公开(公告)号：WO2009126225A8

公开(公告)日：2010-01-28

申请号：PCT/US2009002096

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA ,  EWING CHARLES A ,  BRADSHAW JOHN THOMAS

IPC: B05B5/16 ,  B05B5/00 ,  F04B19/00

CPC classification number: G01N21/00 ,  B01L3/0234 ,  B01L2200/14 ,  B01L2200/148 ,  G01F25/0092

Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 描述了使用含有一种或多种染料的溶液改进液体递送评价的系统和相关方法，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。 该系统包括：能够测量多个波长的光吸收的光度仪; 使用其性能正在测试或校准的液体输送系统来分配的一种或多种样品溶液; 和任选地预先填充或由使用者填充的容器用稀释剂溶液。 样品溶液含有一种或多种染料，其选择使得可以区分感兴趣的体积或稀释范围的多种不同的可检测光吸收光谱特征，例如溶液的峰和/或谷和/或平台。 可以选择染料的浓度，使得使用溶液中的光谱特征来校准大体积输送装置，每单位通路长度具有低吸光度，而小体积输送装置用相同的样品溶液校准，但使用不同的光谱 特征具有每单位光程长的高吸光度。

公开(公告)号：WO2009126225A3

公开(公告)日：2009-12-17

申请号：PCT/US2009002096

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA ,  EWING CHARLES A ,  BRADSHAW JOHN THOMAS

IPC: B05B5/16 ,  B05B5/00 ,  F04B19/00

CPC classification number: G01N21/00 ,  B01L3/0234 ,  B01L2200/14 ,  B01L2200/148 ,  G01F25/0092

Abstract: A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 描述了使用含有一种或多种染料的溶液改进液体递送评估的系统和相关方法，使得该溶液表现出多个不同的可检测光吸收光谱特征用于在扩展体积或稀释范围上校准或测试。 该系统包括：能够测量多个波长处的光吸收率的光度测量仪器; 使用其性能正在测试或校准的液体输送系统分配的一种或多种样品溶液; 以及可选地预先填充或由使用者填充稀释剂溶液的容器。 样品溶液含有一种或多种染料，所选择的染料可以针对感兴趣的体积或稀释范围区分溶液的多个不同的可检测光吸收光谱特征，例如峰和/或谷和/或平台。 可以选择染料的浓度，以便使用溶液中的光谱特征来校准大体积递送装置，其中每单位光程长度具有低吸光度，而小体积递送装置用相同的样品溶液校准，但使用不同的光谱 具有每单位光程长度的高吸光度。

公开(公告)号：WO2007081453A2

公开(公告)日：2007-07-19

申请号：PCT/US2006046272

申请日：2006-12-05

Applicant: ARTEL INC

Inventor： CURTIS RICHARD H ,  MCNALLY CEARA J ,  EWING CHARLES A

IPC: G01N21/00

CPC classification number: G01N1/38 ,  G01F22/00 ,  G01N21/314

Abstract: A method, apparatus and kit for precisely and accurately determining the volume of a liquid aliquot which can be used to calibrate a liquid delivery device. Two dye-containing solutions, a sample solution and a diluent solution, are prepared such that each solution contains a different dye, with the solutions having different absorbance values at a first wavelength and at a second wavelength. The absorbance value of a known volume of diluent solution is measured at both wavelengths. Either one aliquot of sample solution is added to the diluent solution and then absorbance measurements are made at both wavelengths, or multiple aliquots of sample solution are mixed serially into the diluent solution and then absorbance measurements are made at both wavelengths after each aliquot is added. The volume of any single aliquot is calculated by using a two-step formula which is based on the Beer-Lambert law.

