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公开(公告)号：WO2018064307A2
公开(公告)日：2018-04-05
申请号：PCT/US2017/053967
申请日：2017-09-28
Applicant: AMGEN INC.
Inventor： HUH, Joon , STEVENSON, Riki , BONDARENKO, Pavel , NICHOLS, Andrew , REN, Da , AGRAWAL, Neeraj Jagdish , SMITH, Richard
Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
Abstract translation: 本发明涉及制备粘度降低的抗原结合蛋白的方法。 该方法通过用高粘度可变结构域亚家族中的残基替换与低粘度亚家族相关的残基来进行。 该方法进一步包括用具有低粘度的残基取代Fc结构域中的残基并将带电荷的残基添加到Fc结构域的C端。 本发明还涉及通过该方法产生的抗原结合蛋白。
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公开(公告)号：WO2018064307A3
公开(公告)日：2018-04-05
申请号：PCT/US2017/053967
申请日：2017-09-28
Applicant: AMGEN INC.
Inventor： HUH, Joon , STEVENSON, Riki , BONDARENKO, Pavel , NICHOLS, Andrew , REN, Da , AGRAWAL, Neeraj Jagdish , SMITH, Richard
Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
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公开(公告)号：WO2018064307A4
公开(公告)日：2018-04-05
申请号：PCT/US2017/053967
申请日：2017-09-28
Applicant: AMGEN INC.
Inventor： HUH, Joon , STEVENSON, Riki , BONDARENKO, Pavel , NICHOLS, Andrew , REN, Da , AGRAWAL, Neeraj Jagdish , SMITH, Richard
Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
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