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公开(公告)号：WO2018007442A1
公开(公告)日：2018-01-11
申请号：PCT/EP2017/066769
申请日：2017-07-05
申请人： ABLYNX N.V.
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/18 , C07K2317/22 , C07K2317/31
摘要： Methods are provided for the treatment of IL-6R related diseases. More specifically, specific dose regimens and pre-filled syringes are provided for subcutaneous administration, to subjects suffering an IL-6R related disease, of immunoglobulin single variable domains that bind IL-6R.
摘要翻译： 提供了治疗IL-6R相关疾病的方法。 更具体地说，提供了具体的剂量方案和预填充注射器，用于皮下给予患有IL-6R相关疾病的结合IL-6R的免疫球蛋白单可变结构域的受试者。
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2.发明申请IL-6R SINGLE VARIABLE DOMAIN ANTIBODIES FOR TREATMENT OF IL-6R RELATED DISEASES 审中-公开IL-6R单变量抗体治疗IL-6R相关疾病
公开(公告)号：WO2018029182A1
公开(公告)日：2018-02-15
申请号：PCT/EP2017/070045
申请日：2017-08-08
申请人： ABLYNX N.V.
IPC分类号： C07K16/18 , C07K16/28 , A61K39/395 , A61K31/519
CPC分类号： C07K16/2866 , A61K31/519 , A61K39/395 , C07K16/18 , C07K2317/31 , C07K2317/569 , C07K2317/90 , A61K2300/00
摘要： Methods are provided for the treatment of IL-6R related diseases involving a combination therapy. More specifically, specific dose regimens and pre-filled syringes are provided for subcutaneous administration, to subjects suffering an IL-6R related disease, of immunoglobulin single variable domains that bind IL-6R, in combination with at least one additional therapeutic agent, such as methotrexate.
摘要翻译： 为涉及联合治疗的IL-6R相关疾病的治疗提供了方法。 更具体地说，提供了特定剂量方案和预填充注射器，用于皮下施用，患有IL-6R相关疾病的受试者，结合IL-6R的免疫球蛋白单可变结构域，与至少一种另外的治疗剂例如 氨甲蝶呤。
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