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公开(公告)号：WO2019140128A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/013104
申请日：2019-01-10
Applicant: SONY CORPORATION , SONY CORPORATION OF AMERICA
Inventor： MATRAY, Tracy
IPC: A61K47/60
CPC classification number: A61K47/605
Abstract: Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I) or a stereoisomer, tautomer or salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , L, L 1 , L 2 , L 3 , M, m and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.
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公开(公告)号：WO2019118714A1
公开(公告)日：2019-06-20
申请号：PCT/US2018/065432
申请日：2018-12-13
Applicant: SONY CORPORATION , SONY CORPORATION OF AMERICA
Inventor： MATRAY, Tracy
CPC classification number: A61K47/605 , A61K47/58 , A61K47/593 , A61K47/595 , C07F9/09 , C08F220/34 , C08G79/04 , C08L85/02
Abstract: Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): structure (I) or a stereoisomer, tautomer or salt thereof, wherein R 1 , R 2 , R 3 , L, L 1 , L 2 , L 3 , L 4 , M and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
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3.发明申请CURCUMIN-CONTAINING POLYMERS AND WATER SOLUBLE CURCUMIN DERIVATIVES AS PRODRUGS OR PRODRUG CARRIERS 审中-公开含有光泽聚合物和水溶性光泽度衍生物作为PRODRUGS或PRODRUG载体
公开(公告)号：WO2010033692A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057303
申请日：2009-09-17
Applicant: UNIVERSITY OF WYOMING , SHEN, Youqing , TANG, Huadong , VAN KIRK, Edward , MURDOCH, William , RADOSZ, Maciej
Inventor： SHEN, Youqing , TANG, Huadong , VAN KIRK, Edward , MURDOCH, William , RADOSZ, Maciej
IPC: A01N43/20 , A01N43/24 , A61K31/335
CPC classification number: A61K31/335 , A61K9/1273 , A61K9/5146 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/605
Abstract: Curcumin, a polyphenol extracted from the rhizome turmeric, has been polymerized to produce a polymer material having a backbone of one or more repeating structural units, at least one of which comprises a curcumin monomer residue. These curcumin-containing polymers have a wide range of pharmacological activities, including, among others antitumor, antioxidant, antiinflammatory, antithrombotic and antibacterial activities. Certain species of these polymers have exhibited remarkable antitumor activity. Water-soluble curcumin derivatives and their use as prodrugs and prodrug carriers are also disclosed.
Abstract translation: 姜黄素是从根茎姜黄提取的多酚，已被聚合以制备具有一个或多个重复结构单元的主链的聚合物材料，其中至少一个包含姜黄素单体残基。 这些含姜黄素的聚合物具有广泛的药理活性，包括抗肿瘤，抗氧化，抗炎，抗血栓和抗菌活性等。 这些聚合物的某些物质已经表现出显着的抗肿瘤活性。 还公开了水溶性姜黄素衍生物及其作为前药和前药载体的用途。
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4.发明申请2',5' PHOSPHOROTHIOATE/PHOSPHODIESTER OLIGOADENYLATES AND ANTIVIRAL USES THEREOF 审中-公开2'，5'磷酸/磷酸二乙酯和其抗病毒用途
公开(公告)号：WO1996008256A1
公开(公告)日：1996-03-21
申请号：PCT/US1995010683
申请日：1995-08-22
Inventor： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , SUHADOLNIK, Robert, F. , PFLEIDERER, Wolfgang
IPC: A61K31/70
CPC classification number: C07H21/00 , A61K47/59 , A61K47/605 , Y10S514/885 , Y10S514/889 , Y10S514/934
Abstract: Optically active antiviral compounds having formula (I), wherein m is 0, 1, 2 or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; R, R1 and R2 are independently of each other selected from the group consisting of oxygen and sulfur, provided that all R, R1 and R2, may not be oxygen, and further provided that all R, R1, and R2 may not be sulfur. The compounds possess increased antiviral activity and/or metabolic stability.
Abstract translation: 具有式（I）的光学活性抗病毒化合物，其中m为0,1,2或3; n和q选自0和1组，条件是n和q不能都为零; R，R 1和R 2彼此独立地选自氧和硫，条件是所有R 1，R 2和R 2可以不是氧，并且进一步规定所有R 1，R 2和R 2可以不是硫。 该化合物具有增加的抗病毒活性和/或代谢稳定性。
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公开(公告)号：WO2019071208A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/054725
申请日：2018-10-05
Applicant: SONY CORPORATION , SONY CORPORATION OF AMERICA
Inventor： MATRAY, Tracy , SINGH, Sharat , BATTRELL, C., Frederick , VANBRUNT, Michael
CPC classification number: A61K47/60 , A61K47/605 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6883 , A61K49/0021 , A61K49/0043 , A61K49/0054 , A61P29/00 , A61P31/00 , A61P35/00 , C07F9/00 , C07F9/2408 , C08G79/00 , C08G79/04
Abstract: Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R 1 , R 2 , R 3 , L, L 1 , L 2 , L 3 , M and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.
