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    CRANIOMAXILLOFACIAL BONE PLATE SIZERS AND TEMPLATES
    3.
    发明申请
    CRANIOMAXILLOFACIAL BONE PLATE SIZERS AND TEMPLATES 审中-公开
    非骨乳房面部骨板尺寸和模板

    公开(公告)号：WO2018085365A2

    公开(公告)日：2018-05-11

    申请号：PCT/US2017/059492

    申请日：2017-11-01

    Applicant: KLS-MARTIN, L.P.

    Inventor： JOHNSTON, Thomas, S., Jr. ,  PINTO, Jennifer ,  KOHLER, Klaus

    IPC: A61B17/80

    CPC classification number: A61B17/8061 ,  A61B17/688 ,  A61B17/80 ,  A61B17/8085 ,  A61B90/06 ,  A61B2017/564 ,  A61B2090/061 ,  A61L2430/02

    Abstract: One or more arrays of flexible, disposable, bone plate sizers with corresponding arrays of permanent bone plates, systems using these bone plate sizers and/or templates, and methodologies using these bone plate sizers and/or templates are embodied. Each array of disposable bone plate sizers has a plurality of sizers having differing configurations and sizes, each of the disposable sizers in a given array corresponding to a particular bone screw size. Each of the disposable bone plate sizers in a given array are mounted upon and easily detachable from a frame member. The disposable bone plate sizers may be malleable such that may be manipulated by the surgeon into the desired three-dimensional shape to match the contour of the bone segments to be joined, thereby providing a template to shape the corresponding permanent bone plate.

    Abstract translation: 一个或多个具有相应永久骨板阵列的柔性一次性骨板分粒器阵列，使用这些骨板大小分析器和/或模板的系统以及使用这些骨板大小分析器和/或模板的方法 体现。 一次性骨板分级器的每个阵列具有多个具有不同配置和尺寸的分级器，给定阵列中的每个一次性分级器对应于特定的骨螺钉尺寸。 给定阵列中的每个一次性骨板筛分器安装在框架构件上并且可以容易地从框架构件上拆卸下来。 一次性骨板尺寸测定器可以是可延展的，从而可由外科医生操纵成期望的三维形状以匹配待接合的骨段的轮廓，由此提供用于成形相应的永久骨板的模板。

    PREPARATION AND APPLICATIONS OF 3D BIOPRINTING BIOINKS FOR REPAIR OF BONE DEFECTS, BASED ON CELLULOSE NANOFIBRILS HYDROGELS WITH NATURAL OR SYNTHETIC CALCIUM PHOSPHATE PARTICLES
    4.
    发明申请
    PREPARATION AND APPLICATIONS OF 3D BIOPRINTING BIOINKS FOR REPAIR OF BONE DEFECTS, BASED ON CELLULOSE NANOFIBRILS HYDROGELS WITH NATURAL OR SYNTHETIC CALCIUM PHOSPHATE PARTICLES 审中-公开
    基于天然或合成磷酸钙颗粒的纤维素纳米纤维水凝胶修复骨缺损的三维生物活性生物活性剂的制备及应用

    公开(公告)号：WO2018078130A1

    公开(公告)日：2018-05-03

    申请号：PCT/EP2017/077669

    申请日：2017-10-27

    Applicant: GATENHOLM, Paul ,  MARTINEZ, Hector ,  SCHETNNO, Michela ,  GATENHOLM, Erik

    Inventor： GATENHOLM, Paul ,  MARTINEZ, Hector ,  SCHETNNO, Michela ,  GATENHOLM, Erik

    IPC: A61L27/38 ,  A61L27/46 ,  A61L27/52 ,  B33Y70/00 ,  B29C64/106 ,  B29C64/165

    CPC classification number: A61L27/46 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3865 ,  A61L27/52 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/12 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08L1/00

    Abstract: The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40 %w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process. Calcium containing particles can be isolated from autologous bone, allogenic bone or xenogeneic bone but can be also isolated from minerals or be prepared by synthesis. Preferable Calcium containing particles consist of β- tricalcium phosphate which is resorbable or natural bone powder, preferably of human or porcine origin. The particles described in the present invention have particle size smaller than 400 microns, or more preferably smaller than 200 microns, to make it possible to handle in printing nozzle without clogging and to obtain a good resolution. Cellulose nanofibrils can be produced by bacteria orbe isolated from plants. They can be neutral, charged or oxidized to be biodegradable. The bioink can be additionally supplemented by other biopolymers which provide crosslinking. Such biopolymers can be alginates, chitosans, modified hyaluronic acid or modified collagen derived biopolymers.

    Abstract translation: 本发明涉及由天然或合成的含钙颗粒组成的由纤维素纳米纤维水凝胶组成的生物链的制备。 含钙颗粒的浓度可以在1％至40％w / v之间。 这种生物链可以是3D生物打印的，有或没有人类或动物细胞。 同轴针可用于填充有钙颗粒的纤维素纳米纤维水凝胶可用作壳和另一种与细胞混合的基于水凝胶的生物链可用作芯或相反。 由于纤维素纳米原纤维的剪切变稀特性，这种3D生物打印的构造物显示出高孔隙率，这提供了优异的印刷保真度。 它们还具有优异的机械性能，并且易于作为需要修复的患者专用骨腔的大型结构来处理。 孔隙促进血管生成，这对氧气和营养供应至关重要。 孔隙还使得可以进一步募集促进骨愈合过程的细胞。 含钙颗粒可以从自体骨，同种异体骨或异种骨分离，但也可以从矿物中分离或通过合成制备。 优选的含钙颗粒由可吸收的或天然骨粉的β-磷酸三钙，优选人或猪来源组成。 在本发明中描述的颗粒具有小于400微米，或者更优选小于200微米的粒度，使得可以在印刷喷嘴中处理而不堵塞并获得良好的分辨率。 纤维素纳米纤丝可以由细菌产生或从植物分离。 它们可以是中性的，带电的或氧化的可生物降解的。 生物链可以另外由提供交联的其他生物聚合物补充。 这种生物聚合物可以是藻酸盐，壳聚糖，修饰的透明质酸或改性的胶原衍生的生物聚合物。

