公开(公告)号：WO2023086965A2

公开(公告)日：2023-05-19

申请号：PCT/US2022/079755

申请日：2022-11-11

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David A. ,  CHENG, David R. ,  YAN, Winston X.

IPC分类号： C12N9/22 ,  C12N15/113 ,  C12N15/10

摘要： The present invention relates to nucleases or nucleic acids encoding the nucleases, RNA guides or nucleic acids encoding the RNA guides, processes for characterizing the nucleases and/or RNA guides, compositions comprising the nucleases and/or RNA guides, and kits and/or methods for preparing and/or using the nucleases and/or RNA guides.

公开(公告)号：WO2020018142A1

公开(公告)日：2020-01-23

申请号：PCT/US2018/068007

申请日：2018-12-28

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： CHENG, David R. ,  SCOTT, David A. ,  YAN, Winston X.

IPC分类号： C12N15/113

摘要： The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR-Cas systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

公开(公告)号：WO2023086938A2

公开(公告)日：2023-05-19

申请号：PCT/US2022/079715

申请日：2022-11-11

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David A. ,  CHENG, David R. ,  YAN, Winston X.

IPC分类号： C12N9/22 ,  C12N15/11 ,  C12N15/90 ,  A61K38/46 ,  A61K31/7088

摘要： The present invention relates to nucleases or nucleic acids encoding the nucleases, RNA guides or nucleic acids encoding the RNA guides, processes for characterizing the nucleases and/or RNA guides, compositions comprising the nucleases and/or RNA guides, and kits and/or methods for preparing and/or using the nucleases and/or RNA guides.

公开(公告)号：WO2022159741A1

公开(公告)日：2022-07-28

申请号：PCT/US2022/013375

申请日：2022-01-21

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David A. ,  CHENG, David R. ,  YAN, Winston X. ,  DITOMMASO, Tia M.

IPC分类号： A61K38/46 ,  A61K48/00 ,  C07K19/00 ,  C12N15/113

摘要： The present invention relates to nucleases or nucleic acids encoding the nucleases, RNA guides or nucleic acids encoding the RNA guides, processes for characterizing the nucleases and/or RNA guides, compositions comprising the nucleases and/or RNA guides, and kits and/or methods for preparing and/or using the nucleases and/or RNA guides.

公开(公告)号：WO2019090173A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/059089

申请日：2018-11-02

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David A. ,  CHENG, David R. ,  YAN, Winston X.

IPC分类号： C12N9/22 ,  C12N15/10 ,  C12N15/90 ,  C12N15/113 ,  C07K14/195

摘要： The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of DNA, RNA, and protein substrates. Each system includes one or more protein components and one or more nucleic acid components that together target DNA, RNA, or protein substrates.

公开(公告)号：WO2019006471A2

公开(公告)日：2019-01-03

申请号：PCT/US2018/040649

申请日：2018-07-02

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： CHENG, David R. ,  SCOTT, David A. ,  YAN, Winston X. ,  CHONG, Shaorong

摘要： The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of a nucleic acid.

公开(公告)号：WO2023039534A2

公开(公告)日：2023-03-16

申请号：PCT/US2022/076216

申请日：2022-09-09

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： JAKIMO, Noah Michael ,  HUNNEWELL, Pratyusha ,  HILBERT, Brendan Jay ,  SCOTT, David A.

IPC分类号： C12N9/22 ,  C12N15/74

摘要： The present invention relates to compositions comprising a Cas12i polypeptide, a deaminase polypeptide, and an RNA guide, processes for characterizing the compositions, cells comprising the compositions, Cas12i fusion proteins, Cas12i complexes, and methods of using the compositions.

公开(公告)号：WO2021113522A1

公开(公告)日：2021-06-10

申请号：PCT/US2020/063125

申请日：2020-12-03

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David A. ,  YAN, Winston X. ,  CHENG, David R. ,  DITOMMASO, Tia M.

IPC分类号： C12N15/52 ,  C12N15/62 ,  C12N15/90 ,  C12N9/22

摘要： The present invention relates to genes coding for nucleases, processes for characterizing the nucleases, cells comprising the nucleases, and methods of using the nucleases.

公开(公告)号：WO2019090175A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/059091

申请日：2018-11-02

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David A. ,  CHENG, David R. ,  YAN, Winston X.

IPC分类号： C12N9/22 ,  C12N15/10 ,  C12N15/90 ,  C12N15/113

摘要： The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of DNA, RNA, and protein substrates. Each system includes one or more protein components and one or more nucleic acid components that together target DNA, RNA, or protein substrates.

公开(公告)号：WO2019090174A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/059090

申请日：2018-11-02

申请人： ARBOR BIOTECHNOLOGIES, INC.

发明人： SCOTT, David A. ,  CHENG, David R. ,  YAN, Winston X.

IPC分类号： C12N9/22 ,  C12N15/10 ,  C12N15/90 ,  C12N15/113 ,  C12N15/63 ,  C07K14/195

摘要： The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of DNA, RNA, and protein substrates. Each system includes one or more protein components and one or more nucleic acid components that together target DNA, RNA, or protein substrates.