公开(公告)号：WO2014100815A3

公开(公告)日：2014-08-21

申请号：PCT/US2013077501

申请日：2013-12-23

Applicant: ABT HOLDING CO

Inventor： ROBARGE MIKE ,  HARRINGTON JOHN ,  GERRISH DAVID ,  MECOM JOHN

IPC: A61K31/55

CPC classification number: C07D223/32 ,  C07D401/04 ,  C07D417/04 ,  C07D491/048 ,  C07D491/052

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Abstract translation: 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是苯并氮杂化合物。 这些化合物是5-羟色胺受体（5-HT2c）配体，可用于治疗其中需要调节血清素受体（5-HT2c）活性（例如成瘾，焦虑，抑郁，肥胖等）的疾病，病症和病症， 。