公开(公告)号：WO2009126225A8

公开(公告)日：2010-01-28

申请号：PCT/US2009002096

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA ,  EWING CHARLES A ,  BRADSHAW JOHN THOMAS

IPC: B05B5/16 ,  B05B5/00 ,  F04B19/00

CPC classification number: G01N21/00 ,  B01L3/0234 ,  B01L2200/14 ,  B01L2200/148 ,  G01F25/0092

Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 描述了使用含有一种或多种染料的溶液改进液体递送评价的系统和相关方法，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。 该系统包括：能够测量多个波长的光吸收的光度仪; 使用其性能正在测试或校准的液体输送系统来分配的一种或多种样品溶液; 和任选地预先填充或由使用者填充的容器用稀释剂溶液。 样品溶液含有一种或多种染料，其选择使得可以区分感兴趣的体积或稀释范围的多种不同的可检测光吸收光谱特征，例如溶液的峰和/或谷和/或平台。 可以选择染料的浓度，使得使用溶液中的光谱特征来校准大体积输送装置，每单位通路长度具有低吸光度，而小体积输送装置用相同的样品溶液校准，但使用不同的光谱 特征具有每单位光程长的高吸光度。

公开(公告)号：WO2009126225A3

公开(公告)日：2009-12-17

申请号：PCT/US2009002096

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA ,  EWING CHARLES A ,  BRADSHAW JOHN THOMAS

IPC: B05B5/16 ,  B05B5/00 ,  F04B19/00

CPC classification number: G01N21/00 ,  B01L3/0234 ,  B01L2200/14 ,  B01L2200/148 ,  G01F25/0092

Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 描述了使用含有一种或多种染料的溶液改进液体递送评估的系统和相关方法，使得该溶液表现出多个不同的可检测光吸收光谱特征用于在扩展体积或稀释范围上校准或测试。 该系统包括：能够测量多个波长处的光吸收率的光度测量仪器; 使用其性能正在测试或校准的液体输送系统分配的一种或多种样品溶液; 以及可选地预先填充或由使用者填充稀释剂溶液的容器。 样品溶液含有一种或多种染料，所选择的染料可以针对感兴趣的体积或稀释范围区分溶液的多个不同的可检测光吸收光谱特征，例如峰和/或谷和/或平台。 可以选择染料的浓度，以便使用溶液中的光谱特征来校准大体积递送装置，其中每单位光程长度具有低吸光度，而小体积递送装置用相同的样品溶液校准，但使用不同的光谱 具有每单位光程长度的高吸光度。

公开(公告)号：WO2007081453A2

公开(公告)日：2007-07-19

申请号：PCT/US2006046272

申请日：2006-12-05

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA J ,  EWING CHARLES A

IPC: G01N21/00

CPC classification number: G01N1/38 ,  G01F22/00 ,  G01N21/314

Abstract: A method, apparatus and kit for precisely and accurately determining the volume of a liquid aliquot which can be used to calibrate a liquid delivery device. Two dye-containing solutions, a sample solution and a diluent solution, are prepared such that each solution contains a different dye, with the solutions having different absorbance values at a first wavelength and at a second wavelength. The absorbance value of a known volume of diluent solution is measured at both wavelengths. Either one aliquot of sample solution is added to the diluent solution and then absorbance measurements are made at both wavelengths, or multiple aliquots of sample solution are mixed serially into the diluent solution and then absorbance measurements are made at both wavelengths after each aliquot is added. The volume of any single aliquot is calculated by using a two-step formula which is based on the Beer-Lambert law.

Abstract translation: 用于精确和准确地确定可用于校准液体输送装置的液体等分量的体积的方法，设备和工具包。 制备两种含染料的溶液，样品溶液和稀释剂溶液，使得每种溶液含有不同的染料，溶液在第一波长和第二波长具有不同的吸光度值。 在两个波长处测量已知体积的稀释剂溶液的吸光度值。 将一份样品溶液加入到稀释溶液中，然后在两种波长下进行吸光度测量，或者将多份样品溶液连续混合到稀释溶液中，然后在添加每份等分试样后在两个波长处进行吸光度测量。 通过使用基于比尔 - 朗伯定律的两步公式计算任何单等分的体积。