Abstract translation: 用于精确和准确地确定可用于校准液体输送装置的液体等分量的体积的方法，设备和工具包。 制备两种含染料的溶液，样品溶液和稀释剂溶液，使得每种溶液含有不同的染料，溶液在第一波长和第二波长具有不同的吸光度值。 在两个波长处测量已知体积的稀释剂溶液的吸光度值。 将一份样品溶液加入到稀释溶液中，然后在两种波长下进行吸光度测量，或者将多份样品溶液连续混合到稀释溶液中，然后在添加每份等分试样后在两个波长处进行吸光度测量。 通过使用基于比尔 - 朗伯定律的两步公式计算任何单等分的体积。

公开(公告)号：WO2009126224A3

公开(公告)日：2011-07-14

申请号：PCT/US2009002089

申请日：2009-04-03

Applicant: ARTEL INC

Inventor： MCNALLY CEARA J ,  BRADSHAW JOHN THOMAS ,  CURTIS RICHARD H ,  EWING CHARLES A ,  ALBERT KEITH J ,  KNAIDE TANYA R ,  ROGERS ALEXIS L

IPC: G01N21/00

CPC classification number: G01F25/0084 ,  G01F22/00

Abstract: A system and related method for improved liquid delivery evaluation uses a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; a sample solution to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels with diluent solution. The sample solutions contain a dye, chosen so that multiple distinct detectable light absorbance spectral features can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device, and a small volume delivery device, are calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.

Abstract translation: 用于改进液体递送评估的系统和相关方法使用含有一种或多种染料的溶液，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。 该系统包括：能够测量多个波长的光吸收的光度仪; 使用正在测试或校准其性能的液体输送系统分配的样品溶液; 和稀释液溶液。 样品溶液含有一种染料，其选择使得可以区分感兴趣的体积或稀释范围的多个不同的可检测光吸收光谱特征。 可以选择染料的浓度，使得用相同的样品溶液校准大体积输送装置和小体积输送装置，但是使用具有每单位光程长的高吸光度的不同光谱特征。

公开(公告)号：WO2007120465A2

公开(公告)日：2007-10-25

申请号：PCT/US2007008090

申请日：2007-04-02

Applicant: ARTEL INC ,  CURTIS RICHARD H ,  PILCHER KIRBY ,  BOHNSACK DAVID L ,  EWING CHARLES A ,  RODRIGUES GEORGE ,  BRADSHAW JOHN T ,  BOILLAT MARC

Inventor： CURTIS RICHARD H ,  PILCHER KIRBY ,  BOHNSACK DAVID L ,  EWING CHARLES A ,  RODRIGUES GEORGE ,  BRADSHAW JOHN T ,  BOILLAT MARC

IPC: B01L3/02 ,  G01N1/14

CPC classification number: B01L3/0237 ,  B01L3/021 ,  B01L3/0231 ,  B01L9/50 ,  B01L2300/023 ,  G01N35/1009 ,  G01N35/1011 ,  Y10T137/8225 ,  Y10T137/8242 ,  Y10T436/12 ,  Y10T436/2575

Abstract: A liquid aspirating and dispensing apparatus and method of using the apparatus. Among other elements, the apparatus includes a liquid handling device having one or more channel members, each of which has a removable liquid holding tip attached, and a signal transmitting device. A signal transmitted from the signal transmitting device may be used in a variety of ways to yield information regarding the performance of the apparatus. This information may be provided via direct detection of the signal by an operator of the apparatus. Alternatively, the signal may be detected by a programmable signal detecting device, interpreted by the apparatus, and then displayed in a form that is understandable to the operator. Furthermore, the liquid holding tip may be modified to enable different forms of signal transmission.

Abstract translation: 一种液体吸入和分配装置及其使用方法。 除了其它元件之外，该装置包括具有一个或多个通道构件的液体处理装置，每个通道构件具有附接的可移除的液体保持尖端和信号传输装置。 可以以各种方式使用从信号发送装置发送的信号来产生关于装置的性能的信息。 该信息可以通过设备的操作者直接检测信号来提供。 或者，可以由可编程信号检测装置检测信号，由装置解释，然后以对操作者可理解的形式显示。 此外，可以修改液体保持尖端以实现不同形式的信号传输。