembly performs a biopsy of an anatomical tissue of a patient. The biopsy device assembly includes a housing and a biopsy device that extends out of the housing and that collects and cuts anatomical tissue from the patient. The biopsy device assembly further includes a hemostatic agent removably housed in the biopsy device. Moreover, the assembly includes an actuator assembly that moves the biopsy device relative to the housing from a first position to an extended position such that the biopsy device collects and cuts the anatomical tissue from the patient. The actuator assembly also retracts the biopsy device relative to the housing toward a retracted position. Furthermore, the assembly includes an ejection device that ejects the hemostatic agent from the biopsy device as the actuator assembly retracts the biopsy device toward the retracted position.

Abstract translation: 活检装置组件对患者的解剖组织进行活组织检查。 活检装置组件包括外壳和活检装置，活检装置延伸出外壳并收集和切割来自患者的解剖组织。 活检装置组件还包括可移除地容纳在活检装置中的止血剂。 此外，该组件包括致动器组件，该致动器组件将活检装置相对于壳体从第一位置移动到延伸位置，使得活检装置从患者收集和切割解剖组织。 致动器组件还使活检装置相对于壳体朝缩回位置缩回。 此外，该组件包括弹出装置，当致动器组件将活检装置朝缩回位置缩回时，弹出装置从活检装置弹出止血剂。

公开(公告)号：WO2008057478A2

公开(公告)日：2008-05-15

申请号：PCT/US2007/023246

申请日：2007-10-31

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  WEITZEL, William, F. ,  GIANCHANDANI, Yogesh, B.

Inventor： WEITZEL, William, F. ,  GIANCHANDANI, Yogesh, B.

IPC: A61M1/36

CPC classification number: A61M1/3639 ,  A61B5/02152 ,  A61B5/026 ,  A61M1/16 ,  A61M1/36 ,  A61M1/3607 ,  A61M1/3655 ,  A61M1/3656 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3375

Abstract: The present invention provides a system for determining blood flow rate in a vessel which communicates blood between two locations of a patient, the system comprising: a conduit in fluid communication with the vessel; at least one sensor in communication with the vessel for determining differential blood pressure (? P) between two or more locations within the vessel; and a processor operably connected to the at least one sensor for processing the ? P to obtain blood flow rate within the vessel. A method for determining blood flow rate in a vessel which communicates blood between two locations of a patient, the method comprising: diverting blood from the vessel at a diversion point to obtain a flow of diverted blood in a conduit; determining differential blood pressure (? P) of the diverted blood through the conduit; and processing the ? P to obtain blood flow rate within the vessel.

Abstract translation: 本发明提供了一种用于确定在患者的两个位置之间传送血液的血管中的血液流速的系统，所述系统包括：与血管流体连通的导管; 与血管连通的至少一个传感器，用于确定血管内两个或多个位置之间的差异血压（ΔP）; 以及可操作地连接到所述至少一个传感器的处理器， P以获得血管内血流量。 一种用于确定在患者的两个位置之间传送血液的血管中的血液流速的方法，所述方法包括：在转移点处从血管转移血液以获得导管中转向的血液的流动; 通过导管确定转移的血液的差异血压（ΔP）; 并处理？ P以获得血管内血流量。

公开(公告)号：WO2008042409A2

公开(公告)日：2008-04-10

申请号：PCT/US2007/021244

申请日：2007-10-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  KIM, Kang ,  WEITZEL, William, F. ,  RUBIN, Jonathan, M. ,  JIA, Congxian ,  O'DONNELL, Matthew ,  KOLIAS, Theodore, J.

Inventor： KIM, Kang ,  WEITZEL, William, F. ,  RUBIN, Jonathan, M. ,  JIA, Congxian ,  O'DONNELL, Matthew ,  KOLIAS, Theodore, J.

IPC: A61B8/00

CPC classification number: A61B5/0285 ,  A61B8/06 ,  A61B8/08 ,  A61B8/485 ,  G01S7/52036 ,  G01S7/52042

Abstract: An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.

Abstract translation: 优化的弹性模量重建程序可以从壁内应变和脉搏波速度（PWV）测量中估计血管壁的非线性弹性特性。 使用非侵入性自由手超声扫描程序来施加外力，与测量受试者血压的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 PWV估计在测量壁内应变的相同位置。 重建的弹性模量被优化，并且可以使用简单的双弹性模量重建程序来确定和监测动脉弹性模量。

公开(公告)号：WO2010065736A3

公开(公告)日：2010-09-23

申请号：PCT/US2009066578

申请日：2009-12-03

Applicant: UNIV MICHIGAN ,  WEITZEL WILLIAM F ,  KIRKPATRICK ANNE E ,  THOMPSON DAVID A ,  ADDIS TODD ,  WELCH CHRISTOPHER M ,  KRUGER GRANT H ,  WONG PHILIP M ,  RAO PANDURANGA S

