公开(公告)号：WO2015017710A1

公开(公告)日：2015-02-05

申请号：PCT/US2014/049254

申请日：2014-07-31

Applicant: AMGEN INC.

Inventor： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie, Z. ,  HAMBURGER, Agnes, Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  MOCK, Marissa ,  WALKER, Kenneth

IPC: C07K14/495 ,  C12N15/62

CPC classification number: C07K14/475 ,  C07K2319/30

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供了包含GDF15的构建体及其突变体。 在各种实施方案中，包含GDF15及其突变体的构建体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，葡萄糖水平升高，胰​​岛素水平升高和糖尿病肾病。

公开(公告)号：WO2013113008A1

公开(公告)日：2013-08-01

申请号：PCT/US2013/023465

申请日：2013-01-28

Applicant: AMGEN INC.

Inventor： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie Zeqi ,  HAMBURGER, Agnes Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  WALKER, Kenneth, W. ,  LEMON, Bryan

IPC: C12P21/08 ,  A61K39/00

CPC classification number: C07K14/475 ,  A61K39/0005 ,  A61K2039/6056 ,  C07K2319/30

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供GDF15多肽，包含GDF15的构建体及其突变体。 在各种实施方案中，GDF15多肽，包含GDF15的构建体及其突变体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。

公开(公告)号：WO2009070243A3

公开(公告)日：2009-06-04

申请号：PCT/US2008/012987

申请日：2008-11-21

Applicant: AMGEN INC.

Inventor： QIAN, Xueming ,  GRAHAM, Kevin ,  SHIMAMOTO, Grant ,  TIPTON, Barbara S. ,  TSAI, Mei-Mei ,  WINTERS, Aaron George ,  ZHANG, Li

IPC: C07K16/18 ,  A61K39/395

Abstract: The present invention relates to binding agents for WISE such as antibodies, and includes for their manufacture and use.