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Patent Agency Ranking6.发明申请BIODEGRADABLE, WATER SOLUBLE AND PH RESPONSIVE POLY(ORGANO)PHOSPHAZENES 审中-公开可生物降解，水溶性和PH响应聚（有机酸）磷酸盐
公开(公告)号：WO2012031609A1
公开(公告)日：2012-03-15
申请号：PCT/EP2010/005482
申请日：2010-09-07
Applicant: JOHANNES KEPLER UNIVERSITÄT LINZ , TEASDALE, Ian, P. , WILFERT, Sandra , NISCHANG, Ivo , BRÜGGEMANN, Oliver
Inventor： TEASDALE, Ian, P. , WILFERT, Sandra , NISCHANG, Ivo , BRÜGGEMANN, Oliver
CPC classification number: A61K47/34 , A61K31/337 , A61K31/4985 , A61K31/704 , A61K47/551 , A61K47/60 , A61K47/605
Abstract: The present invention relates in general to the field of targeted drug delivery of anti-cancer drugs. More precisely, the present invention concerns polymer drug conjugates, namely, conjugates of poly(organo)phosphazenes and anti-cancer drugs, wherein the conjugates are suitable to selectively release anti-cancer drugs in tumor tissue. In addition, the present invention relates to a method for manufacturing such poly(organo)phosphazene molecule conjugates, to poly(organo)phosphazene molecule conjugates for use in medicine, in particular, to poly(organo)phosphazene molecule conjugates for use in the treatment of cancer, and to pharmaceutical compositions comprising such poly(organo)phosphazene molecule conjugates.
Abstract translation: 本发明一般涉及抗癌药物的靶向药物递送领域。 更准确地说，本发明涉及聚合物药物共轭物，即聚（有机）磷腈和抗癌药物的缀合物，其中缀合物适于在肿瘤组织中选择性释放抗癌药物。 另外，本发明涉及制造这种聚（有机）磷腈分子缀合物的方法，用于医药中使用的聚（有机）磷腈分子共轭物，特别是涉及用于治疗的聚（有机）磷腈分子缀合物 的癌症，以及包含这种聚（有机）磷腈分子缀合物的药物组合物。
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公开(公告)号：WO2008089258A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/051196
申请日：2008-01-16
Applicant: CAPPELLA, INC. , RANADE, Shrirang , STECKEL, Mark , OHRI, Rachit
Inventor： RANADE, Shrirang , STECKEL, Mark , OHRI, Rachit
IPC: A61K47/48
CPC classification number: A61K47/6957 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/605 , A61K47/62
Abstract: Disclosed herein are coatings for implantable medical device. The coatings comprise a biodegradable polymer linked to a chemical moiety through a covalent bond, wherein the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond.
Abstract translation: 本文公开了用于可植入医疗装置的涂层。 涂层包含通过共价键与化学部分连接的可生物降解的聚合物，其中化学部分在共价键降解时形成药物活性剂。
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8.发明申请DRUG ELUTING MEDICAL DEVICE USING POLYMERIC THERAPEUTICS WITH TRANSGLUTAMINASE SUBSTRATES 审中-公开使用聚氨酯酶底物的聚合物治疗药物给药医疗器械
公开(公告)号：WO2008089257A2
公开(公告)日：2008-07-24
申请号：PCT/US2008051195
申请日：2008-01-16
Applicant: CAPPELLA INC , RANADE SHRIRANG , STECKEL MARK , OHRI RACHIT
Inventor： RANADE SHRIRANG , STECKEL MARK , OHRI RACHIT
IPC: A61K47/48
CPC classification number: A61K47/6957 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/605 , A61K47/62
Abstract: Disclosed herein are coatings for implantable medical device. The coatings comprise a composition, comprising a polymer linked to a chemical moiety through a covalent bond, wherein the chemical moiety forms a pharmaceutically active agent upon degradation (e.g., hydrolysis) of the covalent bond; and transglutaminase substrates.
Abstract translation: 本文公开了用于可植入医疗装置的涂层。 涂层包含组合物，其包含通过共价键与化学部分连接的聚合物，其中所述化学部分在共价键降解（例如水解）时形成药物活性剂; 和转谷氨酰胺酶底物。
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9.发明申请COMPOSITIONS FOR RELEASE OF RADIOSENSITIZERS, AND METHODS OF MAKING AND USING THE SAME 审中-公开释放放射增敏剂的组合物及其制备方法和使用方法
公开(公告)号：WO02030472A2
公开(公告)日：2002-04-18
申请号：PCT/US2001/031817
申请日：2001-10-12
CPC classification number: A61K41/0038 , A61K9/1641 , A61K9/1647 , A61K9/7007 , A61K47/593 , A61K47/605
Abstract: The present invention relates to compositions comprising a biocompatible polymer with phosphorous linkages and a radiosensitizer, and methods of making and using the same.
Abstract translation: 本发明涉及包含具有磷键的生物相容性聚合物和放射增敏剂的组合物及其制备和使用方法。
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公开(公告)号：WO2019140227A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/013242
申请日：2019-01-11
Applicant: SONY CORPORATION , SONY CORPORATION OF AMERICA
Inventor： MATRAY, Tracy
CPC classification number: A61K47/605 , A61K47/544 , A61K47/549 , A61P35/00
Abstract: Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , L, L 1 , L 2 , L 3 , L 4 , M, q, w and n are as defined herein. Methods associated with preparation and use of such compounds is also provided.
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