公开(公告)号：WO2021123378A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/087317

申请日：2020-12-18

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  REICHARDT, Nicole ,  SAVIGNAC, Helene ,  CHETAL, Sasha ,  DINAN, Ted ,  CRYAN, John

IPC: A61K35/74 ,  A61K9/00 ,  A61K9/19 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61K9/0053

Abstract: The invention provides compositions comprising bacterial strains and the use of such compositions in the treatment of disease, including in central nervous system disorders.

公开(公告)号：WO2020120714A1

公开(公告)日：2020-06-18

申请号：PCT/EP2019/084991

申请日：2019-12-12

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  ETTORRE, Anna ,  AHMED, Suaad ,  CRYAN, John ,  DINAN, Ted

IPC: A61K35/741 ,  A61K45/06 ,  A61P25/24

Abstract: The invention provides a composition comprising a bacterial strain of the genus Megasphaera, for use in the treatment or prevention of a disorder characterised by serotonin deficiency.

公开(公告)号：WO2022003057A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/068072

申请日：2021-06-30

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： DINAN, Ted ,  CRYAN, John ,  REID, Sarah ,  AHMED, Suaad ,  ETTORRE, Anna

IPC: A61K35/74 ,  A61P25/28

Abstract: The invention provides compositions comprising one or more bacterial strains for treating or preventing a central nervous system disease or disorder.

公开(公告)号：WO2021004958A3

公开(公告)日：2021-01-14

申请号：PCT/EP2020/068867

申请日：2020-07-03

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  REICHARDT, Nicole ,  SAVIGNAC, Helene ,  CHETAL, Sasha ,  DINAN, Ted ,  CRYAN, John ,  YUILLE, Samantha

IPC: A61K35/74 ,  A23L33/135 ,  A61K9/19 ,  C12R1/01 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61K35/742 ,  C12N1/20

Abstract: The invention provides pharmaceutical compositions comprising bacteria and the use of such compositions in the treatment of disease.

公开(公告)号：WO2021004958A2

公开(公告)日：2021-01-14

申请号：PCT/EP2020/068867

申请日：2020-07-03

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  REICHARDT, Nicole ,  SAVIGNAC, Helene ,  CHETAL, Sasha ,  DINAN, Ted ,  CRYAN, John ,  YUILLE, Samantha

IPC: A61K35/74

Abstract: The invention provides pharmaceutical compositions comprising bacteria and the use of such compositions in the treatment of disease.

公开(公告)号：WO2021098991A1

公开(公告)日：2021-05-27

申请号：PCT/EP2020/063854

申请日：2020-05-18

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  REICHARDT, Nicole ,  SAVIGNAC, Helene ,  CHETAL, Sasha ,  DINAN, Ted ,  CRYAN, John

IPC: A61K35/74 ,  A61P25/28 ,  A61P3/00

Abstract: The invention provides compositions comprising a bacterial strain of the genus Fusicatenibacter and their use in medicine.

公开(公告)号：WO2020120714A8

公开(公告)日：2020-06-18

申请号：PCT/EP2019/084991

申请日：2019-12-12

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  ETTORRE, Anna ,  AHMED, Suaad ,  CRYAN, John ,  DINAN, Ted

IPC: A61K35/741 ,  A61K45/06 ,  A61P25/24

Abstract: The invention provides a composition comprising a bacterial strain of the genus Megasphaera, for use in the treatment or prevention of a disorder characterised by serotonin deficiency.

公开(公告)号：WO2018215759A1

公开(公告)日：2018-11-29

申请号：PCT/GB2018/051390

申请日：2018-05-22

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： SAVIGNAC, Helene Myriam ,  MULDER, Imke Elisabeth ,  DINAN, Ted ,  CRYAN, John

IPC: A61K35/74 ,  A61P25/00 ,  C12N1/20

Abstract: The invention provides compositions comprising bacterial strains for treating and preventing central nervous system disorders and conditions.

公开(公告)号：WO2021099624A1

公开(公告)日：2021-05-27

申请号：PCT/EP2020/082991

申请日：2020-11-20

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  REICHARDT, Nicole ,  SAVIGNAC, Helene ,  CHETAL, Sasha ,  DINAN, Ted ,  CRYAN, John

IPC: A61K35/74 ,  A61P25/28

Abstract: The invention provides compositions comprising a bacterial strain of the genus Fusicatenibacter and their use in medicine.

公开(公告)号：WO2019215346A1

公开(公告)日：2019-11-14

申请号：PCT/EP2019/062238

申请日：2019-05-13

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  FOTIADOU, Parthena ,  HOLT, Amy Beth ,  AHMED, Suaad ,  ETTORRE, Anna ,  YUILLE, Samantha ,  DINAN, Ted ,  CRYAN, John

IPC: A61K35/74 ,  A61K39/02 ,  A23L33/135 ,  A61P1/00 ,  A61P11/06 ,  A61P3/10 ,  A61P17/06 ,  A61P19/02 ,  A61P37/00 ,  A61P35/00 ,  A61P43/00

Abstract: The invention provides a composition comprising a bacterial strain of the genus Megasphaera , for use in stimulating the immune system in subject.