公开(公告)号：WO2008121076A1

公开(公告)日：2008-10-09

申请号：PCT/SG2007/000326

申请日：2007-09-28

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  MITSUI CHEMICALS INC. ,  SEAYAD, Abdul, Majeed ,  CHAI, Christina ,  RAMALINGAM, Balamurugan ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko

发明人： SEAYAD, Abdul, Majeed ,  CHAI, Christina ,  RAMALINGAM, Balamurugan ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko

IPC分类号： C07F7/00

CPC分类号： C07C253/30 ,  C07B41/02 ,  C07B43/08 ,  C07B53/00 ,  C07C255/19

摘要： The present invention relates to titanium catalysts for asymmetric synthesis reactions produced by bringing a reaction mixture obtained by contacting water and a titanium alkoxide into contact with an optically active ligand represented by the general formula (a), wherein R 1, R 2 , R 3 , and R 4 are independently a hydrogen atom, an alkyl group, or the like, and A* represents a group with two or more carbon atoms having an asymmetric carbon atom or axial asymmetry. The invention further relates to a process for asymmetric cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

摘要翻译： 本发明涉及用于不对称合成反应的钛催化剂，其通过使水与烷氧基钛接触而获得的反应混合物与由通式（a）表示的光学活性配体接触而制备，其中R 1， R 2，R 3，R 4和R 4独立地为氢原子，烷基等，A *表示 具有两个以上具有不对称碳原子或轴向不对称的碳原子的基团。 本发明还涉及亚胺不对称氰化方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。

公开(公告)号：WO2009041919A1

公开(公告)日：2009-04-02

申请号：PCT/SG2008/000367

申请日：2008-09-26

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  MITSUI CHEMICALS, INC. ,  SEAYAD, Abdul Majeed ,  RAMALINGAM, Balamurugan ,  CHAI, Christina ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko

发明人： SEAYAD, Abdul Majeed ,  RAMALINGAM, Balamurugan ,  CHAI, Christina ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko

IPC分类号： C07F7/28

CPC分类号： C07F7/006

摘要： The present invention relates to titanium catalysts for asymmetric synthesis reactions produced by bringing a reaction mixture obtained by contacting water and a titanium alkoxide into contact with an optically active ligand represented by the general formula (a), wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and A* represents a group with two or more carbon atoms having an asymmetric carbon atom or axial asymmetry. The invention further relates to a process for asymmetric cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

摘要翻译： 本发明涉及通过使水与钛醇盐接触而得到的反应混合物与通式（a）表示的光学活性配体接触而制备的不对称合成反应的钛催化剂，其中R1，R2，R3和R4 独立地为氢原子，烷基等，A *表示具有不对称碳原子或轴对称性的碳原子数为2以上的基团。 本发明还涉及亚胺不对称氰化方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。

公开(公告)号：WO2008121074A1

公开(公告)日：2008-10-09

申请号：PCT/SG2007/000084

申请日：2007-03-29

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  MITSUI CHEMICALS, INC. ,  YEO, Wee Chuan ,  CHAI, L. L. Christina ,  SELVARATNAM, Selvasothi ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko

发明人： YEO, Wee Chuan ,  CHAI, L. L. Christina ,  SELVARATNAM, Selvasothi ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko

IPC分类号： C07B53/00 ,  C07B43/08 ,  C07B41/02 ,  C07C253/00

CPC分类号： C07C253/30 ,  C07B41/02 ,  C07B43/08 ,  C07B53/00 ,  C07C255/19

摘要： The present invention relates to a method of producing an optically active cyanohydrin derivative, which comprises reacting an aldehyde or an asymmetrical ketone with a cyanating agent in the presence of a Lewis base and a titanium compound produced from a partial hydrolysate of titanium tetraalkoxide and an optically active ligand represented by formula (II) or a titanium oxoalkoxide compound represented by formula (I) [Ti x O y ](OR 1 ) 4x-2y , and an optically active ligand represented by formula (II), wherein R 1 is an optionally substituted alkyl group or an optionally substituted aryl group; x is an integer of not less than 2; y is an integer of not less than 1; and y/x satisfies 0.1 2 , R 3 and R 4 are independently a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aromatic heterocyclic group, an acyl group, an alkoxycarbonyl group or an aryloxycarbonyl group, each of which may be optionally substituent, two or more of R 2 , R 3 and R 4 may be linked together to form a ring, and the ring may have a substituent; and A represents a hydrocarbon containing group with three or more carbon atoms having an asymmetric carbon atom or axial asymmetry.

摘要翻译： 本发明涉及一种制备光学活性羟腈衍生物的方法，其包括在路易斯碱和由四烷氧基钛的部分水解产物和光学上产生的钛化合物存在下使醛或不对称酮与氰化剂反应 由式（II）表示的活性配体或由式（I）表示的氧钛氧烷化合物[Ti x O y O y]（OR 1） 4x-2y和由式（II）表示的光学活性配体，其中R 1是任选取代的烷基或任选取代的芳基; x是不小于2的整数; y是不小于1的整数; y / x满足0.1

公开(公告)号：WO2010093336A1

公开(公告)日：2010-08-19

申请号：PCT/SG2010/000052

申请日：2010-02-11

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  MITSUI CHEMICALS, INC. ,  SEAYAD, Abdul Majeed ,  RAMALINGAM, Balamurugan ,  CHAI, Christina ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko ,  WADAMOTO, Manabu

发明人： SEAYAD, Abdul Majeed ,  RAMALINGAM, Balamurugan ,  CHAI, Christina ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko ,  WADAMOTO, Manabu

IPC分类号： C07B43/08 ,  B01J31/18 ,  B01J31/22

CPC分类号： B01J31/1805 ,  B01J31/2265 ,  B01J2231/341 ,  B01J2531/46 ,  C07B43/08

摘要： The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R 1 , R 2 , R 3 , and R 4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

摘要翻译： 本发明涉及通过使包含钛醇盐和配体与水接触的反应混合物而制备的合成反应的钛催化剂，其中配体由通式（e）表示：其中R1，R2，R3和R4 独立地为氢原子，烷基等，（A）表示具有2个以上碳原子的基团。 钛催化剂可以以固体形式分离并且可以被储存。 本发明还涉及一种氰化氰胺的方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。

公开(公告)号：WO2010093327A1

公开(公告)日：2010-08-19

申请号：PCT/SG2009/000044

申请日：2009-02-11

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  MITSUI CHEMICALS, INC. ,  SEAYAD, Abdul Majeed ,  RAMALINGAM, Balamurugan ,  CHAI, Christina ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko ,  WADAMOTO, Manabu

发明人： SEAYAD, Abdul Majeed ,  RAMALINGAM, Balamurugan ,  CHAI, Christina ,  NAGATA, Takushi ,  YOSHINAGA, Kazuhiko ,  WADAMOTO, Manabu

IPC分类号： C07B43/08 ,  B01J31/18 ,  B01J31/22

CPC分类号： B01J31/1805 ,  B01J31/2265 ,  B01J2231/341 ,  B01J2531/46 ,  C07B43/08

摘要： The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e), wherein R 1 , R 2 , R 3 , and R 4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

摘要翻译： 本发明涉及通过使包含钛醇盐和配体与水接触的反应混合物而制备的合成反应的钛催化剂，其中配体由通式（e）表示，其中R1，R2，R3和R4 独立地为氢原子，烷基等，（A）表示具有2个以上碳原子的基团。 钛催化剂可以以固体形式分离并且可以被储存。 本发明还涉及亚胺氰化方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。