公开(公告)号：WO2012031609A1

公开(公告)日：2012-03-15

申请号：PCT/EP2010/005482

申请日：2010-09-07

Applicant: JOHANNES KEPLER UNIVERSITÄT LINZ ,  TEASDALE, Ian, P. ,  WILFERT, Sandra ,  NISCHANG, Ivo ,  BRÜGGEMANN, Oliver

Inventor： TEASDALE, Ian, P. ,  WILFERT, Sandra ,  NISCHANG, Ivo ,  BRÜGGEMANN, Oliver

IPC: A61K47/48 ,  A61P35/00

CPC classification number: A61K47/34 ,  A61K31/337 ,  A61K31/4985 ,  A61K31/704 ,  A61K47/551 ,  A61K47/60 ,  A61K47/605

Abstract: The present invention relates in general to the field of targeted drug delivery of anti-cancer drugs. More precisely, the present invention concerns polymer drug conjugates, namely, conjugates of poly(organo)phosphazenes and anti-cancer drugs, wherein the conjugates are suitable to selectively release anti-cancer drugs in tumor tissue. In addition, the present invention relates to a method for manufacturing such poly(organo)phosphazene molecule conjugates, to poly(organo)phosphazene molecule conjugates for use in medicine, in particular, to poly(organo)phosphazene molecule conjugates for use in the treatment of cancer, and to pharmaceutical compositions comprising such poly(organo)phosphazene molecule conjugates.

Abstract translation: 本发明一般涉及抗癌药物的靶向药物递送领域。 更准确地说，本发明涉及聚合物药物共轭物，即聚（有机）磷腈和抗癌药物的缀合物，其中缀合物适于在肿瘤组织中选择性释放抗癌药物。 另外，本发明涉及制造这种聚（有机）磷腈分子缀合物的方法，用于医药中使用的聚（有机）磷腈分子共轭物，特别是涉及用于治疗的聚（有机）磷腈分子缀合物 的癌症，以及包含这种聚（有机）磷腈分子缀合物的药物组合物。