    POWDER AND PROCESS
    8.
    发明申请
    POWDER AND PROCESS 审中-公开
    粉末和过程

    公开(公告)号：WO2018025020A1

    公开(公告)日：2018-02-08

    申请号：PCT/GB2017/052225

    申请日：2017-07-31

    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY

    Inventor： CURRIE, Edwin Peter Kennedy ,  HOPPE, Alexander ,  EDGAR, Jonathan Andrew

    IPC: A61L27/44 ,  C03C4/00

    CPC classification number: C03C11/007 ,  A61L27/12 ,  A61L27/446 ,  A61L27/46 ,  A61L2430/02 ,  C03C3/097 ,  C03C4/0007

    Abstract: The present invention relates to a powder suitable for use in additive layer manufacturing (ALM). The powder comprises bioactive glass particles and particles of a polymeric binder material having a glass transition temperature (T g ) of at least 30°C. The present invention further relates to a process for making a glass article using the powder, a method of preparing such a powder, a glass article and the use of the powder in the additive layer manufacture of a glass article.

    Abstract translation: 本发明涉及适用于添加剂层制造（ALM）的粉末。 该粉末包含生物活性玻璃颗粒和玻璃化转变温度（Tg）至少为30℃的聚合物粘合剂材料颗粒。 本发明进一步涉及使用该粉末制造玻璃制品的方法，制备这种粉末的方法，玻璃制品以及该粉末在玻璃制品的添加剂层制造中的用途。

    AMORPHOUS STRONTIUM POLYPHOSPHATE MICROPARTICLES FOR TREATMENT OF OSTEOPOROSIS AND INDUCING BONE CELL MINERALIZATION
    9.
    发明申请
    AMORPHOUS STRONTIUM POLYPHOSPHATE MICROPARTICLES FOR TREATMENT OF OSTEOPOROSIS AND INDUCING BONE CELL MINERALIZATION 审中-公开
    非晶态锶多磷酸盐微粒治疗骨质疏松症及诱导骨细胞矿化

    公开(公告)号：WO2018019605A1

    公开(公告)日：2018-02-01

    申请号：PCT/EP2017/067736

    申请日：2017-07-13

    Applicant: NANOTECMARIN GMBH

    Inventor： MUELLER, Werner Ernst Ludwig Georg

    IPC: A61L27/02 ,  A61L27/14 ,  A61K9/16

    CPC classification number: A61L27/025 ,  A61K9/16 ,  A61L27/14 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2300/622 ,  A61L2300/624 ,  A61L2430/02

    Abstract: This invention concerns a novel preparation of amorphous strontium-polyphosphate microparticles ("Sr-a-poly P-MP") that can be used for treatment of osteoporosis after oral administration and as a regeneratively active implant material for bone repair. The inventive particles are morphogenetically active. They induce a multifold higher expression of alkaline phosphatase and bone morphogenetic protein 2 than amorphous calcium-polyphosphate microparticles ("Ca-a-polyP-MP"), but, unexpectedly, the expression of sclerostin, an inhibitor of bone cell differentiation and mineralization is, if at all, only slightly affected, in contrast to "Ca-a-poly P-MP" that strongly increases the expression of this protein. As a result, the inventive particles show a significantly higher stimulatory effect on the growth of human mesenchymal stem cells (MSC) and on mineralization of osteoblast-like SaOS-2 cells compared to "Ca-a-polyP-MP" and the strontium salt. The superior properties of "Sr-a-poly P- MP" compared to "Ca-a-polyP-MP" were confirmed in animal studies which revealed an increased healing/mineralization of bone defects even after short implantation periods. Consequently, the inventive microparticles ("Sr-a-polyP-MP") are potentially applicable both in therapy of osteoporotic patients and bone repair.

    Abstract translation: 本发明涉及可用于口服给药后治疗骨质疏松症和作为再生有效植入物的无定形多聚磷酸锶微粒（“Sr-α-poly P-MP”）的新制剂 骨修复材料。 本发明的颗粒具有形态发生活性。 它们比无定形多磷酸钙微粒（“Ca-a-polyP-MP”）诱导碱性磷酸酶和骨形态发生蛋白2的多倍高表达，但出乎意料地表达了骨硬化蛋白，骨细胞分化和矿化的抑制剂 与“Ca-α-poly P-MP”相比，如果有的话，只受到轻微影响。 强烈增加这种蛋白质的表达。 结果，与“Ca-a-polyP-MP”相比，本发明的颗粒对人类间充质干细胞（MSC）的生长和成骨细胞样SaOS-2细胞的矿化显示出显着更高的刺激作用。 和锶盐。 “Sr-a-poly P-MP” 与“Ca-α-polyP-MP”相比， 在动物研究中证实，即使在短的着床期后也显示骨缺损愈合/矿化增加。 因此，本发明的微粒（“Sr-a-polyP-MP”）可能适用于骨质疏松症患者的治疗和骨修复。

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