公开(公告)号：WO2018204907A1

公开(公告)日：2018-11-08

申请号：PCT/US2018/031347

申请日：2018-05-07

Applicant: AMGEN INC.

Inventor： ABEL, Jeff ,  CUI, Lingwen ,  GOSWAMI, Devrishi ,  HUH, Joon ,  JAGANNATHAN, Bharadwaj ,  KANAPURAM, Sekhar ,  MCAULEY, Arnold ,  SCHNEIDER, Michael ,  SETHURAMAN, Ananthakrishnan, G. ,  TREUHEIT, Michael ,  ZHANG, Jun

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/00

Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.