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公开(公告)号：WO2018064307A3
公开(公告)日：2018-04-05
申请号：PCT/US2017/053967
申请日：2017-09-28
Applicant: AMGEN INC.
Inventor： HUH, Joon , STEVENSON, Riki , BONDARENKO, Pavel , NICHOLS, Andrew , REN, Da , AGRAWAL, Neeraj Jagdish , SMITH, Richard
Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
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Patent Agency Ranking
公开(公告)号：WO2018141910A1
公开(公告)日：2018-08-09
申请号：PCT/EP2018/052665
申请日：2018-02-02
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor： MCAULEY, Arnold , GHATTYVENKATAKRISHNA, Pavan , ABEL, Jeff , HUH, Joon , POMPE, Cornelius , KANAPURAM, Sekhar , TREUHEIT, Michael , JAGANNATHAN, Bharadwaj
IPC: A61K39/395 , C07K16/28
Abstract: The present disclosure provides a low pH pharmaceutical composition comprising (a) an antibody constructs comprising a first domain binding to a target cell surface antigen, a second domain binding to a second antigen and preferably a third domain, which is a specific Fc modality, (b) at least one buffer agent, (c) at least one saccharide, and (d) at least one surfactant; and wherein the pH of the pharmaceutical composition is in the range of 3.5 to 6.
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公开(公告)号：WO2018064307A4
公开(公告)日：2018-04-05
申请号：PCT/US2017/053967
申请日：2017-09-28
Applicant: AMGEN INC.
Inventor： HUH, Joon , STEVENSON, Riki , BONDARENKO, Pavel , NICHOLS, Andrew , REN, Da , AGRAWAL, Neeraj Jagdish , SMITH, Richard
Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
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公开(公告)号：WO2020072306A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/053462
申请日：2019-09-27
Applicant: AMGEN INC.
Inventor： JAGANNATHAN, Bharadwaj , HUH, Joon , TREUHEIT, Michael , SHAN, Daxian
Abstract: The invention disclosed herein relates to methods for reducing aggregation of bispecific antibodies, for example reducing aggregation of bispecific T cell engager (BiTE) antibody constructs, resulting from storage under frozen conditions by holding the antibodies at certain temperatures after thaw.
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5.发明申请
公开(公告)号：WO2018204907A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/031347
申请日：2018-05-07
Applicant: AMGEN INC.
Inventor： ABEL, Jeff , CUI, Lingwen , GOSWAMI, Devrishi , HUH, Joon , JAGANNATHAN, Bharadwaj , KANAPURAM, Sekhar , MCAULEY, Arnold , SCHNEIDER, Michael , SETHURAMAN, Ananthakrishnan, G. , TREUHEIT, Michael , ZHANG, Jun
IPC: A61K39/395 , C07K16/28 , A61K47/00
Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.
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公开(公告)号：WO2018064307A2
公开(公告)日：2018-04-05
申请号：PCT/US2017/053967
申请日：2017-09-28
Applicant: AMGEN INC.
Inventor： HUH, Joon , STEVENSON, Riki , BONDARENKO, Pavel , NICHOLS, Andrew , REN, Da , AGRAWAL, Neeraj Jagdish , SMITH, Richard
Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
Abstract translation: 本发明涉及制备粘度降低的抗原结合蛋白的方法。 该方法通过用高粘度可变结构域亚家族中的残基替换与低粘度亚家族相关的残基来进行。 该方法进一步包括用具有低粘度的残基取代Fc结构域中的残基并将带电荷的残基添加到Fc结构域的C端。 本发明还涉及通过该方法产生的抗原结合蛋白。
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