公开(公告)号：WO2005023678A1

公开(公告)日：2005-03-17

申请号：PCT/GB2004/003864

申请日：2004-09-09

Applicant: BTG INTERNATIONAL LIMITED ,  HARMAN, Anthony, David ,  WRIGHT, David, Dakin, Iowerth ,  MIJERS, Jam, Willem, Marinus ,  KAY, Stuart, Brian, William ,  HURLSTONE, Christopher, John ,  DIXON, Julina, Richard ,  POCOCK, Andrew, Gordon ,  HOGAN, Brendan

Inventor： HARMAN, Anthony, David ,  WRIGHT, David, Dakin, Iowerth ,  MIJERS, Jam, Willem, Marinus ,  KAY, Stuart, Brian, William ,  HURLSTONE, Christopher, John ,  DIXON, Julina, Richard ,  POCOCK, Andrew, Gordon ,  HOGAN, Brendan

IPC: B65D83/16

CPC classification number: B65D83/205 ,  B65B3/22 ,  B65D83/7532 ,  B65D83/756

Abstract: A foam transfer device (600) is described, for use with aerosol canister apparatus for producing a sclerosant foam for the treatment of, inter alia, varicose veins. The device enables diversion of an initial quantity of below-specification foam from the canister to waste, e.g. to an integral waste chamber, before dispensing a further quantity of foam for use in treatment. The switching of the flow from the waste chamber to a different outlet (618) for use is accomplished without interrupting the flow from the aerosol canister since this would cause the foam to drop below specification again. The waste chamber may be transparent so that the foam entering it can be observed and a decision made by a user when to stop diverting foam to waste. Alternatively, the foam may be diverted automatically e.g. when a set time has elapsed or a set volume of foam dispensed. The foam for use is normally dispensed into a syringe for subsequent injection into a varicose vein of a patient.

Abstract translation: 描述了泡沫转移装置（600），用于气溶胶罐装置，用于产生用于治疗静脉曲张的硬化泡沫。 该装置能够将来自罐的初始数量低于规格的泡沫转移到废物，例如。 在分配更多量的泡沫以用于治疗之前，到整体的废物室。 在不中断来自气溶胶罐的流动的情况下，实现从废物室到不同出口（618）的流动切换，因为这将导致泡沫再次下降到规格以下。 废物室可以是透明的，使得可以观察到进入其中的泡沫，并且由用户决定何时停止将泡沫转移到废物中。 或者，泡沫可以自动转移，例如 当设定的时间过去或一定量的泡沫分配时。 使用的泡沫通常分配到注射器中，以便随后注射到患者的静脉曲张静脉中。

公开(公告)号：WO2005048983A1

公开(公告)日：2005-06-02

申请号：PCT/GB2004/004824

申请日：2004-11-17

Applicant: BTG INTERNATIONAL LIMITED ,  WRIGHT, David, Dakin, Iowerth ,  HARMAN, Anthony, David ,  ROBINSON, Nikki ,  HODGES, Garry ,  KADAR, Adil

Inventor： WRIGHT, David, Dakin, Iowerth ,  HARMAN, Anthony, David ,  ROBINSON, Nikki ,  HODGES, Garry ,  KADAR, Adil

IPC: A61K9/12

CPC classification number: B65B3/003 ,  A61B17/00008 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12186 ,  A61B2017/00495 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/122 ,  A61K9/124 ,  A61K31/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61M5/178 ,  A61M5/19 ,  A61M16/00 ,  A61M2202/00 ,  A61M2210/086 ,  A61M2210/12 ,  B01F3/04446 ,  B01F5/0685 ,  B01F5/0693 ,  B01F13/0023 ,  B65B31/00 ,  Y10S514/945

Abstract: Present application discloses a device for generating and dispensing a foam for therapeutic use comprising a) a housing, b) a first chamber with gas at a substantially atmospheric pressure, a second chamber with at least one sclerosant agent c) an outlet for dispensing gas and the solution in the form of a foam d) the flow path for mixing the gas and the solution e) a foaming unit.

Abstract translation: 本申请公开了一种用于产生和分配用于治疗用途的泡沫的装置，包括：a）壳体，b）具有基本上大气压的气体的第一室，具有至少一种硬化剂的第二室; c）用于分配气体的出口和 以泡沫形式的溶液d）用于混合气体和溶液的流动路径e）发泡单元。

公开(公告)号：WO2005023678A8

公开(公告)日：2006-01-19

申请号：PCT/GB2004003864

申请日：2004-09-09

Applicant: BTG INT LTD ,  HARMAN ANTHONY DAVID ,  WRIGHT DAVID DAKIN IOWERTH ,  MIJERS JAM WILLEM MARINUS ,  KAY STUART BRIAN WILLIAM ,  HURLSTONE CHRISTOPHER JOHN ,  DIXON JULIAN RICHARD ,  POCOCK ANDREW GORDON ,  HOGAN BRENDAN

Inventor： HARMAN ANTHONY DAVID ,  WRIGHT DAVID DAKIN IOWERTH ,  MIJERS JAM WILLEM MARINUS ,  KAY STUART BRIAN WILLIAM ,  HURLSTONE CHRISTOPHER JOHN ,  DIXON JULIAN RICHARD ,  POCOCK ANDREW GORDON ,  HOGAN BRENDAN

