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1.发明申请THERAPEUTIC COMBINATION OF A PANHER/VEGFR2 KINASE INHIBITOR AND A PLATINUM COMPOUND 审中-公开PANHER / VEGFR2激酶抑制剂和白蛋白化合物的治疗组合
公开(公告)号：WO2008057863A1
公开(公告)日：2008-05-15
申请号：PCT/US2007/083095
申请日：2007-10-31
IPC分类号： A61K31/53 , A61K31/555 , A61K33/24 , A61P35/00
CPC分类号： A61K31/555 , A61K31/53 , A61K33/24 , A61K2300/00
摘要： This invention relates to a synergistic therapeutic combination of anti-cancer compounds which comprises a) a panHER/VEGFR2 kinase inhibitor, and b) a platinum compound, and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use. The invention also relates to treating certain cancers utilizing the combination of the invention.
摘要翻译： 本发明涉及抗癌化合物的协同治疗组合，其包括a）panHER / VEGFR2激酶抑制剂，和b）铂化合物，以及任选的至少一种用于同时，分开或顺序使用的药学上可接受的载体。 本发明还涉及利用本发明的组合治疗某些癌症。
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公开(公告)号：WO2005012875A3
公开(公告)日：2007-03-15
申请号：PCT/US2004024424
申请日：2004-07-29
申请人： SQUIBB BRISTOL MYERS CO , LI MARTHA , RUPNOW BRENT A , WEBSTER KEVIN R , JACKSON DONALD G , WONG TAI W
发明人： LI MARTHA , RUPNOW BRENT A , WEBSTER KEVIN R , JACKSON DONALD G , WONG TAI W
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , G01N20060101
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/106 , C12Q2600/16 , G01N2333/4739
摘要： Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates cdk activity.
摘要翻译： 具有与细胞对一种或多种cdk调节剂治疗反应相关的表达模式的生物标志物及其用途。 还提供了用于测试或预测哺乳动物是否会治疗性治疗癌症的方法的方法，所述方法包括施用调节cdk活性的药剂。
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公开(公告)号：WO2006004833A3
公开(公告)日：2006-01-12
申请号：PCT/US2005/023099
申请日：2005-06-28
申请人： BRISTOL-MYERS SQUIBB COMPANY , BORZILLERI, Robert, M. , CHEN, Zhong , HUNT, John, T. , HUYNH, Tram, N. , POSS, Michael, A. , SCHROEDER, Gretchen, M. , VACCARO, Wayne , WONG, Tai, W. , CHEN, Xiao Tao , KIM, Kyoung, S.
发明人： BORZILLERI, Robert, M. , CHEN, Zhong , HUNT, John, T. , HUYNH, Tram, N. , POSS, Michael, A. , SCHROEDER, Gretchen, M. , VACCARO, Wayne , WONG, Tai, W. , CHEN, Xiao Tao , KIM, Kyoung, S.
IPC分类号： A61K31/53 , C07D487/04 , C07D253/10 , A61P19/02 , A61P35/00
摘要： In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
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公开(公告)号：WO2006004833A2
公开(公告)日：2006-01-12
申请号：PCT/US2005023099
申请日：2005-06-28
申请人： SQUIBB BRISTOL MYERS CO , BORZILLERI ROBERT M , CHEN ZHONG , HUNT JOHN T , HUYNH TRAM N , POSS MICHAEL A , SCHROEDER GRETCHEN M , VACCARO WAYNE , WONG TAI W , CHEN XIAO TAO , KIM KYOUNG S
发明人： BORZILLERI ROBERT M , CHEN ZHONG , HUNT JOHN T , HUYNH TRAM N , POSS MICHAEL A , SCHROEDER GRETCHEN M , VACCARO WAYNE , WONG TAI W , CHEN XIAO TAO , KIM KYOUNG S
IPC分类号： A61K31/53 , A61K31/519 , A61K31/52 , C07D471/04 , C07D473/14 , C07D487/02 , C07D487/04 , C07D495/04
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
摘要： In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
摘要翻译： 通常，本发明包括式I和II化合物，包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其他蛋白激酶介导的疾病。
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公开(公告)号：WO2005012875A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024424
申请日：2004-07-29
申请人： BRISTOL-MYERS SQUIBB COMPANY , LI, Martha , RUPNOW, Brent, A. , WEBSTER, Kevin, R. , JACKSON, Donald, G. , WONG, Tai, W.
IPC分类号： G01N
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/106 , C12Q2600/16 , G01N2333/4739
摘要： Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates cdk activity.
摘要翻译： 具有与细胞对一种或多种cdk调节剂治疗反应相关的表达模式的生物标志物及其用途。 还提供了用于测试或预测哺乳动物是否会治疗性治疗癌症的方法的方法，所述方法包括施用调节cdk活性的药剂。
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6.发明申请TRANSGENIC NON-HUMAN MAMMALS EXPRESSING CONSTITUTIVELY ACTIVATED TYROSINE KINASE RECEPTORS 审中-公开表达一般激活的酪氨酸激酶受体的转基因非人类哺乳动物
公开(公告)号：WO2003073841A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/008278
申请日：2003-03-03
申请人： BRISTOL-MYERS SQUIBB COMPANY , BOL, David, K. , CARBONI, Joan, M. , ROWLEY, Ronald, B. , WONG, Tai, W. , LEE, Francis, Y.
IPC分类号： A01K
CPC分类号： C07K14/72 , A01K67/0271 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0331 , C07K2319/70 , C12N15/8509 , C12N2517/02
摘要： A transgenic non-human mammal whose germ cells and somatic cells contain a constitutively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-independent in vivo models for the identification and development of selective tyrosine kinase modulators for the treatment of cancer.
摘要翻译： 在胚胎期，其生殖细胞和体细胞含有引入哺乳动物或哺乳动物祖先的组成型激活的酪氨酸激酶受体的转基因非人哺乳动物。 转基因非人哺乳动物可以用作体内独立体内模型，用于鉴定和开发用于治疗癌症的选择性酪氨酸激酶调节剂。
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7.发明申请
公开(公告)号：WO2003073841A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/008278
申请日：2003-03-03
申请人： BRISTOL-MYERS SQUIBB COMPANY , BOL, David, K. , CARBONI, Joan, M. , ROWLEY, Ronald, B. , WONG, Tai, W. , LEE, Francis, Y.
IPC分类号： A01K67/027
摘要： A transgenic non-human mammal whose germ cells and somatic cells contain a constitutively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-independent in vivo models for the identification and development of selective tyrosine kinase modulators for the treatment of cancer.
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