公开(公告)号：WO2020050890A2

公开(公告)日：2020-03-12

申请号：PCT/US2019/036626

申请日：2019-06-11

Applicant: AMGEN INC.

Inventor： ALLEN, John Gordon ,  LANMAN, Brian Alan ,  CHEN, Jian ,  REED, Anthony B. ,  CEE, Victor J. ,  LIU, Longbin ,  LOPEZ, Patricia ,  WURZ, Ryan Paul ,  NGUYEN, Thomas T. ,  BOOKER, Shon ,  ALLEN, Jennifer Rebecca ,  CHU-MOYER, Margaret ,  AMEGADZIE, Albert ,  CHEN, Ning ,  GOODMAN, Clifford ,  LOW, Jonathan D. ,  MA, Vu Van ,  MINATTI, Ana Elena ,  NISHIMURA, Nobuko ,  PICKRELL, Alexander J. ,  WANG, Hui-Ling ,  SHIN, Youngsook ,  SIEGMUND, Aaron C. ,  YANG, Kevin C. ,  TAMAYO, Nuria A. ,  WALTON, Mary ,  XUE, Qiufen

Abstract: Provided herein are KRAS G12C inhibitors, such as [Insert Compound Here] composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：WO2021108404A1

公开(公告)日：2021-06-03

申请号：PCT/US2020/062011

申请日：2020-11-24

Applicant: AMGEN INC.

Inventor： ALLEN, Jennifer R. ,  AMEGADZIE, Albert ,  BOURBEAU, Matthew P. ,  CHEN, Ning ,  GOODMAN, Clifford ,  LATTANZI, Giulia ,  LINGARD, Iain ,  LIU, Qingyian ,  LOW, Jonathan D. ,  MA, Vu Van ,  MINATTI, Ana E. ,  POZZAN, Alfonso ,  REEVES, Corey ,  SIEGMUND, Aaron C. ,  TASSINI, Sabrina ,  TONELLI, Federica ,  WALTON, Mary

IPC: C07D471/04 ,  A61K31/517 ,  A61K31/519 ,  C07D487/04 ,  C07D498/04 ,  A61P3/00 ,  A61P9/00

Abstract: The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

公开(公告)号：WO2020050890A3

公开(公告)日：2020-03-12

申请号：PCT/US2019/036626

申请日：2019-06-11

Applicant: AMGEN INC.

Inventor： ALLEN, John Gordon ,  LANMAN, Brian Alan ,  CHEN, Jian ,  REED, Anthony B. ,  CEE, Victor J. ,  LIU, Longbin ,  LOPEZ, Patricia ,  WURZ, Ryan Paul ,  NGUYEN, Thomas T. ,  BOOKER, Shon ,  ALLEN, Jennifer Rebecca ,  CHU-MOYER, Margaret ,  AMEGADZIE, Albert ,  CHEN, Ning ,  GOODMAN, Clifford ,  LOW, Jonathan D. ,  MA, Vu Van ,  MINATTI, Ana Elena ,  NISHIMURA, Nobuko ,  PICKRELL, Alexander J. ,  WANG, Hui-Ling ,  SHIN, Youngsook ,  SIEGMUND, Aaron C. ,  YANG, Kevin C. ,  TAMAYO, Nuria A. ,  WALTON, Mary ,  XUE, Qiufen

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61P35/00 ,  A61K45/06

Abstract: Provided herein are KRAS G12C inhibitors, such as [Insert Compound Here] composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：WO2019213516A1

公开(公告)日：2019-11-07

申请号：PCT/US2019/030593

申请日：2019-05-03

Applicant: AMGEN INC.

Inventor： ALLEN, John Gordon ,  ALLEN, Jennifer Rebecca ,  MINATTI, Ana Elena ,  XUE, Qiufen ,  WURZ, Ryan Paul ,  TEGLEY, Christopher M. ,  PICKRELL, Alexander J. ,  NGUYEN, Thomas T. ,  MA, Vu Van ,  LOPEZ, Patricia ,  LIU, Longbin ,  KOPECKY, David John ,  FROHN, Michael J. ,  CHEN, Ning ,  CHEN, Jian Jeffrey ,  SIEGMUND, Aaron C. ,  AMEGADZIE, Albert ,  TAMAYO, Nuria A. ,  BOOKER, Shon ,  GOODMAN, Clifford ,  WALTON, Mary ,  NISHIMURA, Nobuko ,  SHIN, Youngsook ,  LOW, Jonathan D. ,  CEE, Victor J. ,  REED, Anthony B. ,  WANG, Hui-Ling ,  LANMAN, Brian Alan

IPC: C07D403/04 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  A61P35/00 ,  A61K31/519

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：WO2019051291A1

公开(公告)日：2019-03-14

申请号：PCT/US2018/050044

申请日：2018-09-07

Applicant: AMGEN INC.

Inventor： LANMAN, Brian Alan ,  BOOKER, Shon ,  GOODMAN, Clifford ,  REED, Anthony B. ,  LOW, Jonathan D. ,  WANG, Hui-Ling ,  CHEN, Ning ,  MINATTI, Ana Elena ,  WURZ, Ryan ,  CEE, Victor J.

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/519

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.