IPC: B65D83/16

CPC classification number: B65D83/205 ,  B65B3/22 ,  B65D83/7532 ,  B65D83/756

Abstract: A foam transfer device (600) is described, for use with aerosol canister apparatus for producing a sclerosant foam for the treatment of, inter alia, varicose veins. The device enables diversion of an initial quantity of below-specification foam from the canister to waste, e.g. to an integral waste chamber, before dispensing a further quantity of foam for use in treatment. The switching of the flow from the waste chamber to a different outlet (618) for use is accomplished without interrupting the flow from the aerosol canister since this would cause the foam to drop below specification again. The waste chamber may be transparent so that the foam entering it can be observed and a decision made by a user when to stop diverting foam to waste. Alternatively, the foam may be diverted automatically e.g. when a set time has elapsed or a set volume of foam dispensed. The foam for use is normally dispensed into a syringe for subsequent injection into a varicose vein of a patient.

Abstract translation: 描述了泡沫转移装置（600），用于气溶胶罐装置，用于产生用于治疗静脉曲张的硬化泡沫。 该装置能够将来自罐的初始数量低于规格的泡沫转移到废物，例如， 在分配更多量的泡沫以用于治疗之前，到整体的废物室。 在不中断来自气溶胶罐的流动的情况下，实现从废物室到不同出口（618）的流动切换，因为这将导致泡沫再次下降到规格以下。 废物室可以是透明的，使得可以观察到进入其中的泡沫，并且由用户决定何时停止将泡沫转移到废物中。 或者，泡沫可以自动转移，例如 当设定的时间过去或一定量的泡沫分配时。 使用的泡沫通常分配到注射器中，以便随后注射到患者的静脉曲张静脉中。

公开(公告)号：WO2005048984A1

公开(公告)日：2005-06-02

申请号：PCT/GB2004/004846

申请日：2004-11-17

Applicant: BTG INTERNATIONAL LIMITED ,  WRIGHT, David, Dakin, Iowerth ,  HARMAN, Anthony, David ,  ROBINSON, Nikki ,  HODGES, Garry ,  KADAR, Adil

Inventor： WRIGHT, David, Dakin, Iowerth ,  HARMAN, Anthony, David ,  ROBINSON, Nikki ,  HODGES, Garry ,  KADAR, Adil

IPC: A61K9/12

CPC classification number: B65B3/003 ,  A61B17/00008 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12186 ,  A61B2017/00495 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/122 ,  A61K9/124 ,  A61K31/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61M5/178 ,  A61M5/19 ,  A61M16/00 ,  A61M2202/00 ,  A61M2210/086 ,  A61M2210/12 ,  B01F3/04446 ,  B01F5/0685 ,  B01F5/0693 ,  B01F13/0023 ,  B65B31/00 ,  Y10S514/945

Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternativelt, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.

Abstract translation: 用于治疗静脉曲张的治疗性泡沫包括用诸如二氧化碳，氧气或其混合物的生理气体发泡的硬化溶液。 泡沫的氮含量小于0.8％。 可以使用包含微米尺寸的精细网格的加压罐系统产生气体和硬化液体通过该微孔尺寸来制造泡沫。 替代方案，泡沫可以通过在两个注射器之间通过细网络传递气体和溶液而产生。 描述了用于最小化基于罐或注射器的产品中氮的量的技术。 还公开了一种使用基于注射器的装置同时产生和递送泡沫的技术。

公开(公告)号：WO2005048977A2

公开(公告)日：2005-06-02

申请号：PCT/GB2004/004848

申请日：2004-11-17

Applicant: BTG INTERNATIONAL LIMITED ,  WRIGHT, David, Dakin, Iowerth ,  HARMAN, Anthony, David ,  ROBINSON, Nikki ,  HODGES, Garry ,  KADAR, Adil

Inventor： WRIGHT, David, Dakin, Iowerth ,  HARMAN, Anthony, David ,  ROBINSON, Nikki ,  HODGES, Garry ,  KADAR, Adil

IPC: A61K9/00

CPC classification number: B65B3/003 ,  A61B17/00008 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12186 ,  A61B2017/00495 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/122 ,  A61K9/124 ,  A61K31/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61M5/178 ,  A61M5/19 ,  A61M16/00 ,  A61M2202/00 ,  A61M2210/086 ,  A61M2210/12 ,  B01F3/04446 ,  B01F5/0685 ,  B01F5/0693 ,  B01F13/0023 ,  B65B31/00 ,  Y10S514/945

Abstract: A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.

Abstract translation: 用于治疗静脉曲张的治疗性泡沫包括用诸如二氧化碳，氧气或其混合物的生理气体发泡的硬化溶液。 泡沫的氮含量小于0.8％。 可以使用包含微米尺寸的精细网格的加压罐系统产生气体和硬化液体通过该微孔尺寸来制造泡沫。 或者，泡沫可以通过气体和溶液在两个注射器之间通过细网而产生。 描述了用于最小化基于罐或注射器的产品中氮的量的技术。 还公开了一种使用基于注射器的装置同时产生和递送泡沫的技术。