Inventor： WEITZEL WILLIAM F ,  KIRKPATRICK ANNE E ,  THOMPSON DAVID A ,  ADDIS TODD ,  WELCH CHRISTOPHER M ,  KRUGER GRANT H ,  WONG PHILIP M ,  RAO PANDURANGA S

IPC: A61B10/02 ,  A61B17/32 ,  A61M31/00

CPC classification number: A61B10/0275 ,  A61B17/0057 ,  A61B2010/0208 ,  A61B2017/00654

Abstract: A biopsy device assembly performs a biopsy of an anatomical tissue of a patient. The biopsy device assembly includes a housing and a biopsy device that extends out of the housing and that collects and cuts anatomical tissue from the patient. The biopsy device assembly further includes a hemostatic agent removably housed in the biopsy device. Moreover, the assembly includes an actuator assembly that moves the biopsy device relative to the housing from a first position to an extended position such that the biopsy device collects and cuts the anatomical tissue from the patient. The actuator assembly also retracts the biopsy device relative to the housing toward a retracted position. Furthermore, the assembly includes an ejection device that ejects the hemostatic agent from the biopsy device as the actuator assembly retracts the biopsy device toward the retracted position.

Abstract translation: 活检装置组件执行患者的解剖组织的活组织检查。 活检装置组件包括壳体和活检装置，其延伸出壳体并且从患者收集和切割解剖组织。 活检装置组件还包括可移除地容纳在活检装置中的止血剂。 此外，组件包括致动器组件，其将活检装置相对于壳体从第一位置移动到延伸位置，使得活检装置从患者收集和切割解剖组织。 致动器组件还使活检装置相对于壳体朝向缩回位置缩回。 此外，该组件包括一个喷射装置，当致动器组件将活组织检查装置缩回到缩回位置时，其从活检装置喷射止血剂。

公开(公告)号：WO2008057478A3

公开(公告)日：2008-07-17

申请号：PCT/US2007023246

申请日：2007-10-31

Applicant: UNIV MICHIGAN ,  WEITZEL WILLIAM F ,  GIANCHANDANI YOGESH B

Inventor： WEITZEL WILLIAM F ,  GIANCHANDANI YOGESH B

IPC: A61M1/16 ,  A61M1/36

CPC classification number: A61M1/3639 ,  A61B5/02152 ,  A61B5/026 ,  A61M1/16 ,  A61M1/36 ,  A61M1/3607 ,  A61M1/3655 ,  A61M1/3656 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3375

Abstract: The present invention provides a system for determining blood flow rate in a vessel which communicates blood between two locations of a patient, the system comprising: a conduit in fluid communication with the vessel; at least one sensor in communication with the vessel for determining differential blood pressure (? P) between two or more locations within the vessel; and a processor operably connected to the at least one sensor for processing the ? P to obtain blood flow rate within the vessel. A method for determining blood flow rate in a vessel which communicates blood between two locations of a patient, the method comprising: diverting blood from the vessel at a diversion point to obtain a flow of diverted blood in a conduit; determining differential blood pressure (? P) of the diverted blood through the conduit; and processing the ? P to obtain blood flow rate within the vessel.

Abstract translation: 本发明提供了一种用于确定在患者的两个位置之间传送血液的血管中的血液流速的系统，所述系统包括：与血管流体连通的导管; 与血管连通的至少一个传感器，用于确定血管内两个或多个位置之间的差异血压（ΔP）; 以及可操作地连接到所述至少一个传感器的处理器， P以获得血管内血流量。 一种用于确定在患者的两个位置之间传送血液的血管中的血液流速的方法，所述方法包括：在转移点处从血管转移血液以获得导管中转向的血液的流动; 通过导管确定转移的血液的差异血压（ΔP）; 并处理？ P以获得血管内血流量。

公开(公告)号：WO2008042409A3

公开(公告)日：2008-06-05

申请号：PCT/US2007021244

申请日：2007-10-03

Applicant: UNIV MICHIGAN ,  KIM KANG ,  WEITZEL WILLIAM F ,  RUBIN JONATHAN M ,  JIA CONGXIAN ,  O'DONNELL MATTHEW ,  KOLIAS THEODORE J

Inventor： KIM KANG ,  WEITZEL WILLIAM F ,  RUBIN JONATHAN M ,  JIA CONGXIAN ,  O'DONNELL MATTHEW ,  KOLIAS THEODORE J

IPC: A61B8/06

CPC classification number: A61B5/0285 ,  A61B8/06 ,  A61B8/08 ,  A61B8/485 ,  G01S7/52036 ,  G01S7/52042

Abstract: An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.

Abstract translation: 优化的弹性模量重建程序可以从壁内应变和脉搏波速度（PWV）测量来估计血管壁的非线性弹性特性。 使用非侵入式无手超声扫描程序来施加外力，与测量受试者血压时的力相当，通过平衡内部动脉基线压力来实现更高的应变。 PWV估计在测量壁内应变的相同位置。 重建的弹性模量被优化，并且可以使用简单的双弹性模量重建程序来确定和监测动脉弹性模量。