公开(公告)号：WO2014177978A3

公开(公告)日：2015-02-19

申请号：PCT/IB2014060966

申请日：2014-04-24

申请人： ALEMBIC PHARMACEUTICALS LTD ,  JAYARAMAN VENKAT RAMAN

发明人： JAYARAMAN VENKAT RAMAN ,  PATEL SAMIR ,  DHOL SNEHAL ,  RAY VISHAL

IPC分类号： C07C253/30 ,  C07C253/14 ,  C07C255/23

CPC分类号： C07C253/30 ,  C07C253/34 ,  C07C255/19 ,  C07C255/23

摘要： The present invention provides an improved process for preparation of Teriflunomide of formula (I).

摘要翻译： 本发明提供了制备式（I）特立氟胺的改进方法。

公开(公告)号：WO2011004282A4

公开(公告)日：2011-10-27

申请号：PCT/IB2010052821

申请日：2010-06-22

申请人： ALEMBIC PHARMACEUTICALS LTD ,  PONNAIAH RAVI ,  PATEL SAMIR ,  DHOL SNEHAL ,  RAY VISHAL

发明人： PONNAIAH RAVI ,  PATEL SAMIR ,  DHOL SNEHAL ,  RAY VISHAL

IPC分类号： C07C255/21 ,  A61K31/44 ,  A61P37/06

CPC分类号： C07C255/23 ,  Y10T428/2982

摘要： The present invention provides a new polymorph Form I of Teriflunomide sodium and a process for preparation thereof. The present invention provides an amorphous form of Teriflunomide sodium and a process for preparation thereof. The present invention provides a new polymorph Form I of Teriflunomide potassium and a process for preparation thereof. The present invention provides an amorphous form of Teriflunomide potassium and a process for preparation thereof. The present invention also provides particle size of Teriflunomide and its salts.