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公开(公告)号：WO2019133961A1
公开(公告)日：2019-07-04
申请号：PCT/US2018/068118
申请日：2018-12-31
发明人： RAUM, Tobias , ARVEDSON, Tara , BAILIS, Julie , DAHLHOFF, Christoph , ROSS, Sandra , CHEN, Irwin , BLÜMEL, Claudia , NAHRWOLD, Elisabeth , PENDZIALEK, Jochen , WAHI, Joachim
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/3092 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：WO2017021362A1
公开(公告)日：2017-02-09
申请号：PCT/EP2016/068319
申请日：2016-08-01
发明人： RAUM, Tobias , PENDZIALEK, Jochen , BLUEMEL, Claudia , BOTT, Franziska , DAHLHOFF, Christoph , HOFFMANN, Patrick , NAHRWOLD, Elisabeth
CPC分类号： C07K16/40 , C07K16/2809 , C07K16/2863 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present disclosure relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the disclosure provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the disclosure provides a process for the production of the antibody construct of the disclosure, a medical use of said antibody construct and a kit comprising said antibody construct.
摘要翻译： 本公开涉及双特异性抗体构建体，其包含结合靶细胞表面上的人FLT3的第一结合结构域和与T细胞表面上的人CD3结合的第二结合结构域。 此外，本公开提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体和用所述多核苷酸或载体转化或转染的宿主细胞。 此外，本公开提供了制备本公开的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。
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公开(公告)号：WO2014140368A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/055311
申请日：2014-03-17
发明人： KUFER, Peter , RAUM, Tobias , MUENZ, Markus , PENDZIALEK, Jochen , FIERS, Walter , SAELENS, Xavier , ROOSE, Kenny
CPC分类号： C07K16/468 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K16/1018 , C07K16/2809 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use / method of treatment relating to said antibody construct, and a kit comprising said antibody construct.
摘要翻译： 本发明涉及包含对流感病毒包膜蛋白M2（M2e）的细胞外部分特异的第一人结合结构域和CD3特异性的第二结构域的抗体构建体。 此外，本发明提供编码抗体构建体的核酸分子，包含所述核酸分子的载体和用所述核酸分子或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，包含所述抗体构建体的药物组合物，与所述抗体构建体有关的医疗用途/治疗方法，以及包含所述抗体构建体的试剂盒。
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公开(公告)号：WO2017021349A1
公开(公告)日：2017-02-09
申请号：PCT/EP2016/068285
申请日：2016-08-01
发明人： RAUM, Tobias , KUFER, Peter , PENDZIALEK, Jochen , BLUEMEL, Claudia , DAHLHOFF, Christoph , HOFFMANN, Patrick , LUTTERBUESE, Ralf , NAHRWOLD, Elisabeth
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a Tcell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
摘要翻译： 本发明涉及双特异性抗体构建体，其包含与靶细胞表面上的人类DLL3结合的第一结合结构域和与T细胞表面上的人CD3结合的第二结合结构域。 此外，本发明提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体和用所述多核苷酸或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。
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