公开(公告)号：WO2013113008A1

公开(公告)日：2013-08-01

申请号：PCT/US2013/023465

申请日：2013-01-28

Applicant: AMGEN INC.

Inventor： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie Zeqi ,  HAMBURGER, Agnes Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  WALKER, Kenneth, W. ,  LEMON, Bryan

IPC: C12P21/08 ,  A61K39/00

CPC classification number: C07K14/475 ,  A61K39/0005 ,  A61K2039/6056 ,  C07K2319/30

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供GDF15多肽，包含GDF15的构建体及其突变体。 在各种实施方案中，GDF15多肽，包含GDF15的构建体及其突变体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。

公开(公告)号：WO2015017710A1

公开(公告)日：2015-02-05

申请号：PCT/US2014/049254

申请日：2014-07-31

Applicant: AMGEN INC.

Inventor： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie, Z. ,  HAMBURGER, Agnes, Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  MOCK, Marissa ,  WALKER, Kenneth

IPC: C07K14/495 ,  C12N15/62

CPC classification number: C07K14/475 ,  C07K2319/30

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供了包含GDF15的构建体及其突变体。 在各种实施方案中，包含GDF15及其突变体的构建体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，葡萄糖水平升高，胰​​岛素水平升高和糖尿病肾病。

公开(公告)号：WO2007124461A2

公开(公告)日：2007-11-01

申请号：PCT/US2007/067150

申请日：2007-04-20

Applicant: AMGEN INC. ,  GEGG, Colin, Victor, Jr., ,  MIRANDA, Leslie, Phillip ,  WINTERS, Katherine, Ann ,  VENIANT-ELLISON, Murielle

Inventor： GEGG, Colin, Victor, Jr., ,  MIRANDA, Leslie, Phillip ,  WINTERS, Katherine, Ann ,  VENIANT-ELLISON, Murielle

IPC: C07K14/60

CPC classification number: C07K14/605 ,  A61K38/00

Abstract: GLP-1 compounds comprising GLP-1 analogs and methods of using the GLP-1 compounds for treating metabolic disorders, enhancing insulin expression, and promoting insulin secretion in a patient are provided.

Abstract translation: 提供了包含GLP-1类似物的GLP-1化合物和使用GLP-1化合物治疗代谢紊乱，增强胰岛素表达和促进患者胰岛素分泌的方法。

公开(公告)号：WO2004031350A2

公开(公告)日：2004-04-15

申请号：PCT/US2003/030352

申请日：2003-09-25

Applicant: AMGEN, INC. ,  ISIS PHARMACEUTICALS, INC. ,  DOBIE, Kenneth, W. ,  BHANOT, Sanjay ,  VENIANT-ELLISON, Murielle ,  LINDBERG, Richard, A. ,  SHUTTER, John, R.

Inventor： DOBIE, Kenneth, W. ,  BHANOT, Sanjay ,  VENIANT-ELLISON, Murielle ,  LINDBERG, Richard, A. ,  SHUTTER, John, R.

IPC: C12N

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleid acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.

Abstract translation: 提供反义化合物，组合物和方法用于调节叉头盒O1A的表达。 组合物包含靶向编码叉头盒O1A的核酸的反义化合物，特异性反义寡核苷酸。 提供使用这些化合物调制叉头盒O1A表达和用于治疗与叉头盒O1A的表达相关的疾病的方法，特别是用于治疗糖尿病的方法。

公开(公告)号：WO2017059371A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/055017

申请日：2016-09-30

Applicant: AMGEN INC.

Inventor： XU, Jing ,  STANISLAUS, Shanaka ,  CHEN, Mei-Hsiu M. ,  HALE, Clarence H. ,  VENIANT-ELLISON, Murielle

IPC: A61K38/18 ,  A61P1/16

CPC classification number: A61K38/1825

Abstract: The invention relates method of treating a patient in need thereof with a long acting agonist to the FGF21 signaling pathway. In a particular embodiment, the invention relates to the use of molecules that stimulate the FGF21 signaling pathway, such as long acting FGF21 polypeptides or agonist antibodies, to treat disorders or diseases associated with excess bile acid. The invention further relates to pharmaceutical formulations and dosing of long acting agonists of the FGF21 signaling pathway suitable for treating bile acid related disorders.

Abstract translation: 本发明涉及将有需要的患者用长效激动剂治疗FGF21信号通路的方法。 在一个具体实施方案中，本发明涉及刺激FGF21信号传导途径的分子（例如长效FGF21多肽或激动剂抗体）用于治疗与过量胆汁酸相关的疾病或疾病的用途。 本发明还涉及适用于治疗胆汁酸相关疾病的FGF21信号传导途径的长效激动剂的药物制剂和给药。

公开(公告)号：WO2016061551A1

公开(公告)日：2016-04-21

申请号：PCT/US2015/056091

申请日：2015-10-16

Applicant: AMGEN INC.

Inventor： LU, Shu-Chen ,  VENIANT-ELLISON, Murielle ,  XU, Jing ,  SALIMI-MOOSAVI, Hossein ,  OLINER, Jonathan D.

IPC: C07K16/22 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/76

Abstract: The present disclosure provides methods of treating ocular disorders using anti-angiogenic antibodies and pharmaceutical formulations.

Abstract translation: 本公开提供了使用抗血管生成抗体和药物制剂治疗眼部疾病的方法。

公开(公告)号：WO2007124463A1

公开(公告)日：2007-11-01

申请号：PCT/US2007/067152

申请日：2007-04-20

Applicant: AMGEN INC. ,  SHEN, Weyan ,  GRAHAM, Kevin ,  WINTERS, Katherine, Ann ,  VENIANT-ELLISON, Murielle ,  BOONE, Thomas, Charles

Inventor： SHEN, Weyan ,  GRAHAM, Kevin ,  WINTERS, Katherine, Ann ,  VENIANT-ELLISON, Murielle ,  BOONE, Thomas, Charles

IPC: A61K39/395 ,  C07K14/605 ,  C07K16/26

CPC classification number: C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

Abstract: Compositions comprising antibodies that bind glucagon linked to GLP-I compounds are provided, as well as methods of using the compositions for treating, for example, metabolic disorders, enhancing insulin expression, and promoting insulin secretion in a subject.

Abstract translation: 提供了包含与GLP-1化合物连接的胰高血糖素的抗体的组合物，以及使用该组合物治疗例如代谢紊乱，增强胰岛素表达和促进受试者胰岛素分泌的方法。

公开(公告)号：WO2006116660A3

公开(公告)日：2006-11-02

申请号：PCT/US2006/016174

申请日：2006-04-27

Applicant: AMGEN INC. ,  GU, Wei ,  GRAHAM, Melissa, L. ,  VENIANT-ELLISON, Murielle

Inventor： GU, Wei ,  GRAHAM, Melissa, L. ,  VENIANT-ELLISON, Murielle

IPC: G01N33/68 ,  A61K39/395 ,  A61K48/00

Abstract: The invention provides methods of identifying modulators, for example, inhibitors, of a G-protein coupled receptor. The modulators can be used for the treatment or prevention of metabolic disorders such as dyslipidemia, metabolic syndrome and obesity. The invention also provides methods of treating or preventing metabolic disorders by administering modulators of G-protein coupled receptor function.