公开(公告)号：WO2015003002A1

公开(公告)日：2015-01-08

申请号：PCT/US2014/045145

申请日：2014-07-01

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： JONES, Todd, K. ,  CISAR, Justin, S. ,  GRICE, Cheryl, A. ,  WANG, Dong-Hui ,  WEBER, Olivia, D.

IPC: A61K31/407

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, Ν,Ν-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.

Abstract translation: 本发明提供了吡咯并吡咯氨基甲酸酯和相关的有机化合物，含有这些化合物的组合物，医疗试剂盒和使用这些化合物和组合物治疗医学病症的方法，例如实体瘤，肥胖症，唐氏综合症，阿尔茨海默病或疼痛， 在病人身上 八氢吡咯并吡咯烷基氨基甲酸酯可以衍生自六氟异丙醇，N，N'-二琥珀酰亚胺等。 还描述了在MAGL，FAAH和ABHD6测定中氨基甲酸酯的活性。