公开(公告)号：WO2019073062A1

公开(公告)日：2019-04-18

申请号：PCT/EP2018/077953

申请日：2018-10-12

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： RALLABANDI, Bala Ramesha Chary ,  PRATHAP, Vamshi Ramana ,  GOLLAPUDI, Krishna Mohan ,  VELUSAMY, Bala Subramanian ,  BANDLA, Srimannarayana ,  SCHLEHAHN, Hendrik ,  RUCHATZ, Dieter

IPC: A61K9/20 ,  A61K31/225 ,  A61K31/41

CPC classification number: A61K9/2009 ,  A61K9/2095 ,  A61K31/216 ,  A61K31/41 ,  A61K2300/00

Abstract: The present invention relates to a tablet for oral administration containing valsartan and sacubitril, preferably as sodium salts or as a complex of valsartan disodium and sacubitril monosodium, preferably LCZ696. The tablet is prepared by dry-granulation or direct compression and contains a mesoporous inorganic stabilizer, e.g. mesoporous silica (Syloid®).