公开(公告)号：WO2015105981A3

公开(公告)日：2015-10-22

申请号：PCT/US2015010631

申请日：2015-01-08

Applicant: ABBOTT LAB

Inventor： EDENS NEILE ,  GELLING RICHARD ,  SATHYAVAGEESWARAN SHREERAM

IPC: A23L1/29 ,  A23L1/305 ,  A61K31/19

CPC classification number: A61K45/06 ,  A23L33/10 ,  A23L33/17 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/155 ,  A61K31/19 ,  A61K31/573 ,  A61K2300/00 ,  A23V2200/316

Abstract: A method of increasing or maintaining lean body mass in leucine conversion-compromised subjects and subjects undergoing treatment for diabetes is provided. The method includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to a subject with compromised leucine conversion efficiency or a subject undergoing treatment for insulin resistance associated with diabetes. Administration of HMB to a leucine conversion-compromised subject or a subject undergoing treatment for diabetes is effective to increase or maintain the human's lean body mass.

Abstract translation: 提供了在亮氨酸转化受损的受试者和经历糖尿病治疗的受试者中增加或维持瘦体重的方法。 所述方法包括向受试者施用有效量的β-羟基-β-甲基丁酸酯（HMB），所述对象具有降低的亮氨酸转化效率或经历与糖尿病相关的胰岛素抵抗治疗的受试者。 将HMB给予亮氨酸转化受损对象或正在接受糖尿病治疗的受试者有效地增加或维持人的瘦体重。

公开(公告)号：WO2008030998A3

公开(公告)日：2008-05-29

申请号：PCT/US2007077824

申请日：2007-09-07

Applicant: ABBOTT LAB ,  ATKINSON JUDITH R ,  EDENS NEILE ,  DEWILLE NORMANELLA T ,  MAZER TERRY ,  YOSICK KELLEY J ,  OGILVIE ALLISON ,  WEARLY DOUGLAS

Inventor： ATKINSON JUDITH R ,  EDENS NEILE ,  DEWILLE NORMANELLA T ,  MAZER TERRY ,  YOSICK KELLEY J ,  OGILVIE ALLISON ,  WEARLY DOUGLAS

IPC: A23L1/29 ,  A23L1/00 ,  A23L1/164

CPC classification number: A23L7/126 ,  A23L7/122 ,  A23P20/12 ,  A23P20/18 ,  A23P20/20 ,  A23V2002/00 ,  A23V2200/22 ,  A23V2200/328 ,  A23V2250/606

Abstract: The present invention provides a food product comprising: a formed reduced glycemic response cereal component; and a non-sticky reduced glyccmic response sweetener coating over the formed cereal component, the sweetener coating comprising: a first sticky layer comprising at least about 30% fructose (of the total sweetener coating); a second less sticky layer having a DE value of about 60 or less and comprising up to about 17% fructose and at least about 1% non-fructose carbohydrates (of the total sweetener coating); and third layer comprising crystalline fructose. The present invention also provides a process for forming the sweetener coating over the formed cereal component comprising the following steps: (a) providing a formed cereal component having thereon a first sticky layer comprising fructose; (b) forming over the first sticky layer a less sticky second layer comprising non- fructose carbohydrates and optionally fructose; and (c) applying crystalline fructose over the second layer.

Abstract translation: 本发明提供了一种食品，其包含：形成的减少血糖反应谷物组分; 和在形成的谷物组分上的非粘性降低的糖基应答甜味剂包衣，所述甜味剂包衣包含：第一粘性层，其包含至少约30％的果糖（总甜味剂包衣）; DE值为约60或更低且包含（总甜味剂包衣的）至多约17％果糖和至少约1％非果糖碳水化合物的第二较少粘性层; 和包含结晶果糖的第三层。 本发明还提供了一种在形成的谷物组分上形成甜味剂包衣的方法，包括以下步骤：（a）提供其上具有包含果糖的第一粘性层的成形谷物组分; （b）在第一粘性层上形成包含非果糖碳水化合物和任选的果糖的较少粘性的第二层; 和（c）在第二层上施用结晶果糖。

公开(公告)号：WO2006102451A2

公开(公告)日：2006-09-28

申请号：PCT/US2006010468

申请日：2006-03-21

Applicant: ABBOTT LAB ,  MAZER TERRY ,  EDENS NEILE ,  BERGANA MARTI ,  SHEARER KATI ,  WOLF DAVID ,  WALTON JOSEPH

Inventor： MAZER TERRY ,  EDENS NEILE ,  BERGANA MARTI ,  SHEARER KATI ,  WOLF DAVID ,  WALTON JOSEPH

CPC classification number: A61K31/223 ,  A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K2300/00 ,  Y10S514/866

Abstract: Disclosed are compositions, including low-calorie beverages or liquids, comprising isoleucine, leucine, valine, cysteine, and methionine, in specified amounts, weight ratios, or both. The compositions are especially useful in treating individuals afflicted with impaired glucose tolerance or diabetes.

Abstract translation: 公开了包含特定量，重量比或两者的异亮氨酸，亮氨酸，缬氨酸，半胱氨酸和甲硫氨酸的组合物，包括低热量饮料或液体。 该组合物特别可用于治疗患有葡萄糖耐量降低或糖尿病的个体。

公开(公告)号：WO2014152606A3

公开(公告)日：2015-02-05

申请号：PCT/US2014027524

申请日：2014-03-14

Applicant: ABBOTT LAB

Inventor： LUO MENGHUA ,  PEREIRA SUZETTE ,  EDENS NEILE ,  DAVIS GERARD ,  GAWEL SUSAN ,  CHANDRAN RAJ

IPC: A61K31/19 ,  A61P3/10

CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor- Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.

Abstract translation: 提供了使用生物标志物的胰岛素抵抗生物标志物和相关方法。 生物标志物可以是血液生物标志物，包括C肽，胰岛素样生长因子结合蛋白2（IGFBP-2）和瘦蛋白。 还提供了一种减少长期身体不活动对经历长时间身体不活动的受试者或预期在不久的将来会经历长时间身体不活动的受试者的胰岛素抵抗的影响的方法。