公开(公告)号：WO2007126908A3

公开(公告)日：2008-08-28

申请号：PCT/US2007007706

申请日：2007-03-30

Applicant: ARTEL INC ,  CURTIS RICHARD H ,  BOHNSACK DAVID L ,  RODRIGUES GEORGE ,  BOILLAT MARC

Inventor： CURTIS RICHARD H ,  BOHNSACK DAVID L ,  RODRIGUES GEORGE ,  BOILLAT MARC

IPC: B01L3/02 ,  B67D7/30

CPC classification number: B01L3/0227 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0663 ,  G01N35/1016

Abstract: An air displacement liquid delivery system including a liquid delivery device, one or more sensors, a control unit, and a preprogrammable computing device, and a method for using the air displacement liquid delivery system. The one or more sensors are capable of obtaining information regarding conditions within and external to the liquid delivery device and sending this information to the control unit and/or the computing device. In turn, the control unit and/or computing device are capable of using this information to calculate one or more properties of gas contained within, and the air external to, the liquid delivery device, and one or more properties of a liquid that it is to be aspirated or dispensed by the liquid delivery device. The system may optimally control the performance of the liquid delivery device based upon any one or more of these calculated properties..

Abstract translation: 一种包括液体输送装置，一个或多个传感器，控制单元和可预编程计算装置的排气液体输送系统，以及使用所述排气液体输送系统的方法。 一个或多个传感器能够获得关于液体输送装置内部和外部的条件的信息，并将该信息发送到控制单元和/或计算装置。 反过来，控制单元和/或计算设备能够使用该信息来计算包含在液体输送装置内部和外部的空气中的气体的一种或多种性质，以及液体的一种或多种性质 被液体输送装置吸入或分配。 该系统可以基于这些计算的属性中的任何一个或多个来最佳地控制液体输送装置的性能。

公开(公告)号：WO2005074492A3

公开(公告)日：2006-03-23

申请号：PCT/US2005001769

申请日：2005-01-21

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H

IPC: G01J1/10 ,  G01J3/42 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/274 ,  G01N21/278 ,  G01N21/31 ,  G01N2021/054 ,  G01N2201/127 ,  G01N2201/1285 ,  G01N2201/1286

Abstract: An apparatus and related method for optical calibration of spectrophotometers is described. The apparatus is a calibration plate including one or more cuvettes filled with solutions of interest. The cuvettes are sealed to prevent evaporation. The cuvettes also possess a compressible component to allow for expansion of the solution and a bubble control apparatus to ensure that the compressible component does not intersect the beam path. A piece of neutral density glass is optionally included in the apparatus to track optical changes of the solutions over time.

Abstract translation: 描述了用于分光光度计的光学校准的装置和相关方法。 该装置是包括一个或多个充满感兴趣的溶液的比色杯的校准板。 试管被密封以防止蒸发。 试管还具有允许溶液膨胀的可压缩部件和气泡控制装置，以确保可压缩部件不与光束路径相交。 装置中可选地包括一片中性密度玻璃，以跟踪溶液随时间的光学变化。

公开(公告)号：WO2009126224A3

公开(公告)日：2011-07-14

申请号：PCT/US2009002089

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： MCNALLY CEARA J ,  BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  EWING CHARLES A ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  ROGERS ALEXIS L

IPC: G01N21/00

CPC classification number: G01F25/0084 ,  G01F22/00

Abstract: A system and related method for improved liquid delivery evaluation uses a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; a sample solution to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels with diluent solution. The sample solutions contain a dye, chosen so that multiple distinct detectable light absorbance spectral features can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device, and a small volume delivery device, are calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 用于改进液体递送评估的系统和相关方法使用含有一种或多种染料的溶液，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。 该系统包括：能够测量多个波长的光吸收的光度仪; 使用正在测试或校准其性能的液体输送系统分配的样品溶液; 和稀释液溶液。 样品溶液含有一种染料，其选择使得可以区分感兴趣的体积或稀释范围的多个不同的可检测光吸收光谱特征。 可以选择染料的浓度，使得用相同的样品溶液校准大体积输送装置和小体积输送装置，但是使用具有每单位光程长的高吸光度的不同光谱特征。

公开(公告)号：WO2007120465A2

公开(公告)日：2007-10-25

申请号：PCT/US2007008090

申请日：2007-04-02

Applicant: ARTEL INC ,  CURTIS RICHARD H ,  PILCHER KIRBY ,  BOHNSACK DAVID L ,  EWING CHARLES A ,  RODRIGUES GEORGE ,  BRADSHAW JOHN T ,  BOILLAT MARC

