公开(公告)号：WO2015172101A1

公开(公告)日：2015-11-12

申请号：PCT/US2015/030017

申请日：2015-05-08

Applicant: 206 ORTHO, INC.

Inventor： D'AGOSTINO, Jeffrey, A. ,  WHITEHOUSE, Robert, S. ,  CARTER, Andrew, J. ,  WATTERSON, Arthur ,  LANE, Joseph, P. ,  MCRURY, Ian, D. ,  BEAUREGARD, Samantha ,  SEIL, Nikole ,  BLANK, Werner ,  HEGEDUS, Charles ,  AGARWAL, Sandip

IPC: A61B17/04

CPC classification number: A61L27/58 ,  A61B17/7097 ,  A61B17/72 ,  A61B17/7275 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61B2017/00933 ,  A61B2017/00938 ,  A61B2017/00964 ,  A61B2017/564 ,  A61F2/2846 ,  A61F2002/2835 ,  A61L27/446 ,  A61L27/46 ,  A61L27/48 ,  A61L27/50 ,  A61L2430/02

Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

Abstract translation: 一种复合材料，包括：阻挡层，所述屏障构造成选择性地通过水，并且所述屏障在水的存在下是可降解的; 用于配置在所述阻挡层内的基体材料，其中所述基体材料具有可流动状态和设定状态，并且其中所述基质材料在水存在下是可降解的; 和至少一个增强元件，用于配置在所述屏障内并与所述基体材料整合，其中所述至少一个增强元件在水的存在下是可降解的，并且其中，在所述至少一个增强元件在存在下降解时 的水，提供用于在水存在下调节所述基质材料的降解速率的试剂。

公开(公告)号：WO2019217748A1

公开(公告)日：2019-11-14

申请号：PCT/US2019/031617

申请日：2019-05-09

Applicant: 206 ORTHO, INC.

Inventor： D'AGOSTINO, Jeffrey A. ,  BLANK, Werner ,  HEGEDUS, Charles ,  AGARWAL, Sandip ,  NELSON, Elizabeth

IPC: A61B17/70 ,  A61B17/80 ,  A61L27/00 ,  A61F2/28

Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

公开(公告)号：WO2018089939A1

公开(公告)日：2018-05-17

申请号：PCT/US2017/061398

申请日：2017-11-13

Applicant: 206 ORTHO, INC.

Inventor： D'AGOSTINO, Jeffrey, A. ,  BLANK, Werner ,  HEGEDUS, Charles ,  AGARWAL, Sandip ,  NELSON, Elizabeth ,  WHITEHOUSE, Robert, S.

IPC: A61L27/00 ,  A61F2/28

Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

Abstract translation: 一种复合材料，其包含：屏障，所述屏障被配置为选择性地通过水，并且所述屏障在水存在下是可降解的; 用于置于所述屏障内的基质材料，其中所述基质材料具有可流动状态和凝固状态，并且其中所述基质材料在水存在下是可降解的; 以及至少一个加强元件，用于设置在所述屏障内并与所述基质材料结合，其中所述至少一个加强元件在水存在下是可降解的，并且其中，在所述至少一个加强元件降解 提供了一种调节所述基质材料在水存在下的降解速率的试剂。