公开(公告)号：WO2019073062A1

公开(公告)日：2019-04-18

申请号：PCT/EP2018/077953

申请日：2018-10-12

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： RALLABANDI, Bala Ramesha Chary ,  PRATHAP, Vamshi Ramana ,  GOLLAPUDI, Krishna Mohan ,  VELUSAMY, Bala Subramanian ,  BANDLA, Srimannarayana ,  SCHLEHAHN, Hendrik ,  RUCHATZ, Dieter

IPC: A61K9/20 ,  A61K31/225 ,  A61K31/41

CPC classification number: A61K9/2009 ,  A61K9/2095 ,  A61K31/216 ,  A61K31/41 ,  A61K2300/00

Abstract: The present invention relates to a tablet for oral administration containing valsartan and sacubitril, preferably as sodium salts or as a complex of valsartan disodium and sacubitril monosodium, preferably LCZ696. The tablet is prepared by dry-granulation or direct compression and contains a mesoporous inorganic stabilizer, e.g. mesoporous silica (Syloid®).

公开(公告)号：WO2022034232A1

公开(公告)日：2022-02-17

申请号：PCT/EP2021/072649

申请日：2021-08-13

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： PRATHAP, Vamshi Ramana ,  KALAMATA, Venkatasimhadri Naidu ,  MUPKALKER, Ashwini Kumar ,  VELCHURI, Srikanth ,  RALLABANDI, Bala Ramesha Chary ,  MADALLAPALLI, Kiran Kumar ,  SCHLEHAHN, Hendrik ,  FITZNER, Ansgar

IPC: A61K9/14 ,  A61K9/20 ,  A61K31/496

Abstract: The present invention relates to a gastro-resistant high-strength unit dosage form comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains 300 mg posaconazole and an enteric polymer in a specific weight ratio. The unit dosage form may be a capsule or optionally film-coated tablet.

公开(公告)号：WO2019086725A3

公开(公告)日：2019-05-09

申请号：PCT/EP2019/055706

申请日：2019-03-07

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： STAVER, Ruslan ,  PRATHAP, Vamshi Ramana ,  VADLA, Hari Kiran Chary ,  RALLABANDI, Bala Ramesha Chary ,  SCHLEHAHN, Hendrik

IPC: A61K9/20 ,  A61K31/4152 ,  A61P7/02

Abstract: The present invention relates to a pharmaceutical tablet composition comprising eltrombopag olamine, one or more reducing sugars, and one or more polymeric binder agents, a production process therefore, a pharmaceutical tablet composition comprising eltrombopag olamine, one or more reducing sugars, and one or more polymeric binder agents obtainable by the production process, a use / method of use of the pharmaceutical tablet compositions in the treatment or prophylaxis of immune (idiopathic) thrombocytopenic purpura (ITP), thrombocytopenia and/or acquired severe a plastic anaemia (SAA).

公开(公告)号：WO2019086725A2

公开(公告)日：2019-05-09

申请号：PCT/EP2019/055706

申请日：2019-03-07

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： STAVER, Ruslan ,  PRATHAP, Vamshi Ramana ,  VADLA, Hari Kiran Chary ,  RALLABANDI, Bala Ramesha Chary ,  SCHLEHAHN, Hendrik

Abstract: The present invention relates to a pharmaceutical tablet composition comprising eltrombopag olamine, one or more reducing sugars, and one or more polymeric binder agents, a production process therefore, a pharmaceutical tablet composition comprising eltrombopag olamine, one or more reducing sugars, and one or more polymeric binder agents obtainable by the production process, a use / method of use of the pharmaceutical tablet compositions in the treatment or prophylaxis of immune (idiopathic) thrombocytopenic purpura (ITP), thrombocytopenia and/or acquired severe a plastic anaemia (SAA).

公开(公告)号：WO2018178295A1

公开(公告)日：2018-10-04

申请号：PCT/EP2018/058207

申请日：2018-03-29

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： RALLABANDI, Bala Ramesha Chary ,  PRATHAP, Vamshi Ramana ,  GOLLAPUDI, Rajesh Krishna Mohan ,  SCHLEHAHN, Hendrik ,  RUCHATZ, Dieter

IPC: A61K9/14 ,  A61K9/20

CPC classification number: A61K9/146 ,  A61K9/2027 ,  A61K9/2077

Abstract: The present invention relates to a solid unit dosage form for oral administration (tablet or granules) containing a solid dispersion of valsartan and sacubitril in a polymeric matrix. The solid dispersion is prepared by hot-melt extrusion and may contain the active ingredients preferably in a non-crystalline state. LCZ696, (pseudo)polymorphic forms thereof as well as the individual drugs, e.g. valsartan disodium and sacubitril monosodium, may be subjected to the hot-melt extrusion process.

公开(公告)号：WO2018197088A1

公开(公告)日：2018-11-01

申请号：PCT/EP2018/055618

申请日：2018-03-07

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： STAVER, Ruslan ,  PRATHAP, Vamshi Ramana ,  VADLA, Hari Kiran Chary ,  RALLABANDI, Bala Ramesha Chary ,  SCHLEHAHN, Hendrik

IPC: A61K9/20 ,  A61K31/4152

Abstract: The present invention relates to a pharmaceutical tablet composition comprisingeltrombopag olamine and one or more reducing sugars, a production process therefore, a pharmaceutical tablet composition comprising eltrombopag olamine and one or more reducing sugars obtainable by the production process, a use / method of use of the pharmaceutical tablet compositions in the treatment or prophylaxis of immune (idiopathic) thrombocytopenic purpura (ITP),thrombocytopenia and/or acquired severe aplastic anaemia(SAA).

公开(公告)号：WO2017025292A1

公开(公告)日：2017-02-16

申请号：PCT/EP2016/067469

申请日：2016-07-21

Applicant: ALFRED E. TIEFENBACHER (GMBH & CO. KG)

Inventor： PRATHAP, Vamshi Ramana ,  KALAMATA, Venkatasimhadri Naidu ,  RALLABANDI, Bala Ramesha Chary ,  KATAKAM, Vinay Kumar ,  SCHLEHAHN, Hendrik

IPC: A61K9/16 ,  A61K31/00

CPC classification number: A61K9/1635 ,  A61K9/1641 ,  A61K31/00

Abstract: The present invention relates to a gastro-resistant pharmaceutical composition comprising a solid solution prepared by hot-melt extrusion, whereby the solid solution contains posaconazole, an enteric polymer and a non-enteric polymer. The composition is preferably a granulate material that can be filled into a capsule or compressed into a tablet.

Abstract translation: 本发明涉及包含通过热熔挤出制备的固溶体的胃肠药物组合物，其中固溶体含有泊沙康唑，肠溶聚合物和非肠溶性聚合物。 组合物优选是可以填充到胶囊中或压制成片剂的颗粒材料。