公开(公告)号：WO2017093819A1

公开(公告)日：2017-06-08

申请号：PCT/IB2016/055927

申请日：2016-10-04

申请人： ABDOLAHAD, Mohammad

发明人： ABDOLAHAD, Mohammad ,  SAEIDI, Ali ,  GHAROONI, Milad

IPC分类号： G01N27/02 ,  C23C28/00

CPC分类号： G01N27/3278 ,  C23C14/16 ,  C23C28/321 ,  C23C28/322 ,  C23C28/34 ,  C25F3/08 ,  G01N27/028 ,  G01N27/283 ,  G01N33/4833

摘要： An electrical probe (100) configured to measure an e1ectrical response from a biological cell (501) includes a microwire (101) having a sharpened tip (102), a catalyst layer formed on the sharpened tip (102) of the microwire (101), and an array of nanotube electrodes (103) vertically aligned on the catalyst layer.

摘要翻译： 被配置为测量来自生物细胞（501）的电学响应的电探针（100）包括具有尖锐尖端（102）的微丝（101），形成在尖锐尖端上的催化剂层（ 102）以及在催化剂层上垂直排列的纳米管电极阵列（103）。

公开(公告)号：WO2022053861A1

公开(公告)日：2022-03-17

申请号：PCT/IB2020/061868

申请日：2020-12-13

申请人： ABDOLAHAD, Mohammad ,  SAEIDI, Ali

发明人： ABDOLAHAD, Mohammad ,  SAEIDI, Ali

IPC分类号： A61N1/18 ,  G01N27/327 ,  G01N27/02 ,  G01N27/28

摘要： Disclosed herein is an electromechanical system for detecting cancerous state of a single cell. The system includes an aspirating mechanism, an electrical measurement mechanism, and a processing mechanism. The aspirating mechanism is configured to extract a single cell from a suspension of cells, hold the extracted single cell, and apply a mechanical aspiration to the held single cell by applying a suction force the cell. The electrical measurement mechanism is configured to apply a set of electrical signals to the single cell before and after applying the mechanical aspiration, measure a first and a second set of electrical responses from the held single cell corresponding to the applied set of electrical signals before and after the mechanical aspiration. The processing mechanism is configured to detect cancerous state of the single cell based on a difference between the first set and the second set of electrical responses.

公开(公告)号：WO2017093820A1

公开(公告)日：2017-06-08

申请号：PCT/IB2016/055929

申请日：2016-10-04

申请人： ABDOLAHAD, Mohammad

发明人： ABDOLAHAD, Mohammad ,  SAEIDI, Ali ,  GHAROONI, Milad

IPC分类号： G01N33/483 ,  G01N27/02

CPC分类号： G01N27/3278 ,  C23C14/16 ,  C23C28/321 ,  C23C28/322 ,  C23C28/34 ,  C25F3/08 ,  G01N27/028 ,  G01N27/283 ,  G01N33/4833

摘要： Single-cell-based electromechanical method (400) for cancerous state detection including the steps of preparing a suspension of individually suspended biological cells (step 401), extracting a single cell (501, 804) from the suspension (step 402), holding the extracted single cell (501, 804) from the suspension (step 403), measuring a first electrical response of the held single cell (501, 804) (step 404), step-wised mechanical aspirating the held single cell (501, 804) to form a mechanically deformed cell (step 405), and measuring an electrical response of the held single cell (501, 804) after each step of mechanical aspirating (step 406). The cancerous state of the single cell (501, 804) is determined based on the changes in the measured electrical responses.

摘要翻译： 用于癌症状态检测的基于单细胞的机电方法（400）包括以下步骤：制备单独悬浮的生物细胞的悬浮液（步骤401）;从所述单细胞系统中提取单个细胞（501,804） （步骤402），将提取的单细胞（501,804）从悬浮液中保持（步骤403），测量所保持的单细胞（501,804）的第一电响应（步骤404），逐步机械吸气 （501,804）以形成机械变形的电池（步骤405），并且在每个机械抽吸步骤（步骤406）之后测量所保持的单电池（501,804）的电响应。 基于所测量的电响应的变化来确定单个细胞（501,804）的癌症状态。