公开(公告)号：WO2022056455A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/050238

申请日：2021-09-14

Applicant: AMGEN INC.

Inventor： MCAULEY, Arnold ,  TREUHEIT, Michael, J. ,  CHRISTIAN, Twinkle, R. ,  JAGANNATHAN, Bharadwaj

IPC: A61K9/19 ,  A61K38/16 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  C07K14/00

Abstract: Disclosed herein are methods of preparing lyophilized formulations comprising a protein, such as an antibody or a bispecific antibody construct, that exhibits improved storage stability.

公开(公告)号：WO2006065861A2

公开(公告)日：2006-06-22

申请号：PCT/US2005/045169

申请日：2005-12-12

Applicant: AMGEN INC ,  TREUHEIT, Michael, J. ,  DHARMAVARAM, Vasumathi ,  PURTELL, Judith ,  ROY, Suzanne, E.

Inventor： TREUHEIT, Michael, J. ,  DHARMAVARAM, Vasumathi ,  PURTELL, Judith ,  ROY, Suzanne, E.

IPC: A61K38/18 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K9/19 ,  A61K38/1825 ,  A61K47/183 ,  A61K47/26 ,  C07K14/50

Abstract: The present invention provides long-term stable formulations of lyophilized keratinocyte growth factor and methods for making a lyophilized composition comprising keratinocyte growth factor.

Abstract translation: 本发明提供了冻干角化细胞生长因子的长期稳定制剂和制备包含角化细胞生长因子的冻干组合物的方法。