Inventor： CURTIS RICHARD H ,  PILCHER KIRBY ,  BOHNSACK DAVID L ,  EWING CHARLES A ,  RODRIGUES GEORGE ,  BRADSHAW JOHN T ,  BOILLAT MARC

IPC: B01L3/02 ,  G01N1/14

CPC classification number: B01L3/0237 ,  B01L3/021 ,  B01L3/0231 ,  B01L9/50 ,  B01L2300/023 ,  G01N35/1009 ,  G01N35/1011 ,  Y10T137/8225 ,  Y10T137/8242 ,  Y10T436/12 ,  Y10T436/2575

Abstract: A liquid aspirating and dispensing apparatus and method of using the apparatus. Among other elements, the apparatus includes a liquid handling device having one or more channel members, each of which has a removable liquid holding tip attached, and a signal transmitting device. A signal transmitted from the signal transmitting device may be used in a variety of ways to yield information regarding the performance of the apparatus. This information may be provided via direct detection of the signal by an operator of the apparatus. Alternatively, the signal may be detected by a programmable signal detecting device, interpreted by the apparatus, and then displayed in a form that is understandable to the operator. Furthermore, the liquid holding tip may be modified to enable different forms of signal transmission.

Abstract translation: 一种液体吸入和分配装置及其使用方法。 除了其它元件之外，该装置包括具有一个或多个通道构件的液体处理装置，每个通道构件具有附接的可移除的液体保持尖端和信号传输装置。 可以以各种方式使用从信号发送装置发送的信号来产生关于装置的性能的信息。 该信息可以通过设备的操作者直接检测信号来提供。 或者，可以由可编程信号检测装置检测信号，由装置解释，然后以对操作者可理解的形式显示。 此外，可以修改液体保持尖端以实现不同形式的信号传输。

公开(公告)号：WO2014012029A3

公开(公告)日：2014-03-06

申请号：PCT/US2013050332

申请日：2013-07-12

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H

IPC: G01N21/00 ,  G01N21/01 ,  G01N21/03

CPC classification number: G01F22/00 ,  G01F25/0084 ,  G01N21/00 ,  G01N21/59

Abstract: A system and related method for determining the volume of a sample solution delivered by a liquid delivery device. The system includes devices for adding and removing diluent, the sample solution under analysis and a mixture of the two in a cell having a substantially constant cross sectional area and a known horizontal optical path length. The system includes one or more spectrophotometers to measure horizontally and vertically absorbance associated with two distinct chromophores. A first chromophore of unknown concentration is in the diluent and a second chromophore of known concentration is in the sample solution. The method determines absorbance horizontally and vertically of the first chromophore prior to adding the sample solution and then determining absorbance of the first chromophore horizontally and vertically and the second chromophore horizontally after mixing the diluent and sample solution together.

Abstract translation: 一种用于确定由液体输送装置输送的样品溶液的体积的系统和相关方法。 该系统包括用于添加和去除稀释剂的装置，待分析的样品溶液和两个在具有基本上恒定的横截面积和已知水平光程长度的单元中的混合物。 该系统包括一个或多个分光光度计，用于测量与两个不同发色团相关的水平和垂直吸光度。 未知浓度的第一发色团在稀释剂中，已知浓度的第二发色团在样品溶液中。 该方法在添加样品溶液之前确定第一发色团的水平和垂直吸收，然后在将稀释剂和样品溶液混合在一起之后水平和垂直地测定第一发色团的吸光度，并且第二发色团水平地确定。

公开(公告)号：WO2008033521A2

公开(公告)日：2008-03-20

申请号：PCT/US2007020036

申请日：2007-09-14

Applicant: ARTEL INC

Inventor： BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  MCNALLY CEARA ,  ROGERS ALEX L

IPC: G01N21/75

CPC classification number: G01N21/31 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.

Abstract translation: 本发明提供了确定稀释溶液的影响的方法，其中稀释可以用于各种目的中的任何一种。 在一个实施例中，该方法能够实现与弯液面形状无关的精确的体积分配计算。 在另一个实施方案中，该方法能够准确地确定洗板效率。 在另一个实施方案中，该方法能够在多个稀释步骤中精确测定稀释比。 所描述的方法可以使用布置成执行步骤的一个或多个系统来执行。 本发明的试剂盒包括用于执行所述方法和任选的一种或多种适于进行光度测量的溶液的步骤的说明书。